HitPredict

Interactor 1: ZNF8 (P17098)
Zinc finger protein 8 (Zinc finger protein HF.18)
Gene: ZNF8

Interactor 2: SIR1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: SIRT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	33961781, 31403225
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 575 Hs			1 747
+	Hs
		1055967 ZN460_HUMAN (19-565): 8e-91: 291: 34.40		SIR1_HUMAN (1-747): 0: 1052: 100.00
+	Hs
		1289397 ZN514_HUMAN (303-535): 6.34e-28: 117: 36.02		SIR1_HUMAN (1-747): 0: 1052: 100.00
+	Hs
		970665 ZNF45_HUMAN (62-198): 1.28e-21: 100: 10.22		SIR1_HUMAN (1-747): 0: 1052: 100.00
+	Hs
		1254431 ZN675_HUMAN (68-205): 8.09e-16: 82.5: 15.94		SIR1_HUMAN (1-747): 0: 1052: 100.00
+	Hs
		1205169 Z354C_HUMAN (502-569): 9.6e-12: 69.5: 16.18		SIR1_HUMAN (1-747): 0: 1052: 100.00
+	Hs
		1282571 ZN566_HUMAN (212-307): 1.3e-11: 68.6: 33.33		SIR1_HUMAN (1-747): 0: 1052: 100.00