HitPredict

Interactor 1: CAN2 (P17655)
Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)
Gene: CAPN2

Interactor 2: ICAL (P20810)
Calpastatin (Calpain inhibitor) (Sperm BS-17 component)
Gene: CAST

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 18519038
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, nuclear magnetic resonance
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Calpain_III~Calpain_inhib, Calpain_inhib~EF-hand_8, Calpain_inhib~Peptidase_C2
Common GO terms	GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 700 Hs			1 708
+	Hs
		427843 CAN1_HUMAN (3-700): 0: 915: 62.20		ICAL_HUMAN (1-708): 1.39e-102: 331: 100.00
+	Hs
		62712 CAN8_HUMAN (1-699): 0: 900: 61.40		ICAL_HUMAN (1-708): 1.39e-102: 331: 100.00
+	Rn
		646586 CAN2_RAT (1-700): 0: 935: 93.71		ICAL_RAT (4-708): 1.91e-77: 264: 61.02
+	Hs
		595836 CAN3_HUMAN (3-700): 0: 863: 43.42		TITIN_HUMAN (25-582): 4.76e-11: 69: 11.15
+	Hs
		595882 CPNS2_HUMAN (498-700): 9.34e-53: 184: 40.20		ICAL_HUMAN (1-708): 1.39e-102: 331: 100.00