Interactor 1: BIP (P16474)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein homolog) (GRP-78) (Immunoglobulin heavy chain-binding protein homolog) (BiP)
Gene: KAR2

Interactor 2: IRE1 (P32361)
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]
Gene: IRE1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 0.60 0.736

The method score is based on:

Property Details
Experiments 20625545, 23387983, 11118306, 17276461, 28689662, 17923530, 21266252
Identification Methods anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0030968 - endoplasmic reticulum unfolded protein response
and 1 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 682
Sc

1 1115
+ Hs
+ Ce
+ Ce
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ Hs
+ Hs
+ Sc

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Last updated: 15 Jul 2024