HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 0.60 0.748

The method score is based on:

Property Details
Experiments 26095369, 19805520, 36906594, 18344987, 11927591, 26121674, 12485996, 34321665, 12419185
Identification Methods affinity chromatography technology, enzymatic study, pull down, coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000724 - double-strand break repair via homologous recombination
GO:0001673 - male germ cell nucleus
GO:0001741 - XY body
GO:0003677 - DNA binding
GO:0003684 - damaged DNA binding
and 7 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 143
Hs

1 1863
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024