HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: BARD1 (Q99728)
BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)
Gene: BARD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	12485996, 36906594
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Histone~zf-RING_6
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0016607 - nuclear speck GO:0046982 - protein heterodimerization activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 143 Hs			1 777
+	Hs
		391861 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Hs
		1087090 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Hs
		260986 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Hs
		555536 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		ANKH1_HUMAN (114-664): 2.01e-66: 242: 14.16
+	Hs
		391781 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		ANKH1_HUMAN (114-664): 2.01e-66: 242: 14.16
+	Hs
		470446 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		ANKH1_HUMAN (114-664): 2.01e-66: 242: 14.16
+	Hs
		555510 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		BCOR_HUMAN (152-543): 1.16e-44: 176: 23.93
+	Hs
		555597 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		260693 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		TNKS1_HUMAN (364-552): 9.86e-28: 122: 23.98
+	Hs
		1151369 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		391842 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		470504 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		1087083 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		1293188 H2AJ_HUMAN (1-125): 5.62e-65: 195: 93.60		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		260971 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		1087014 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		TNI3K_HUMAN (452-551): 1.71e-15: 82.9: 21.64
+	Hs
		1237344 H2A1H_HUMAN (1-128): 2.85e-66: 198: 92.19		ANR31_HUMAN (423-543): 1.48e-11: 70.5: 38.02