HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	18274552
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	Histone~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 143 Hs			1 81
+	Hs
		555403 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		555404 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		474911 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		391643 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		470331 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		924034 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		924049 H2A3_HUMAN (1-129): 5.88e-66: 197: 91.47		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		260831 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		924397 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		924374 H2A1C_HUMAN (1-129): 5.04e-66: 198: 92.25		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		924387 H2A1H_HUMAN (1-128): 2.85e-66: 198: 92.19		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		391644 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		470332 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		924322 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		924334 H2A3_HUMAN (1-129): 5.88e-66: 197: 91.47		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		1079586 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		391718 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		470394 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Dm
		950447 H2A_DROME (17-124): 3.82e-60: 183: 90.74		R9PY16_DROME (1-68): 1.24e-24: 94.8: 51.47
+	Sc
		392251 H2A2_YEAST (16-124): 4.61e-53: 165: 82.57		RL40A_YEAST (1-76): 1.87e-32: 110: 55.26