HitPredict

Interactor 1: CXA1 (P17302)
Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)
Gene: GJA1

Interactor 2: M4K5 (Q9Y4K4)
Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)
Gene: MAP4K5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 382 Hs			1 846
+	Hs
		566931 CXA1_HUMAN (1-382): 0: 545: 100.00		MARK3_HUMAN (13-559): 3.08e-135: 422: 18.71
+	Hs
		566939 CXA1_HUMAN (1-382): 0: 545: 100.00		AKT2_HUMAN (1-350): 8.02e-130: 398: 22.63
+	Hs
		567131 CXA1_HUMAN (1-382): 0: 545: 100.00		MARK2_HUMAN (2-473): 3.58e-124: 394: 21.36
+	Hs
		566938 CXA1_HUMAN (1-382): 0: 545: 100.00		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38
+	Hs
		567321 CXA1_HUMAN (1-382): 0: 545: 100.00		TNIK_HUMAN (14-295): 1.26e-72: 262: 45.73
+	Hs
		567165 CXA1_HUMAN (1-382): 0: 545: 100.00		MINK1_HUMAN (3-295): 3.13e-70: 254: 45.28
+	Hs
		324735 CXA1_HUMAN (1-382): 0: 545: 100.00		M4K4_HUMAN (2-295): 4.04e-64: 236: 43.51
+	Rn
		251116 CXD2_RAT (1-242): 1.21e-106: 317: 34.27		KCC2A_RAT (8-488): 2.27e-138: 420: 19.47
+	Hs
		647924 CXD3_HUMAN (1-253): 8.84e-96: 289: 34.39		MARK3_HUMAN (13-559): 3.08e-135: 422: 18.71
+	Hs
		1183071 CXD3_HUMAN (1-253): 8.84e-96: 289: 34.39		MARK2_HUMAN (2-473): 3.58e-124: 394: 21.36
+	Hs
		1230271 CXD3_HUMAN (1-253): 8.84e-96: 289: 34.39		MINK1_HUMAN (3-295): 3.13e-70: 254: 45.28