Protein: PREX2
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2)

Gene: PREX2
Organism: Homo sapiens
Interactions: 17
UniProt ID: Q70Z35

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

725404

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

2

High-throughput

0.691

High

1015543

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.691

High

839306

MTOR
Serine/threonine-protein kinase mTOR

1

5

Small-scale

0.690

High

955316

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.647

High

962194

RHOA
Transforming protein RhoA

1

20

High-throughput

0.647

High

967816

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

6

Small-scale

0.647

High

988472

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.647

High

1131923

GNMT
Glycine N-methyltransferase

2

1

Small-scale

0.624

High

578507

BRAF
Serine/threonine-protein kinase B-raf

1

5

High-throughput

0.618

High

1258731

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

3

Small-scale

0.584

High

1258732

RHG18
Rho GTPase-activating protein 18

2

8

High-throughput

0.571

High

892260

5NTC
Cytosolic purine 5'-nucleotidase

2

0

High-throughput

0.547

High

1258733

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.515

High

1258734

ASTRA
Protein Aster-A

1

0

High-throughput

0.513

High

1153822

SMAD2
Mothers against decapentaplegic homolog 2

1

5

High-throughput

0.479

High

372382

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.407

High

471100

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025