HitPredict

Interactor 1: JUNB (P17275)
Transcription factor JunB (Transcription factor AP-1 subunit JunB)
Gene: JUNB

Interactor 2: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.724

Property	Details
Experiments	28514442, 12080089, 33961781, 25184681, 18259752
Identification Methods	affinity chromatography technology, two hybrid, pull down, coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 347 Hs			1 1863
+	Hs
		401546 JUN_HUMAN (1-347): 5.04e-56: 187: 43.89		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		568071 JUND_HUMAN (5-347): 4.93e-44: 156: 39.12		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		749397 CREB5_HUMAN (28-345): 3.25e-31: 124: 13.08		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		749535 NF2L2_HUMAN (8-330): 3.51e-27: 114: 14.71		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		556798 CREB1_HUMAN (64-323): 6.09e-26: 107: 14.04		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		579128 ATF1_HUMAN (149-322): 4.45e-26: 106: 17.94		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Mm
		404126 JUN_MOUSE (1-347): 8.87e-57: 189: 44.32		BRCA1_MOUSE (1-1858): 0: 1394: 55.69
+	Mm
		562974 ATF2_MOUSE (20-347): 5.18e-32: 126: 15.94		BRCA1_MOUSE (1-1858): 0: 1394: 55.69
+	Hs
		536790 CREB5_HUMAN (28-345): 3.25e-31: 124: 13.08		TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74
+	Hs
		556944 CREB1_HUMAN (64-323): 6.09e-26: 107: 14.04		TRI11_HUMAN (11-390): 3.9e-74: 257: 11.49
+	Hs
		556779 CREB1_HUMAN (64-323): 6.09e-26: 107: 14.04		RO52_HUMAN (15-390): 2.55e-68: 241: 12.86
+	Hs
		1081227 NF2L2_HUMAN (8-330): 3.51e-27: 114: 14.71		TRI22_HUMAN (17-328): 1.3e-62: 225: 14.24
+	Hs
		556963 CREB1_HUMAN (64-323): 6.09e-26: 107: 14.04		TRIM5_HUMAN (10-339): 1.37e-63: 227: 13.27
+	Hs
		556914 CREB1_HUMAN (64-323): 6.09e-26: 107: 14.04		TRI22_HUMAN (17-328): 1.3e-62: 225: 14.24
+	Hs
		402389 JUN_HUMAN (1-347): 5.04e-56: 187: 43.89		BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98