HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: STF1 (Q13285)
Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP)
Gene: NR5A1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	17474147, unassigned3713
Identification Methods	peptide array, phage display
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 461
+	Hs
		209047 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		STF1_HUMAN (1-461): 1.69e-126: 376: 100.00
+	Hs
		655352 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		STF1_HUMAN (1-461): 1.69e-126: 376: 100.00
+	Hs
		412175 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		STF1_HUMAN (1-461): 1.69e-126: 376: 100.00
+	Hs
		1030589 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		STF1_HUMAN (1-461): 1.69e-126: 376: 100.00
+	Hs
		522959 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		STF1_HUMAN (1-461): 1.69e-126: 376: 100.00
+	Hs
		924542 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		STF1_HUMAN (1-461): 1.69e-126: 376: 100.00
+	Hs
		824471 ITSN2_HUMAN (7-85): 2.68e-12: 70.6: 24.05		NR2C2_HUMAN (11-457): 1.94e-116: 355: 21.80
+	Hs
		298963 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		NR1H2_HUMAN (5-460): 1.91e-78: 253: 20.26
+	Hs
		509895 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		VDR_HUMAN (5-456): 1.73e-83: 265: 17.11
+	Hs
		265847 FGR_HUMAN (7-150): 8.06e-20: 92.9: 20.00		NR1I2_HUMAN (10-456): 7.86e-76: 245: 20.09
+	Hs
		522864 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		RORG_HUMAN (12-459): 1.57e-79: 257: 20.73
+	Hs
		587120 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		RXRA_HUMAN (12-143): 5.48e-47: 170: 38.41
+	Hs
		320200 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		ERR2_HUMAN (2-166): 2.54e-54: 189: 40.72
+	Hs
		369031 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		ESR1_HUMAN (13-154): 2.14e-39: 151: 34.90
+	Hs
		522762 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		RXRA_HUMAN (12-143): 5.48e-47: 170: 38.41
+	Hs
		129156 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		ESR1_HUMAN (13-154): 2.14e-39: 151: 34.90
+	Hs
		368894 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		ESR1_HUMAN (13-154): 2.14e-39: 151: 34.90
+	Hs
		370679 VAV3_HUMAN (1-58): 1.16e-12: 71.4: 24.59		ESR1_HUMAN (13-154): 2.14e-39: 151: 34.90
+	Hs
		370586 ITSN2_HUMAN (7-85): 2.68e-12: 70.6: 24.05		ESR1_HUMAN (13-154): 2.14e-39: 151: 34.90
+	Hs
		368834 YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27		ESR1_HUMAN (13-154): 2.14e-39: 151: 34.90