HitPredict

Interactor 1: ITB4 (P16144)
Integrin beta-4 (GP150) (CD antigen CD104)
Gene: ITGB4

Interactor 2: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15225631
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~fn3
Common GO terms	GO:0001664 - G protein-coupled receptor binding GO:0005730 - nucleolus GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1822 Hs			1 2647
+	Hs
		403783 ITB1_HUMAN (5-719): 0: 620: 34.57		FLNA_HUMAN (1-2647): 0: 2776: 100.00
+	Hs
		396566 ITB3_HUMAN (2-704): 0: 600: 34.02		FLNA_HUMAN (1-2647): 0: 2776: 100.00
+	Hs
		261181 ITB1_HUMAN (5-719): 0: 620: 34.57		FLNB_HUMAN (28-2647): 0: 2710: 69.63
+	Hs
		261179 ITB3_HUMAN (2-704): 0: 600: 34.02		FLNB_HUMAN (28-2647): 0: 2710: 69.63
+	Hs
		234453 DSCAM_HUMAN (739-1785): 2.9e-42: 172: 11.12		FLNB_HUMAN (28-2647): 0: 2710: 69.63
+	Mm
		447108 ITB1_MOUSE (541-823): 1.44e-12: 75.2: 13.29		FLNA_MOUSE (1-2647): 0: 2784: 97.32
+	Hs
		577567 ITB6_HUMAN (574-790): 3.15e-11: 70.5: 8.04		FLNA_HUMAN (1-2647): 0: 2776: 100.00
+	Hs
		597965 ITB7_HUMAN (573-789): 2.11e-10: 67.8: 9.13		FLNA_HUMAN (1-2647): 0: 2776: 100.00
+	Hs
		598253 TITIN_HUMAN (1016-1220): 3.3e-10: 67.8: 8.17		FLNA_HUMAN (1-2647): 0: 2776: 100.00
+	Hs
		261196 ITB6_HUMAN (574-790): 3.15e-11: 70.5: 8.04		FLNB_HUMAN (28-2647): 0: 2710: 69.63
+	Hs
		403752 ITB1_HUMAN (5-719): 0: 620: 34.57		ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53
+	Rn
		88558 ITB1_RAT (8-653): 0: 617: 36.03		D3ZCV0_RAT (27-459): 1.28e-118: 401: 24.50
+	Hs
		234502 DSCAM_HUMAN (739-1785): 2.9e-42: 172: 11.12		SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62
+	Hs
		234468 DSCAM_HUMAN (739-1785): 2.9e-42: 172: 11.12		ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53
+	Hs
		211436 DSCAM_HUMAN (739-1785): 2.9e-42: 172: 11.12		ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01
+	Mm
		472767 PTPRQ_MOUSE (1472-1821): 1.08e-32: 141: 15.23		ACTN1_MOUSE (20-459): 2.62e-118: 400: 24.12
+	Hs
		725681 TITIN_HUMAN (1016-1220): 3.3e-10: 67.8: 8.17		ACTN2_HUMAN (6-459): 1.76e-121: 410: 23.62
+	Hs
		521586 TITIN_HUMAN (1016-1220): 3.3e-10: 67.8: 8.17		ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53
+	Mm
		447075 ITB1_MOUSE (541-823): 1.44e-12: 75.2: 13.29		ACTN4_MOUSE (23-382): 3.46e-112: 383: 26.47
+	Hs
		211629 TITIN_HUMAN (1016-1220): 3.3e-10: 67.8: 8.17		ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01