Protein: H2L2C8
Alpha-actinin, sarcomeric

Gene: H2L2C8, atn-1
Organism: Caenorhabditis elegans
Interactions: 111
UniProt ID: H2L2C8

Gene Ontology (top 5):
GO:0005509 - calcium ion binding
GO:0005865 - striated muscle thin filament
GO:0005886 - plasma membrane
GO:0030018 - Z disc
GO:0030036 - actin cytoskeleton organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

113218

G5EFG1
PDZ and LIM domain protein Zasp

3

20

High-throughput

0.825

High

116154

H2L2C8
Alpha-actinin, sarcomeric

2

15

High-throughput

0.754

High

116239

JAC1
Juxtamembrane domain-associated catenin

1

14

High-throughput

0.665

High

116175

SEM5
Sex muscle abnormal protein 5

3

17

High-throughput

0.639

High

109080

G4S034
Spectrin alpha chain

1

19

Small-scale

0.621

High

116162

PSA6
Proteasome subunit alpha type-6

4

4

High-throughput

0.616

High

116180

LIN36
Protein lin-36

3

15

High-throughput

0.583

High

116186

SUMO
Small ubiquitin-related modifier

3

8

High-throughput

0.583

High

116215

PSB3
Proteasome subunit beta type-3

3

5

High-throughput

0.583

High

116216

Q23482
Uncharacterized protein

3

1

High-throughput

0.583

High

115867

H2L0C1
Fibronectin type-III domain-containing protein

1

12

High-throughput

0.555

High

116163

O17666
Calponin-homology

1

1

High-throughput

0.555

High

110752

G5ECD7
cGMP-dependent protein kinase interacting domain-containing protein

2

20

High-throughput

0.533

High

116167

PQN59
Prion-like

2

2

High-throughput

0.533

High

116172

PSDE
26S proteasome non-ATPase regulatory subunit 14

2

6

High-throughput

0.533

High

116237

Q9TZA6
BTB domain-containing protein

2

17

High-throughput

0.533

High

116242

PBS5
Proteasome subunit pbs-5

2

2

High-throughput

0.533

High

116188

HMP1
Alpha-catenin-like protein hmp-1

1

13

High-throughput

0.515

High

116196

Q17549
MAGUK p55 subfamily member 5

1

13

High-throughput

0.515

High

112204

G5EE02
TRP homlogous cation channel protein

1

7

High-throughput

0.481

High

116161

O17084
Tandem-repeating region of mucin epiglycanin-like domain-containing protein

1

7

High-throughput

0.481

High

116164

O45313
EF-hand domain-containing protein

1

1

High-throughput

0.481

High

116165

WARTS
Serine/threonine-protein kinase WARTS homolog

1

4

Small-scale

0.481

High

116168

PRY1
Axin-like protein pry-1

1

1

High-throughput

0.481

High

116174

VINC
Vinculin

1

6

Small-scale

0.481

High

116177

PAC1
GTPase-activating protein pac-1

1

5

High-throughput

0.481

High

116185

LIN2
Protein lin-2

1

12

High-throughput

0.481

High

116202

BAR1
Beta-catenin/armadillo-related protein 1

1

8

High-throughput

0.481

High

116208

Q21529
Potassium channel domain-containing protein

1

1

High-throughput

0.481

High

116210

TPM1
Tropomyosin isoforms a/b/d/f

1

3

High-throughput

0.481

High

116246

DTN1
Dystrobrevin-1

1

4

High-throughput

0.481

High

116221

Q86GU1
SHSP domain-containing protein

1

11

Small-scale

0.445

High

61786

A3QM99
Dof-type domain-containing protein

1

1

High-throughput

0.439

High

92478

D3YT29
PDZ domain-containing protein

1

17

High-throughput

0.439

High

96555

E9P8A8
Rab GDP dissociation inhibitor

1

1

High-throughput

0.439

High

109053

CDC26
Anaphase-promoting complex subunit CDC26

1

1

High-throughput

0.439

High

110950

G5ECL3
Pre-RNA processing 21

1

8

High-throughput

0.439

High

111090

G5ECR7
RNA polymerase II transcription factor SIII p18 subunit

1

1

High-throughput

0.439

High

111304

G5ED07
Protein disulfide-isomerase

1

3

High-throughput

0.439

High

113037

G5EF90
DNA-binding protein

1

1

High-throughput

0.439

High

115324

H2KZ17
DiSHevelled related

1

13

High-throughput

0.439

High

115874

H2L0C6
Cep57 centrosome microtubule-binding domain-containing protein

1

1

High-throughput

0.439

High

116155

CSN2
COP9 signalosome complex subunit 2

1

1

High-throughput

0.439

High

116156

O01585
Rho-GAP domain-containing protein

1

4

High-throughput

0.439

High

116157

O01661
Guanylate kinase/L-type calcium channel beta subunit domain-containing protein

1

9

High-throughput

0.439

High

116158

RL7
Large ribosomal subunit protein uL30

1

1

High-throughput

0.439

High

116159

FIGL1
Fidgetin-like protein 1

1

10

High-throughput

0.439

High

116160

O16500
Activated in Blocked Unfolded protein response

1

2

High-throughput

0.439

High

116166

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

4

High-throughput

0.439

High

116169

O62332
Importin N-terminal domain-containing protein

1

1

High-throughput

0.439

High

116170

O76258
Tumor susceptibility gene 101 protein

1

5

High-throughput

0.439

High

116171

O76406
Kinetochore NuLl

1

1

High-throughput

0.439

High

116173

O76642
MATH domain-containing protein

1

1

High-throughput

0.439

High

116176

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

1

High-throughput

0.439

High

116178

COL90
Putative cuticle collagen 90

1

4

High-throughput

0.439

High

116179

ESS2
Splicing factor ESS-2

1

1

High-throughput

0.439

High

116181

YMX1
Uncharacterized protein K06H7.1

1

1

High-throughput

0.439

High

116182

MPK1
Mitogen-activated protein kinase mpk-1

1

7

High-throughput

0.439

High

116183

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.439

High

116184

GBG
Guanine nucleotide-binding protein subunit gamma

1

1

High-throughput

0.439

High

116187

P90823
7TM GPCR serpentine receptor class x

1

1

High-throughput

0.439

High

116189

EGL26
Egg-laying defective protein 26

1

1

High-throughput

0.439

High

116190

P91175
Pre-mRNA-splicing factor SYF1

1

1

High-throughput

0.439

High

116191

P91457
RanBP2-type domain-containing protein

1

2

High-throughput

0.439

High

116192

P91563
BTB domain-containing protein

1

20

High-throughput

0.439

High

116193

YP69
Uncharacterized protein B0495.9

1

1

High-throughput

0.439

High

116194

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.439

High

116195

PHA4
Defective pharyngeal development protein 4

1

1

High-throughput

0.439

High

116197

Q17746
ZZ-type domain-containing protein

1

2

High-throughput

0.439

High

116198

ELP4
Elongator complex protein 4

1

1

High-throughput

0.439

High

116199

Q18241
Helicase ARIP4

1

4

High-throughput

0.439

High

116200

Q18547
Replication factor C subunit 3

1

1

High-throughput

0.439

High

116201

Q18750
PEHE domain-containing protein

1

1

High-throughput

0.439

High

116203

Q19455
Ovule protein

1

1

High-throughput

0.439

High

116204

Q19465
Neuropeptide-Like Protein

1

1

High-throughput

0.439

High

116205

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.439

High

116206

Q20770
DUF19 domain-containing protein

1

1

High-throughput

0.439

High

116207

Q21015
EGF-like domain-containing protein

1

1

High-throughput

0.439

High

116209

Q22559
PDZ domain-containing protein

1

2

High-throughput

0.439

High

116211

Q22966
C-type lectin domain-containing protein

1

11

High-throughput

0.439

High

116212

UNC51
Serine/threonine-protein kinase unc-51

1

4

High-throughput

0.439

High

116213

TTC8
Tetratricopeptide repeat protein 8

1

5

High-throughput

0.439

High

116214

UNC83
Nuclear migration protein unc-83

1

1

Small-scale

0.439

High

116217

Q23546
non-specific serine/threonine protein kinase

1

2

High-throughput

0.439

High

116218

VATF
Probable V-type proton ATPase subunit F

1

1

High-throughput

0.439

High

116219

Q6AW08
Conserved oligomeric Golgi complex subunit 3

1

1

High-throughput

0.439

High

116220

Q7JNG1
Oligomycin sensitivity conferral protein

1

4

High-throughput

0.439

High

116222

Q8MXR2
RRM domain-containing protein

1

8

High-throughput

0.439

High

116223

RGS7
Regulator of G-protein signaling rgs-7

1

8

High-throughput

0.439

High

116224

MBK1
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1

1

9

High-throughput

0.439

High

116225

Q93696
glutathione transferase

1

1

High-throughput

0.439

High

116226

Q94241
Vesicle-trafficking protein SEC22b

1

3

High-throughput

0.439

High

116227

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.439

High

116228

PAT12
Protein pat-12

1

4

High-throughput

0.439

High

116229

DCLK
Serine/threonine-protein kinase zyg-8

1

18

High-throughput

0.439

High

116230

GPR1
G-protein regulator 1

1

1

High-throughput

0.439

High

116231

Q95Y13
Nucleoporin Nup133/Nup155-like N-terminal domain-containing protein

1

1

High-throughput

0.439

High

116232

Q9GYG1
C2H2-type domain-containing protein

1

1

High-throughput

0.439

High

116233

Q9GYR3
Neuropeptide-Like Protein

1

1

High-throughput

0.439

High

116234

Q9N3F4
RNA helicase

1

2

High-throughput

0.439

High

116235

Q9N499
CC domain-containing protein

1

1

High-throughput

0.439

High

116236

Q9N580
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

1

High-throughput

0.439

High

116238

Q9U304
RRM domain-containing protein

1

7

High-throughput

0.439

High

116240

Q9U3B9
Nucleoporin Nup54 alpha-helical domain-containing protein

1

5

High-throughput

0.439

High

116241

MBK2
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2

1

9

High-throughput

0.439

High

116243

Q9XVF6
CAlcium channel Localization Factor

1

1

High-throughput

0.439

High

116244

Q9XVW8
ZM domain-containing protein

1

1

High-throughput

0.439

High

116245

Q9XWK3
Nucleoporin p58/p45

1

4

High-throughput

0.439

High

73501

TBPL1
TATA box-binding protein-like 1

1

0

High-throughput

0.251

Low

115894

H2L0E0
SET domain-containing protein

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025