HitPredict

Interactor 1: KAPCA (P17612)
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)
Gene: PRKACA

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	31189917, 32814053
Identification Methods	affinity chromatography technology, pull down, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding and 1 others more... GO:0034605 - cellular response to heat
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 351 Hs			1 303
+	Hs
		609708 KAPCG_HUMAN (1-351): 2.31e-162: 459: 82.91		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		682070 AKT1_HUMAN (7-347): 2.89e-149: 430: 38.79		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Mm
		682131 AKT1_MOUSE (7-347): 2.65e-149: 430: 38.79		CHIP_MOUSE (1-303): 1.23e-67: 214: 97.37
+	Hs
		1354258 KS6B2_HUMAN (7-351): 3.64e-142: 412: 34.08		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		609656 KAPCG_HUMAN (1-351): 2.31e-162: 459: 82.91		PPP5_HUMAN (1-259): 1.3e-35: 135: 20.91
+	Rn
		858690 AKT3_RAT (37-343): 8.56e-147: 424: 42.12		PPP5_RAT (1-259): 9.7e-36: 136: 20.91
+	Hs
		616689 KS6B1_HUMAN (2-351): 1.99e-141: 412: 33.24		PPP5_HUMAN (1-259): 1.3e-35: 135: 20.91
+	Hs
		117035 SGK1_HUMAN (34-342): 1.03e-85: 267: 42.54		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00