Protein: CCNA2
Cyclin-A2 (Cyclin-A) (Cyclin A)

Gene: CCNA2
Organism: Homo sapiens
Interactions: 163
UniProt ID: P20248

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0001939 - female pronucleus
GO:0001940 - male pronucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

629061

CDK2
Cyclin-dependent kinase 2

52

20

Small-scale

0.996

High

629078

CDN1B
Cyclin-dependent kinase inhibitor 1B

17

15

Small-scale

0.987

High

443173

CDK1
Cyclin-dependent kinase 1

18

20

Small-scale

0.987

High

629075

CDN1A
Cyclin-dependent kinase inhibitor 1

15

15

Small-scale

0.983

High

629157

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

5

12

High-throughput

0.932

High

629082

CDN1C
Cyclin-dependent kinase inhibitor 1C

5

15

Small-scale

0.927

High

629085

CDK7
Cyclin-dependent kinase 7

5

20

Small-scale

0.924

High

629100

CDK3
Cyclin-dependent kinase 3

4

20

High-throughput

0.903

High

629102

CDK5
Cyclin-dependent kinase 5

4

20

High-throughput

0.903

High

623987

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

3

6

High-throughput

0.861

High

629098

CCNA1
Cyclin-A1

3

5

High-throughput

0.861

High

629180

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

20

High-throughput

0.811

High

629109

CDC20
Cell division cycle protein 20 homolog

20

20

Small-scale

0.767

High

629114

SKP2
S-phase kinase-associated protein 2

14

4

Small-scale

0.760

High

629174

FZR1
Fizzy-related protein homolog

11

20

Small-scale

0.757

High

549050

CDK4
Cyclin-dependent kinase 4

2

20

Small-scale

0.754

High

629163

CDT1
DNA replication factor Cdt1

7

2

Small-scale

0.751

High

629093

CKS1
Cyclin-dependent kinases regulatory subunit 1

8

20

Small-scale

0.749

High

629064

RBL1
Retinoblastoma-like protein 1

8

7

Small-scale

0.748

High

442584

RB
Retinoblastoma-associated protein

8

7

Small-scale

0.747

High

629105

H11
Histone H1.1

7

7

Small-scale

0.743

High

629116

ORC1
Origin recognition complex subunit 1

6

7

Small-scale

0.736

High

629107

RBL2
Retinoblastoma-like protein 2

6

7

Small-scale

0.732

High

629179

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

6

1

Small-scale

0.730

High

629104

E2F1
Transcription factor E2F1

5

9

Small-scale

0.720

High

550833

PCNA
Proliferating cell nuclear antigen

5

1

Small-scale

0.714

High

629071

CKS2
Cyclin-dependent kinases regulatory subunit 2

5

20

Small-scale

0.714

High

629108

EP300
Histone acetyltransferase p300

4

6

Small-scale

0.694

High

629119

CUL1
Cullin-1

4

3

Small-scale

0.694

High

629106

KPCT
Protein kinase C theta type

1

3

High-throughput

0.691

High

629120

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.691

High

629142

CCNQ
Cyclin-Q

1

4

High-throughput

0.691

High

629176

PHF8
Histone lysine demethylase PHF8

5

0

Small-scale

0.682

High

284278

GEMI
Geminin

4

0

High-throughput

0.670

High

629131

MDEAS
Mitotic deacetylase-associated SANT domain protein

4

0

High-throughput

0.670

High

629161

SCAPE
S phase cyclin A-associated protein in the endoplasmic reticulum

4

0

High-throughput

0.670

High

629162

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

4

0

High-throughput

0.670

High

464804

SP1
Transcription factor Sp1

3

2

Small-scale

0.667

High

629158

CDC6
Cell division control protein 6 homolog

3

7

Small-scale

0.667

High

247079

TBCD4
TBC1 domain family member 4

3

1

High-throughput

0.667

High

629097

SKP1
S-phase kinase-associated protein 1

3

3

Small-scale

0.667

High

629136

TICRR
Treslin

3

1

High-throughput

0.667

High

629149

CBP
CREB-binding protein

3

4

High-throughput

0.667

High

629069

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.665

High

629172

APC4
Anaphase-promoting complex subunit 4

3

2

Small-scale

0.640

High

629144

HELB
DNA helicase B

3

0

High-throughput

0.638

High

629074

BRCA1
Breast cancer type 1 susceptibility protein

3

1

Small-scale

0.635

High

629057

CCNA2
Cyclin-A2

1

3

Small-scale

0.618

High

629070

AKT2
RAC-beta serine/threonine-protein kinase

1

3

Small-scale

0.618

High

629086

CDK9
Cyclin-dependent kinase 9

1

20

High-throughput

0.618

High

629101

CDK6
Cyclin-dependent kinase 6

1

20

Small-scale

0.618

High

629124

CDK10
Cyclin-dependent kinase 10

1

20

High-throughput

0.618

High

629178

AKT3
RAC-gamma serine/threonine-protein kinase

1

3

Small-scale

0.618

High

629117

ORC2
Origin recognition complex subunit 2

2

3

Small-scale

0.611

High

629128

SMTL2
Smoothelin-like protein 2

3

1

High-throughput

0.604

High

595310

H15
Histone H1.5

2

7

Small-scale

0.602

High

629063

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

3

Small-scale

0.595

High

629164

PKHG2
Pleckstrin homology domain-containing family G member 2

2

0

High-throughput

0.585

High

629066

CDC27
Cell division cycle protein 27 homolog

2

8

Small-scale

0.584

High

186696

P73
Tumor protein p73

1

3

Small-scale

0.578

High

629076

FEN1
Flap endonuclease 1

1

6

Small-scale

0.578

High

629150

KAT2B
Histone acetyltransferase KAT2B

1

4

Small-scale

0.578

High

629155

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

1

Small-scale

0.578

High

629146

MIPT3
TRAF3-interacting protein 1

2

1

High-throughput

0.576

High

629129

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.575

High

487972

DPOLA
DNA polymerase alpha catalytic subunit

1

2

Small-scale

0.561

High

629072

CTNB1
Catenin beta-1

1

5

Small-scale

0.561

High

629138

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

4

Small-scale

0.561

High

629123

SLBP
Histone RNA hairpin-binding protein

2

0

Small-scale

0.559

High

629115

CENPR
Centromere protein R

1

0

Small-scale

0.549

High

276429

PDCD6
Programmed cell death protein 6

1

1

High-throughput

0.536

High

430983

LA
Lupus La protein

1

2

High-throughput

0.536

High

629087

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.536

High

629121

TFDP1
Transcription factor Dp-1

1

4

High-throughput

0.536

High

629122

TFDP2
Transcription factor Dp-2

1

4

High-throughput

0.536

High

629127

E2F4
Transcription factor E2F4

1

9

High-throughput

0.536

High

629135

CSN6
COP9 signalosome complex subunit 6

1

6

High-throughput

0.536

High

629147

US6NL
USP6 N-terminal-like protein

1

1

High-throughput

0.536

High

629148

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.536

High

629151

CSN5
COP9 signalosome complex subunit 5

1

6

High-throughput

0.536

High

629077

MAGAB
Melanoma-associated antigen 11

1

0

Small-scale

0.529

High

629080

TSC2
Tuberin

1

1

Small-scale

0.515

High

326132

REC8
Meiotic recombination protein REC8 homolog

1

0

High-throughput

0.513

High

355065

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

0

High-throughput

0.513

High

389958

ALBU
Albumin

1

0

High-throughput

0.513

High

629058

IL10
Interleukin-10

1

0

High-throughput

0.513

High

629081

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.513

High

629084

ASCL1
Achaete-scute homolog 1

1

0

High-throughput

0.513

High

629099

CYC
Cytochrome c

1

0

High-throughput

0.513

High

629125

TAF11
Transcription initiation factor TFIID subunit 11

1

0

High-throughput

0.513

High

629126

TAF7
Transcription initiation factor TFIID subunit 7

1

0

High-throughput

0.513

High

629140

P3H2
Prolyl 3-hydroxylase 2

1

0

High-throughput

0.513

High

629145

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

629152

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.513

High

629156

UIMC1
BRCA1-A complex subunit RAP80

1

0

High-throughput

0.513

High

629159

CITE1
Cbp/p300-interacting transactivator 1

1

0

High-throughput

0.513

High

629160

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

629168

CRIPT
Cysteine-rich PDZ-binding protein

1

0

High-throughput

0.513

High

629173

INTU
Protein inturned

1

0

High-throughput

0.513

High

222710

PRC1
Protein regulator of cytokinesis 1

1

2

Small-scale

0.501

High

251704

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

6

Small-scale

0.501

High

413174

P53
Cellular tumor antigen p53

1

3

Small-scale

0.501

High

629059

NFYA
Nuclear transcription factor Y subunit alpha

1

1

Small-scale

0.501

High

629065

ARI4A
AT-rich interactive domain-containing protein 4A

1

1

Small-scale

0.501

High

629088

BRCA2
Breast cancer type 2 susceptibility protein

1

2

Small-scale

0.501

High

629090

RD23A
UV excision repair protein RAD23 homolog A

1

3

Small-scale

0.501

High

629091

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

Small-scale

0.501

High

629111

CAF1A
Chromatin assembly factor 1 subunit A

1

1

Small-scale

0.501

High

629171

HERC5
E3 ISG15--protein ligase HERC5

1

2

Small-scale

0.501

High

629154

DTBP1
Dysbindin

1

0

High-throughput

0.486

High

213065

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

Small-scale

0.479

High

221235

DCX
Neuronal migration protein doublecortin

1

1

Small-scale

0.479

High

259431

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

289925

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.479

High

302370

RNF8
E3 ubiquitin-protein ligase RNF8

1

3

Small-scale

0.479

High

407388

K2C1
Keratin, type II cytoskeletal 1

1

1

Small-scale

0.479

High

557082

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

Small-scale

0.479

High

587894

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

618214

CADH2
Cadherin-2

1

3

Small-scale

0.479

High

629060

GATA2
Endothelial transcription factor GATA-2

1

1

Small-scale

0.479

High

629062

NFYB
Nuclear transcription factor Y subunit beta

1

1

Small-scale

0.479

High

629067

MPIP1
M-phase inducer phosphatase 1

1

8

High-throughput

0.479

High

629068

MPIP2
M-phase inducer phosphatase 2

1

8

Small-scale

0.479

High

629073

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

629092

PSA6
Proteasome subunit alpha type-6

1

2

Small-scale

0.479

High

629094

RS14
Small ribosomal subunit protein uS11

1

1

Small-scale

0.479

High

629095

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

629096

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

629113

TIF1B
Transcription intermediary factor 1-beta

1

4

Small-scale

0.479

High

629118

BIRC2
Baculoviral IAP repeat-containing protein 2

1

4

Small-scale

0.479

High

629133

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

2

Small-scale

0.479

High

629134

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

629165

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

4

Small-scale

0.479

High

629166

APC11
Anaphase-promoting complex subunit 11

1

2

Small-scale

0.479

High

629170

UBQL2
Ubiquilin-2

1

2

High-throughput

0.479

High

629175

TRI33
E3 ubiquitin-protein ligase TRIM33

1

4

Small-scale

0.479

High

629177

EXO1
Exonuclease 1

1

6

Small-scale

0.479

High

629103

FANCC
Fanconi anemia group C protein

1

0

Small-scale

0.460

High

629079

PA24A
Cytosolic phospholipase A2

1

0

Small-scale

0.458

High

629083

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

629110

NFIA
Nuclear factor 1 A-type

1

0

High-throughput

0.458

High

629130

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

629137

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

629167

DTL
Denticleless protein homolog

1

0

Small-scale

0.458

High

629169

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

Small-scale

0.458

High

629089

MAT1
CDK-activating kinase assembly factor MAT1

1

1

High-throughput

0.445

High

629141

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

Small-scale

0.438

High

629139

ZCH18
Zinc finger CCCH domain-containing protein 18

1

2

High-throughput

0.437

High

629143

FBXL6
F-box/LRR-repeat protein 6

1

4

Small-scale

0.437

High

600077

ZNF20
Zinc finger protein 20

1

0

High-throughput

0.426

High

95923

E7ERS3
Zinc finger CCCH-type containing 18

1

1

High-throughput

0.407

High

379072

IGKC
Immunoglobulin kappa constant

1

2

High-throughput

0.407

High

379213

IGHG1
Immunoglobulin heavy constant gamma 1

1

2

High-throughput

0.407

High

379336

IGHG2
Immunoglobulin heavy constant gamma 2

1

2

High-throughput

0.407

High

629112

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.391

High

485924

GIP
Gastric inhibitory polypeptide

2

0

High-throughput

0.328

High

629153

MTBP
Mdm2-binding protein

2

0

High-throughput

0.318

High

369310

A1AT
Alpha-1-antitrypsin

1

0

High-throughput

0.279

Low

389790

TTHY
Transthyretin

1

0

High-throughput

0.279

Low

390861

TRFE
Serotransferrin

1

0

High-throughput

0.279

Low

629132

TXD11
Thioredoxin domain-containing protein 11

1

0

High-throughput

0.279

Low

261932

RNH1
Ribonuclease H1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025