Protein: KLF4
Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor)

Gene: KLF4
Organism: Homo sapiens
Interactions: 164
UniProt ID: O43474

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000791 - euchromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

216870

SP1
Transcription factor Sp1

2

19

Small-scale

0.768

High

216900

PLK1
Serine/threonine-protein kinase PLK1

1

4

Small-scale

0.724

High

216936

EP300
Histone acetyltransferase p300

5

20

Small-scale

0.707

High

169832

AURKA
Aurora kinase A

1

4

High-throughput

0.691

High

216972

HDAC2
Histone deacetylase 2

3

20

Small-scale

0.667

High

216975

CBP
CREB-binding protein

3

20

Small-scale

0.667

High

216947

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

5

Small-scale

0.634

High

216867

ESR1
Estrogen receptor

3

20

High-throughput

0.633

High

216861

ZEB2
Zinc finger E-box-binding homeobox 2

1

19

High-throughput

0.618

High

216876

ZEP1
Zinc finger protein 40

1

20

High-throughput

0.618

High

216877

EGR1
Early growth response protein 1

1

18

Small-scale

0.618

High

216933

KPCD
Protein kinase C delta type

1

6

Small-scale

0.618

High

216970

ZN516
Zinc finger protein 516

1

19

High-throughput

0.618

High

216987

KLF6
Krueppel-like factor 6

1

19

Small-scale

0.618

High

217004

ZN281
Zinc finger protein 281

1

19

High-throughput

0.618

High

216941

CTBP1
C-terminal-binding protein 1

2

12

Small-scale

0.612

High

169334

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

6

High-throughput

0.606

High

216863

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

216875

GYS1
Glycogen [starch] synthase, muscle

2

1

High-throughput

0.606

High

216902

PAX9
Paired box protein Pax-9

2

3

High-throughput

0.606

High

216935

TLE5
TLE family member 5

2

13

High-throughput

0.606

High

216979

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

13

High-throughput

0.606

High

194488

KDM6A
Lysine-specific demethylase 6A

2

13

Small-scale

0.584

High

216874

CADH1
Cadherin-1

2

2

Small-scale

0.584

High

216937

NFIA
Nuclear factor 1 A-type

2

20

High-throughput

0.584

High

216884

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.561

High

216899

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

Small-scale

0.561

High

216956

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

12

Small-scale

0.561

High

216960

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

12

Small-scale

0.561

High

216978

KAT5
Histone acetyltransferase KAT5

1

6

Small-scale

0.561

High

216951

ZN750
Zinc finger protein 750

1

0

Small-scale

0.549

High

216967

BAALC
Brain and acute leukemia cytoplasmic protein

1

0

Small-scale

0.549

High

216871

ANDR
Androgen receptor

1

20

High-throughput

0.534

High

216868

A4
Amyloid-beta precursor protein

1

18

High-throughput

0.501

High

216894

YAP1
Transcriptional coactivator YAP1

1

20

Small-scale

0.501

High

216942

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.501

High

216965

SETD7
Histone-lysine N-methyltransferase SETD7

1

3

Small-scale

0.501

High

217009

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

134975

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

12

High-throughput

0.500

High

140668

NOP56
Nucleolar protein 56

1

5

High-throughput

0.500

High

216864

RL1D1
Ribosomal L1 domain-containing protein 1

1

5

High-throughput

0.500

High

216865

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

19

High-throughput

0.500

High

216866

MBD3
Methyl-CpG-binding domain protein 3

1

1

Small-scale

0.500

High

216869

LA
Lupus La protein

1

12

High-throughput

0.500

High

216873

PABP1
Polyadenylate-binding protein 1

1

2

High-throughput

0.500

High

216882

RS19
Small ribosomal subunit protein eS19

1

3

High-throughput

0.500

High

216886

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.500

High

216889

NOP2
28S rRNA

1

11

High-throughput

0.500

High

216891

RL27A
Large ribosomal subunit protein uL15

1

8

High-throughput

0.500

High

216892

RS5
Small ribosomal subunit protein uS7

1

10

High-throughput

0.500

High

216893

RS10
Small ribosomal subunit protein eS10

1

8

High-throughput

0.500

High

216895

RL14
Large ribosomal subunit protein eL14

1

3

High-throughput

0.500

High

216896

RT29
Small ribosomal subunit protein mS29

1

3

High-throughput

0.500

High

216905

RS3A
Small ribosomal subunit protein eS1

1

2

High-throughput

0.500

High

216908

RS29
Small ribosomal subunit protein uS14

1

1

High-throughput

0.500

High

216909

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.500

High

216910

RS11
Small ribosomal subunit protein uS17

1

6

High-throughput

0.500

High

216912

RS15
Small ribosomal subunit protein uS19

1

5

High-throughput

0.500

High

216913

RS24
Small ribosomal subunit protein eS24

1

2

High-throughput

0.500

High

216916

RL10A
Large ribosomal subunit protein uL1

1

5

High-throughput

0.500

High

216920

RT35
Small ribosomal subunit protein mS35

1

4

High-throughput

0.500

High

216923

RT15
Small ribosomal subunit protein uS15m

1

3

High-throughput

0.500

High

216928

RL19
Large ribosomal subunit protein eL19

1

3

High-throughput

0.500

High

216929

RL18A
Large ribosomal subunit protein eL20

1

3

High-throughput

0.500

High

216938

ILF2
Interleukin enhancer-binding factor 2

1

7

High-throughput

0.500

High

216940

PABP4
Polyadenylate-binding protein 4

1

2

High-throughput

0.500

High

216945

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

12

High-throughput

0.500

High

216946

RRP5
Protein RRP5 homolog

1

7

High-throughput

0.500

High

216953

ZN326
DBIRD complex subunit ZNF326

1

7

High-throughput

0.500

High

216954

RRP12
RRP12-like protein

1

3

High-throughput

0.500

High

216955

LARP1
La-related protein 1

1

13

High-throughput

0.500

High

216958

DHX30
ATP-dependent RNA helicase DHX30

1

6

High-throughput

0.500

High

216959

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

5

High-throughput

0.500

High

216968

DDX1
ATP-dependent RNA helicase DDX1

1

5

High-throughput

0.500

High

216976

RENT1
Regulator of nonsense transcripts 1

1

1

High-throughput

0.500

High

216984

PTCD3
Small ribosomal subunit protein mS39

1

3

High-throughput

0.500

High

216986

ZFR
Zinc finger RNA-binding protein

1

9

High-throughput

0.500

High

216989

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

11

High-throughput

0.500

High

216991

RT26
Small ribosomal subunit protein mS26

1

3

High-throughput

0.500

High

216992

MOV10
Helicase MOV-10

1

1

High-throughput

0.500

High

216996

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

10

High-throughput

0.500

High

216997

RM15
Large ribosomal subunit protein uL15m

1

1

High-throughput

0.500

High

217006

RT16
Small ribosomal subunit protein bS16m

1

2

High-throughput

0.500

High

217011

RT18B
Small ribosomal subunit protein mS40

1

5

High-throughput

0.500

High

217012

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

11

High-throughput

0.500

High

216907

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.479

High

216914

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.479

High

216926

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.479

High

217008

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.479

High

138545

CLD5
Claudin-5

1

1

Small-scale

0.479

High

138952

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.479

High

154584

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

161376

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

176010

KDM6B
Lysine-specific demethylase 6B

1

13

Small-scale

0.479

High

216872

BCL2
Apoptosis regulator Bcl-2

1

1

Small-scale

0.479

High

216878

ELK1
ETS domain-containing protein Elk-1

1

20

Small-scale

0.479

High

216880

CTNB1
Catenin beta-1

1

12

Small-scale

0.479

High

216881

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.479

High

216883

CUX1
Homeobox protein cut-like 1

1

15

High-throughput

0.479

High

216887

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

5

Small-scale

0.479

High

216888

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

14

Small-scale

0.479

High

216890

NOTC1
Neurogenic locus notch homolog protein 1

1

20

Small-scale

0.479

High

216897

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

19

High-throughput

0.479

High

216898

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

19

High-throughput

0.479

High

216901

ATX3
Ataxin-3

1

1

Small-scale

0.479

High

216903

CTBP2
C-terminal-binding protein 2

1

12

Small-scale

0.479

High

216906

RL26
Large ribosomal subunit protein uL24

1

14

High-throughput

0.479

High

216911

H4
Histone H4

1

6

High-throughput

0.479

High

216927

RL36A
Large ribosomal subunit protein eL42

1

11

High-throughput

0.479

High

216930

TF65
Transcription factor p65

1

15

Small-scale

0.479

High

216931

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.479

High

216934

ZO1
Tight junction protein 1

1

6

Small-scale

0.479

High

216939

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

4

Small-scale

0.479

High

216943

CUL1
Cullin-1

1

20

Small-scale

0.479

High

216944

CUL2
Cullin-2

1

20

Small-scale

0.479

High

216948

TNIP1
TNFAIP3-interacting protein 1

1

13

High-throughput

0.479

High

216950

OCLN
Occludin

1

1

Small-scale

0.479

High

216952

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

2

High-throughput

0.479

High

216957

PAXI1
PAX-interacting protein 1

1

9

High-throughput

0.479

High

216961

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

216963

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

216964

KDM2B
Lysine-specific demethylase 2B

1

11

High-throughput

0.479

High

216966

HDAC7
Histone deacetylase 7

1

20

Small-scale

0.479

High

216973

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

216974

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

216977

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

10

High-throughput

0.479

High

216980

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

15

Small-scale

0.479

High

216981

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

16

Small-scale

0.479

High

216998

RCOR1
REST corepressor 1

1

18

Small-scale

0.479

High

217000

HDAC5
Histone deacetylase 5

1

20

Small-scale

0.479

High

217010

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

217013

NCOA3
Nuclear receptor coactivator 3

1

14

High-throughput

0.479

High

216985

MY15B
Unconventional myosin-XVB

1

5

High-throughput

0.470

High

216885

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

216917

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

216949

ELOB
Elongin-B

1

0

Small-scale

0.458

High

216962

FBX22
F-box only protein 22

1

0

Small-scale

0.458

High

216982

FBX32
F-box only protein 32

1

0

Small-scale

0.458

High

216999

NDRG2
Protein NDRG2

1

0

Small-scale

0.458

High

216862

RT14
Small ribosomal subunit protein uS14m

1

3

High-throughput

0.457

High

216918

RT22
Small ribosomal subunit protein mS22

1

3

High-throughput

0.457

High

216919

RT25
Small ribosomal subunit protein mS25

1

2

High-throughput

0.457

High

216921

RT05
Small ribosomal subunit protein uS5m

1

7

High-throughput

0.457

High

216922

RT11
Small ribosomal subunit protein uS11m

1

3

High-throughput

0.457

High

216924

RT34
Small ribosomal subunit protein mS34

1

4

High-throughput

0.457

High

216925

RT09
Small ribosomal subunit protein uS9m

1

10

High-throughput

0.457

High

216932

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

4

High-throughput

0.457

High

216969

RT27
Small ribosomal subunit protein mS27

1

3

High-throughput

0.457

High

216971

RT31
Small ribosomal subunit protein mS31

1

3

High-throughput

0.457

High

216983

RT24
Small ribosomal subunit protein uS3m

1

2

High-throughput

0.457

High

216988

DDX50
ATP-dependent RNA helicase DDX50

1

8

High-throughput

0.457

High

216990

RM04
Large ribosomal subunit protein uL4m

1

2

High-throughput

0.457

High

216993

ATD3A
ATPase family AAA domain-containing protein 3A

1

9

High-throughput

0.457

High

216994

RM39
Large ribosomal subunit protein mL39

1

1

High-throughput

0.457

High

217001

RT28
Small ribosomal subunit protein bS1m

1

2

High-throughput

0.457

High

217002

RT17
Small ribosomal subunit protein uS17m

1

1

High-throughput

0.457

High

217003

RT07
Small ribosomal subunit protein uS7m

1

10

High-throughput

0.457

High

217005

RT02
Small ribosomal subunit protein uS2m

1

5

High-throughput

0.457

High

217007

RT23
Small ribosomal subunit protein mS23

1

4

High-throughput

0.457

High

216915

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

2

High-throughput

0.445

High

216995

GRHL1
Grainyhead-like protein 1 homolog

1

4

High-throughput

0.445

High

104889

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

216879

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

2

Small-scale

0.437

High

216904

CXCR4
C-X-C chemokine receptor type 4

1

3

Small-scale

0.437

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025