HitPredict

Interactor 1: NUMB (P16554)
Protein numb
Gene: NUMB

Interactor 2: AP2A (P91926)
AP-2 complex subunit alpha (Alpha-adaptin)
Gene: AP-2alpha

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.723

Property	Details
Experiments	22474327, 12194853, 16139215, 18854163, 23523246, unassigned4
Identification Methods	affinity chromatography technology, pull down, experimental interaction detection
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008104 - protein localization GO:0045807 - positive regulation of endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 556 Dm			1 940
+	Hs
		302120 NUMB_HUMAN (42-546): 5.71e-93: 299: 36.92		AP2A2_HUMAN (1-940): 0: 829: 69.18
+	Hs
		321513 NUMB_HUMAN (42-546): 5.71e-93: 299: 36.92		AP2A1_HUMAN (1-940): 0: 815: 65.48
+	Rn
		1109842 Q3MUI1_RAT (42-465): 2.78e-76: 254: 41.20		Q66HM2_RAT (1-940): 0: 835: 69.46
+	Rn
		577194 Q3MUI1_RAT (42-465): 2.78e-76: 254: 41.20		AP2A2_RAT (1-940): 0: 835: 69.57
+	Mm
		567529 ANS1B_MOUSE (14-272): 2.84e-54: 200: 18.28		AP2A2_MOUSE (1-940): 0: 837: 69.67
+	Hs
		302137 DAB2_HUMAN (35-546): 5.64e-54: 197: 11.81		AP2A2_HUMAN (1-940): 0: 829: 69.18
+	Hs
		321528 DAB2_HUMAN (35-546): 5.64e-54: 197: 11.81		AP2A1_HUMAN (1-940): 0: 815: 65.48
+	Hs
		321527 SHC2_HUMAN (57-367): 5.34e-53: 191: 15.00		AP2A1_HUMAN (1-940): 0: 815: 65.48
+	Dm
		561280 NUMB_DROME (1-556): 2.59e-136: 408: 100.00		Q7KVR8_DROME (4-705): 0: 592: 25.31
+	Ce
		60774 A5JYR4_CAEEL (28-454): 4.92e-61: 211: 14.51		Q22601_CAEEL (1-940): 0: 773: 65.29
+	Hs
		833572 NUMB_HUMAN (42-546): 5.71e-93: 299: 36.92		AP2B1_HUMAN (33-935): 0: 669: 16.31
+	Hs
		833587 NUMB_HUMAN (42-546): 5.71e-93: 299: 36.92		AP1B1_HUMAN (33-935): 0: 654: 15.41
+	Rn
		923852 Q3MUI1_RAT (42-465): 2.78e-76: 254: 41.20		AP2B1_RAT (33-935): 0: 669: 16.31
+	Hs
		926067 NUMBL_HUMAN (30-552): 2.94e-73: 246: 36.45		AP2B1_HUMAN (33-935): 0: 669: 16.31
+	Hs
		925962 ANS1A_HUMAN (6-268): 1.47e-57: 209: 18.15		AP2B1_HUMAN (33-935): 0: 669: 16.31
+	Hs
		925893 ARH_HUMAN (43-324): 1e-58: 199: 18.24		AP2B1_HUMAN (33-935): 0: 669: 16.31
+	Hs
		925851 DAB2_HUMAN (35-546): 5.64e-54: 197: 11.81		AP2B1_HUMAN (33-935): 0: 669: 16.31
+	Hs
		1014028 ARH_HUMAN (43-324): 1e-58: 199: 18.24		AP1B1_HUMAN (33-935): 0: 654: 15.41
+	Hs
		957123 SHC2_HUMAN (57-367): 5.34e-53: 191: 15.00		AP1B1_HUMAN (33-935): 0: 654: 15.41
+	Ce
		60777 A5JYR4_CAEEL (28-454): 4.92e-61: 211: 14.51		Q8WQB3_CAEEL (8-815): 0: 556: 24.97