Protein: CXCR2
C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182)

Gene: CXCR2
Organism: Homo sapiens
Interactions: 60
UniProt ID: P25025

Gene Ontology (top 5):
GO:0002407 - dendritic cell chemotaxis
GO:0004918 - interleukin-8 receptor activity
GO:0004930 - G protein-coupled receptor activity
GO:0005654 - nucleoplasm
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

518766

IL8
Interleukin-8

18

20

Small-scale

0.985

High

480487

GROA
Growth-regulated alpha protein

9

20

Small-scale

0.957

High

390321

CXCL7
Platelet basic protein

3

20

Small-scale

0.827

High

668216

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

2

1

High-throughput

0.783

High

668197

CXCR2
C-X-C chemokine receptor type 2

2

18

Small-scale

0.776

High

668201

CXCL5
C-X-C motif chemokine 5

2

20

Small-scale

0.776

High

668215

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

18

Small-scale

0.665

High

668200

GRIA1
Glutamate receptor 1

3

7

Small-scale

0.640

High

626420

CXCL2
C-X-C motif chemokine 2

1

20

Small-scale

0.618

High

626439

CXCL3
C-X-C motif chemokine 3

1

20

Small-scale

0.618

High

668188

CXCR1
C-X-C chemokine receptor type 1

1

18

Small-scale

0.618

High

668203

ARRB1
Beta-arrestin-1

1

12

Small-scale

0.618

High

668211

CXCL6
C-X-C motif chemokine 6

1

20

Small-scale

0.618

High

668206

EMP1
Epithelial membrane protein 1

2

4

High-throughput

0.606

High

668213

VMAT2
Synaptic vesicular amine transporter

2

3

High-throughput

0.606

High

668223

CLD22
Claudin-22

2

4

High-throughput

0.606

High

668228

TMM80
Transmembrane protein 80

2

1

High-throughput

0.606

High

668232

AT131
Endoplasmic reticulum transmembrane helix translocase

2

20

High-throughput

0.606

High

668233

S39A2
Zinc transporter ZIP2

2

9

High-throughput

0.606

High

668202

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

4

Small-scale

0.599

High

668230

TM147
BOS complex subunit TMEM147

2

0

High-throughput

0.580

High

668234

SMCO4
Single-pass membrane and coiled-coil domain-containing protein 4

2

0

High-throughput

0.580

High

668217

LASP1
LIM and SH3 domain protein 1

2

5

Small-scale

0.567

High

668207

TERA
Transitional endoplasmic reticulum ATPase

1

2

Small-scale

0.536

High

668208

1433G
14-3-3 protein gamma

1

8

Small-scale

0.536

High

668204

F10A1
Hsc70-interacting protein

1

3

Small-scale

0.535

High

407035

HG2A
HLA class II histocompatibility antigen gamma chain

1

3

Small-scale

0.515

High

668226

TF3A
Transcription factor IIIA

1

1

Small-scale

0.515

High

63637

A5PKU2
TUSC5 protein

1

7

High-throughput

0.515

High

179462

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

Small-scale

0.513

High

668205

VASP
Vasodilator-stimulated phosphoprotein

1

0

Small-scale

0.513

High

668222

TARG1
Trafficking regulator of GLUT4 1

1

7

High-throughput

0.481

High

570835

MIF
Macrophage migration inhibitory factor

1

0

Small-scale

0.480

High

668199

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

4

Small-scale

0.479

High

668221

RFIP2
Rab11 family-interacting protein 2

1

4

Small-scale

0.479

High

668227

TF3B
Transcription factor IIIB 90 kDa subunit

1

2

Small-scale

0.479

High

668210

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

Small-scale

0.458

High

668236

MYO5B
Unconventional myosin-Vb

1

0

Small-scale

0.458

High

178904

SCAM2
Secretory carrier-associated membrane protein 2

1

5

Small-scale

0.445

High

402854

ANXA1
Annexin A1

1

3

Small-scale

0.445

High

568119

PLSL
Plastin-2

1

6

Small-scale

0.445

High

668198

PSA2
Proteasome subunit alpha type-2

1

1

Small-scale

0.445

High

668209

1433Z
14-3-3 protein zeta/delta

1

8

Small-scale

0.445

High

668212

CLH1
Clathrin heavy chain 1

1

1

Small-scale

0.445

High

668214

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

Small-scale

0.445

High

668231

KLC2
Kinesin light chain 2

1

1

Small-scale

0.445

High

668237

TLN1
Talin-1

1

6

Small-scale

0.445

High

668219

GASP1
G-protein coupled receptor-associated sorting protein 1

1

6

Small-scale

0.437

High

668220

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.437

High

668224

DYH5
Dynein axonemal heavy chain 5

1

1

Small-scale

0.437

High

127878

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

Small-scale

0.426

High

179305

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.426

High

442238

GELS
Gelsolin

1

0

Small-scale

0.426

High

668218

LIN41
E3 ubiquitin-protein ligase TRIM71

1

1

Small-scale

0.407

High

668235

DYH17
Dynein axonemal heavy chain 17

1

1

Small-scale

0.407

High

668225

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

2

0

High-throughput

0.316

High

668229

NIPS1
Protein NipSnap homolog 1

1

0

Small-scale

0.279

Low

139092

FAAH1
Fatty-acid amide hydrolase 1

1

0

Small-scale

0.249

Low

610533

TCPA
T-complex protein 1 subunit alpha

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025