HitPredict

Interactor 1: KAPCA (P17612)
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)
Gene: PRKACA

Interactor 2: CALD1 (Q05682)
Caldesmon (CDM)
Gene: CALD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	2050683
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 351 Hs			1 793
+	Hs
		568689 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		GRDN_HUMAN (28-793): 9.97e-36: 148: 12.77
+	Hs
		984683 AKT3_HUMAN (37-347): 2.7e-148: 428: 41.59		CALD1_HUMAN (1-793): 4.35e-43: 169: 100.00
+	Hs
		522538 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		MYH1_HUMAN (1-788): 6.51e-31: 133: 10.82
+	Hs
		610802 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		MYH4_HUMAN (1-788): 6.02e-31: 133: 10.45
+	Hs
		568568 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		MYH10_HUMAN (55-788): 1.22e-26: 119: 10.63
+	Hs
		681881 AKT1_HUMAN (7-347): 2.89e-149: 430: 38.79		GRDN_HUMAN (28-793): 9.97e-36: 148: 12.77
+	Mm
		1130947 AKT2_MOUSE (18-343): 2.99e-149: 430: 38.18		GRDN_MOUSE (28-793): 4.41e-34: 143: 12.52
+	Mm
		682109 AKT1_MOUSE (7-347): 2.65e-149: 430: 38.79		GRDN_MOUSE (28-793): 4.41e-34: 143: 12.52
+	Hs
		568567 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87
+	Mm
		554901 KPCE_MOUSE (9-351): 4.22e-141: 419: 36.70		MYH6_MOUSE (1-792): 7.67e-30: 129: 10.87
+	Hs
		682219 AKT2_HUMAN (18-343): 1.61e-150: 434: 38.79		MYO5A_HUMAN (42-632): 2.15e-24: 112: 15.29
+	Hs
		551616 AKT1_HUMAN (7-347): 2.89e-149: 430: 38.79		DESP_HUMAN (13-640): 3.03e-22: 105: 14.35
+	Hs
		681696 AKT1_HUMAN (7-347): 2.89e-149: 430: 38.79		MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87
+	Dm
		397193 KPC1_DROME (3-351): 3.07e-140: 414: 36.11		MYSN_DROME (2-660): 2.34e-25: 115: 10.46
+	Hs
		551672 KPCE_HUMAN (9-351): 6.36e-141: 418: 36.42		DESP_HUMAN (13-640): 3.03e-22: 105: 14.35
+	Hs
		724784 KPCE_HUMAN (9-351): 6.36e-141: 418: 36.42		MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87
+	Hs
		234193 AKT1_HUMAN (7-347): 2.89e-149: 430: 38.79		PEPL_HUMAN (15-671): 2.36e-17: 89.5: 8.61
+	Hs
		623875 KPCL_HUMAN (6-351): 1.39e-145: 428: 36.59		PLEC_HUMAN (5-781): 2.36e-17: 89.5: 9.94
+	Mm
		682130 AKT1_MOUSE (7-347): 2.65e-149: 430: 38.79		PEPL_MOUSE (27-700): 2.01e-12: 73.3: 10.60
+	Hs
		217927 PRKY_HUMAN (33-267): 8.27e-92: 277: 52.77		KI16B_HUMAN (113-599): 8.25e-21: 100: 15.99