HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: NONO (Q15233)
Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)
Gene: NONO

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	20000738
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 143 Hs			1 471
+	Hs
		516349 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89
+	Hs
		391681 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		PABP4_HUMAN (66-467): 1.55e-70: 237: 15.42
+	Hs
		470244 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89
+	Hs
		555478 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82
+	Sc
		376566 H2A2_YEAST (16-124): 4.61e-53: 165: 82.57		PABP_YEAST (30-384): 3.77e-37: 145: 16.50
+	Hs
		474005 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		PAB4L_HUMAN (139-369): 5.62e-18: 87.3: 14.09
+	Hs
		555437 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		ELAV2_HUMAN (150-210): 9.69e-14: 74.5: 25.81
+	Hs
		470365 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		ELAV2_HUMAN (150-210): 9.69e-14: 74.5: 25.81
+	Hs
		1216253 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		RBM4B_HUMAN (75-182): 7.1e-09: 59.3: 35.71
+	Hs
		1216259 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		RBM4_HUMAN (75-182): 7.64e-09: 59.3: 35.71
+	Hs
		1087093 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		RBM4B_HUMAN (75-182): 7.1e-09: 59.3: 35.71