HitPredict

Interactor 1: INAR1 (P17181)
Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)
Gene: IFNAR1

Interactor 2: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	33961781, 9334213
Identification Methods	affinity chromatography technology, genetic interference, biochemical, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0060337 - type I interferon-mediated signaling pathway GO:0098586 - cellular response to virus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 557 Hs			1 1154
+	Mm
		69810 IL3B2_MOUSE (124-478): 5.88e-56: 204: 14.29		B1ASP2_MOUSE (1-1154): 0: 1021: 94.63
+	Hs
		616805 I10R1_HUMAN (22-225): 9.94e-41: 157: 18.06		JAK1_HUMAN (1-1154): 0: 1035: 100.00
+	Hs
		616825 I20RB_HUMAN (3-229): 6.07e-42: 154: 17.65		JAK1_HUMAN (1-1154): 0: 1035: 100.00
+	Mm
		645934 IL3B2_MOUSE (124-478): 5.88e-56: 204: 14.29		JAK2_MOUSE (33-1153): 0: 778: 41.54
+	Mm
		645936 IL3RB_MOUSE (130-478): 6.85e-48: 180: 13.43		JAK2_MOUSE (33-1153): 0: 778: 41.54
+	Hs
		238373 INGR2_HUMAN (28-245): 4.95e-37: 141: 20.34		JAK2_HUMAN (33-1153): 0: 799: 42.14
+	Mm
		1143570 Q63953_MOUSE (21-329): 7.08e-42: 155: 22.26		JAK2_MOUSE (33-1153): 0: 778: 41.54
+	Hs
		238344 INGR1_HUMAN (225-542): 2.4e-30: 126: 16.19		JAK2_HUMAN (33-1153): 0: 799: 42.14
+	Mm
		546500 INGR1_MOUSE (2-344): 2.88e-34: 137: 14.09		JAK2_MOUSE (33-1153): 0: 778: 41.54
+	Hs
		566003 INAR1_HUMAN (1-557): 1.37e-149: 442: 100.00		TYK2_HUMAN (867-1152): 1.57e-32: 139: 19.00
+	Hs
		297880 NFASC_HUMAN (5-424): 3.3e-60: 218: 15.90		ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72
+	Hs
		297881 NFASC_HUMAN (5-424): 3.3e-60: 218: 15.90		FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74
+	Hs
		507837 INAR1_HUMAN (1-557): 1.37e-149: 442: 100.00		FGFR1_HUMAN (566-873): 6e-15: 82: 24.18
+	Hs
		565996 INAR1_HUMAN (1-557): 1.37e-149: 442: 100.00		FGFR2_HUMAN (580-873): 9.52e-13: 74.7: 22.74
+	Dm
		53796 A1Z921_DROME (21-430): 6.11e-35: 142: 14.45		ABL_DROME (868-1154): 1.63e-94: 334: 32.99
+	Hs
		507878 L1CAM_HUMAN (6-535): 2.48e-43: 168: 10.35		FGFR1_HUMAN (566-873): 6e-15: 82: 24.18
+	Hs
		385283 NRCAM_HUMAN (6-488): 7.46e-44: 169: 13.60		NTRK1_HUMAN (578-853): 2.13e-14: 80.1: 25.17
+	Hs
		384360 L1CAM_HUMAN (6-535): 2.48e-43: 168: 10.35		NTRK1_HUMAN (578-853): 2.13e-14: 80.1: 25.17
+	Hs
		508069 I20RB_HUMAN (3-229): 6.07e-42: 154: 17.65		FGFR1_HUMAN (566-873): 6e-15: 82: 24.18
+	Hs
		507827 INGR1_HUMAN (225-542): 2.4e-30: 126: 16.19		FGFR1_HUMAN (566-873): 6e-15: 82: 24.18