Protein: KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

Gene: KAP1, PRKAR1B
Organism: Homo sapiens
Interactions: 159
UniProt ID: P31321

Gene Ontology (top 5):
GO:0004862 - cAMP-dependent protein kinase inhibitor activity
GO:0005771 - multivesicular body
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005952 - cAMP-dependent protein kinase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

531006

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

11

19

Small-scale

0.977

High

605568

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

8

20

Small-scale

0.972

High

651617

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

6

20

High-throughput

0.949

High

725355

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

4

18

High-throughput

0.892

High

650524

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

2

20

High-throughput

0.811

High

725457

WNK1
Serine/threonine-protein kinase WNK1

2

13

High-throughput

0.793

High

725364

GSK3A
Glycogen synthase kinase-3 alpha

2

6

High-throughput

0.789

High

291756

STK16
Serine/threonine-protein kinase 16

2

6

High-throughput

0.783

High

725367

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

4

High-throughput

0.783

High

725422

LNX1
E3 ubiquitin-protein ligase LNX

2

5

High-throughput

0.783

High

725455

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

2

4

High-throughput

0.783

High

725426

RPGF5
Rap guanine nucleotide exchange factor 5

2

0

High-throughput

0.770

High

224411

AKA7A
A-kinase anchor protein 7 isoforms alpha and beta

2

8

High-throughput

0.759

High

725469

AKA7G
A-kinase anchor protein 7 isoform gamma

2

8

High-throughput

0.757

High

725365

GSK3B
Glycogen synthase kinase-3 beta

2

6

High-throughput

0.754

High

725354

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

17

Small-scale

0.713

High

725400

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

1

High-throughput

0.700

High

725381

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.691

High

725404

PREX2
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

1

2

High-throughput

0.691

High

725467

RAI14
Ankycorbin

1

2

High-throughput

0.691

High

332883

VAPB
Vesicle-associated membrane protein-associated protein B/C

3

6

High-throughput

0.667

High

725468

VAPA
Vesicle-associated membrane protein-associated protein A

3

6

High-throughput

0.662

High

725463

PICK1
PRKCA-binding protein

1

0

High-throughput

0.656

High

725376

SKP2
S-phase kinase-associated protein 2

2

2

High-throughput

0.628

High

725418

GP161
G-protein coupled receptor 161

2

2

High-throughput

0.628

High

725443

NOX5
NADPH oxidase 5

2

8

High-throughput

0.628

High

725444

ERMAP
Erythroid membrane-associated protein

2

1

High-throughput

0.628

High

725428

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

3

High-throughput

0.621

High

244227

NUAK1
NUAK family SNF1-like kinase 1

1

4

High-throughput

0.618

High

603178

KPCA
Protein kinase C alpha type

1

11

High-throughput

0.618

High

725380

CUL3
Cullin-3

2

3

High-throughput

0.611

High

725436

AP2M1
AP-2 complex subunit mu

2

1

High-throughput

0.611

High

725449

SYT11
Synaptotagmin-11

2

2

High-throughput

0.611

High

725448

SNAG
Gamma-soluble NSF attachment protein

3

4

High-throughput

0.609

High

362841

EGFR
Epidermal growth factor receptor

2

3

Small-scale

0.608

High

262367

DTNB
Dystrobrevin beta

2

3

High-throughput

0.606

High

319201

FCSD2
F-BAR and double SH3 domains protein 2

2

1

High-throughput

0.606

High

337451

PSMG1
Proteasome assembly chaperone 1

2

1

High-throughput

0.606

High

533250

THA
Thyroid hormone receptor alpha

2

4

High-throughput

0.606

High

725356

KINH
Kinesin-1 heavy chain

2

3

High-throughput

0.606

High

725363

BAG6
Large proline-rich protein BAG6

2

1

High-throughput

0.606

High

725374

ZBT16
Zinc finger and BTB domain-containing protein 16

2

2

High-throughput

0.606

High

725390

QRIC1
Transcriptional regulator QRICH1

2

1

High-throughput

0.606

High

725399

TASO2
Protein TASOR 2

2

3

High-throughput

0.606

High

725407

AKA28
A-kinase anchor protein 14

2

2

High-throughput

0.606

High

725421

GA2L2
GAS2-like protein 2

2

1

High-throughput

0.606

High

725425

SHC3
SHC-transforming protein 3

2

10

High-throughput

0.606

High

725427

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

10

High-throughput

0.606

High

725430

GOGA1
Golgin subfamily A member 1

2

2

High-throughput

0.606

High

725435

SYTL4
Synaptotagmin-like protein 4

2

3

High-throughput

0.606

High

725460

SH24A
SH2 domain-containing protein 4A

2

4

High-throughput

0.606

High

725465

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

2

1

High-throughput

0.606

High

725471

NXF1
Nuclear RNA export factor 1

2

1

High-throughput

0.606

High

725366

PGTB2
Geranylgeranyl transferase type-2 subunit beta

2

0

High-throughput

0.585

High

347549

BAG3
BAG family molecular chaperone regulator 3

2

0

High-throughput

0.580

High

725361

CDN1A
Cyclin-dependent kinase inhibitor 1

2

0

High-throughput

0.580

High

725386

PI5PA
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

2

0

High-throughput

0.580

High

725387

CDC37
Hsp90 co-chaperone Cdc37

2

0

High-throughput

0.580

High

725391

F161A
Protein FAM161A

2

0

High-throughput

0.580

High

725437

ZMY19
Zinc finger MYND domain-containing protein 19

2

0

High-throughput

0.580

High

725438

EF2KT
Protein-lysine N-methyltransferase EEF2KMT

2

0

High-throughput

0.580

High

725440

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

725442

CEP19
Centrosomal protein of 19 kDa

2

0

High-throughput

0.580

High

725456

SMG9
Nonsense-mediated mRNA decay factor SMG9

2

0

High-throughput

0.580

High

725473

DACH1
Dachshund homolog 1

2

0

High-throughput

0.580

High

725398

CAMP1
Calmodulin-regulated spectrin-associated protein 1

2

1

High-throughput

0.561

High

565509

RARG
Retinoic acid receptor gamma

2

6

High-throughput

0.553

High

567168

ZNF35
Zinc finger protein 35

2

2

High-throughput

0.553

High

725362

GUC1A
Guanylyl cyclase-activating protein 1

2

1

High-throughput

0.553

High

725375

MTG8
Protein CBFA2T1

2

2

High-throughput

0.553

High

725377

ZN177
Zinc finger protein 177

2

1

High-throughput

0.553

High

725383

VEZF1
Vascular endothelial zinc finger 1

2

4

High-throughput

0.553

High

725408

IGFN1
Immunoglobulin-like and fibronectin type III domain-containing protein 1

2

3

High-throughput

0.553

High

725409

ZN410
Zinc finger protein 410

2

4

High-throughput

0.553

High

725454

GLIS2
Zinc finger protein GLIS2

2

5

High-throughput

0.553

High

725461

CBX8
Chromobox protein homolog 8

2

1

High-throughput

0.553

High

725462

DPOE4
DNA polymerase epsilon subunit 4

2

2

High-throughput

0.553

High

725429

AKAP1
A-kinase anchor protein 1, mitochondrial

1

3

Small-scale

0.552

High

273491

DJC13
DnaJ homolog subfamily C member 13

1

2

High-throughput

0.536

High

341904

CEP43
Centrosomal protein 43

1

1

High-throughput

0.536

High

457253

TBB5
Tubulin beta chain

1

3

High-throughput

0.536

High

563044

MYH8
Myosin-8

1

1

High-throughput

0.536

High

725405

FLIP1
Filamin-A-interacting protein 1

1

2

High-throughput

0.536

High

725453

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.536

High

725474

AKA11
A-kinase anchor protein 11

1

5

High-throughput

0.536

High

635295

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.513

High

725368

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.513

High

725378

PLD1
Phospholipase D1

1

0

High-throughput

0.513

High

725382

AT1A4
Sodium/potassium-transporting ATPase subunit alpha-4

1

0

High-throughput

0.513

High

725388

DOXA2
Dual oxidase maturation factor 2

1

0

High-throughput

0.513

High

725403

ZN746
Zinc finger protein 746

1

0

High-throughput

0.513

High

725413

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.513

High

507578

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

High-throughput

0.501

High

725446

LGMN
Legumain

1

0

High-throughput

0.493

High

214480

ZN749
Zinc finger protein 749

1

1

High-throughput

0.489

High

556901

MYH7
Myosin-7

1

1

High-throughput

0.489

High

725393

TBB8
Tubulin beta-8 chain

1

3

High-throughput

0.489

High

725416

FA43A
Protein FAM43A

1

3

High-throughput

0.489

High

725419

FRMD1
FERM domain-containing protein 1

1

4

High-throughput

0.489

High

725450

AASD1
Alanyl-tRNA editing protein Aarsd1

1

1

High-throughput

0.489

High

725466

KLH28
Kelch-like protein 28

1

1

High-throughput

0.489

High

172502

XPO1
Exportin-1

1

4

High-throughput

0.479

High

725371

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

725459

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

725394

Q49AR9
ANKS1A protein

1

3

High-throughput

0.470

High

725441

MY15B
Unconventional myosin-XVB

1

4

High-throughput

0.470

High

725370

CDC42
Cell division control protein 42 homolog

1

4

Small-scale

0.457

High

725372

UBC9
SUMO-conjugating enzyme UBC9

1

5

High-throughput

0.457

High

725464

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

725475

S27A6
Long-chain fatty acid transport protein 6

1

2

High-throughput

0.445

High

533601

CLUS
Clusterin

1

0

High-throughput

0.438

High

371276

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.407

High

725401

CRBG3
Very large A-kinase anchor protein

1

1

High-throughput

0.407

High

725420

GG6L2
Golgin subfamily A member 6-like protein 2

1

5

High-throughput

0.407

High

725369

MLF1
Myeloid leukemia factor 1

3

0

High-throughput

0.347

High

725402

SFRP4
Secreted frizzled-related protein 4

3

0

High-throughput

0.347

High

240061

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

0

High-throughput

0.328

High

725360

ETFB
Electron transfer flavoprotein subunit beta

2

0

High-throughput

0.328

High

725373

RT15
Small ribosomal subunit protein uS15m

2

0

High-throughput

0.328

High

725397

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

352081

MBD3
Methyl-CpG-binding domain protein 3

2

0

High-throughput

0.316

High

528424

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

2

0

High-throughput

0.316

High

725359

ZNF76
Zinc finger protein 76

2

0

High-throughput

0.316

High

725379

SNW1
SNW domain-containing protein 1

2

0

High-throughput

0.316

High

725385

TEAD4
Transcriptional enhancer factor TEF-3

2

0

High-throughput

0.316

High

725392

T10IP
Testis-specific protein 10-interacting protein

2

0

High-throughput

0.316

High

725406

ZN329
Zinc finger protein 329

2

0

High-throughput

0.316

High

725410

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

725411

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.316

High

725412

DAA19
Dynein axonemal assembly factor 19

2

0

High-throughput

0.316

High

725415

BD1L2
Biorientation of chromosomes in cell division protein 1-like 2

2

0

High-throughput

0.316

High

725432

GPKOW
G-patch domain and KOW motifs-containing protein

2

0

High-throughput

0.316

High

725433

LMBL2
Lethal(3)malignant brain tumor-like protein 2

2

0

High-throughput

0.316

High

725434

LENG1
Leukocyte receptor cluster member 1

2

0

High-throughput

0.316

High

725439

MED8
Mediator of RNA polymerase II transcription subunit 8

2

0

High-throughput

0.316

High

725447

PRP18
Pre-mRNA-splicing factor 18

2

0

High-throughput

0.316

High

725472

S30BP
SAP30-binding protein

2

0

High-throughput

0.316

High

270999

ZN623
Zinc finger protein 623

1

0

High-throughput

0.279

Low

296096

GATB
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

1

0

High-throughput

0.279

Low

562702

BMP1
Bone morphogenetic protein 1

1

0

High-throughput

0.279

Low

568366

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

725357

MCM5
DNA replication licensing factor MCM5

1

0

High-throughput

0.279

Low

725358

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.279

Low

725384

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.279

Low

725389

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

725395

GREB1
Protein GREB1

1

0

High-throughput

0.279

Low

725396

TFDP3
Transcription factor Dp family member 3

1

0

High-throughput

0.279

Low

725414

IQCF2
IQ domain-containing protein F2

1

0

High-throughput

0.279

Low

725417

CQ078
Uncharacterized protein C17orf78

1

0

High-throughput

0.279

Low

725423

ZN564
Zinc finger protein 564

1

0

High-throughput

0.279

Low

725424

ZN507
Zinc finger protein 507

1

0

High-throughput

0.279

Low

725431

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.279

Low

725451

CCD32
Coiled-coil domain-containing protein 32

1

0

High-throughput

0.279

Low

725452

TALD3
Protein TALPID3

1

0

High-throughput

0.279

Low

725458

SENP3
Sentrin-specific protease 3

1

0

High-throughput

0.279

Low

725470

MAP10
Microtubule-associated protein 10

1

0

High-throughput

0.279

Low

455705

H10
Histone H1.0

1

0

High-throughput

0.269

Low

725445

DCR1C
Protein artemis

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025