HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

Property	Details
Experiments	26095369, 18406329, 14627815, 15613478, 20356835, 22184063, 20085707
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006302 - double-strand break repair GO:0006974 - DNA damage response GO:0019899 - enzyme binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 143 Hs			1 4128
+	Hs
		391652 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		470338 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		1300657 H2A1A_HUMAN (1-125): 8.26e-67: 200: 92.00		TRRAP_HUMAN (2754-4128): 0: 828: 15.88
+	Hs
		1296219 H2A1H_HUMAN (1-128): 2.85e-66: 198: 92.19		TRRAP_HUMAN (2754-4128): 0: 828: 15.88
+	Hs
		594872 H2A1D_HUMAN (1-129): 1.02e-65: 197: 90.70		TRRAP_HUMAN (2754-4128): 0: 828: 15.88
+	Mm
		650187 H2AX_MOUSE (1-143): 1.9e-73: 217: 97.20		ATM_MOUSE (3216-4128): 1.17e-165: 580: 18.84
+	Hs
		555448 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		ATM_HUMAN (3218-4128): 1.84e-158: 557: 19.42
+	Hs
		555452 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		ATR_HUMAN (3377-4128): 2.05e-122: 438: 19.28
+	Sc
		392119 H2A1_YEAST (16-142): 1.37e-53: 166: 75.59		TRA1_YEAST (2924-4127): 1.79e-115: 416: 14.57
+	Sc
		392423 H2A2_YEAST (16-124): 4.61e-53: 165: 82.57		TRA1_YEAST (2924-4127): 1.79e-115: 416: 14.57