HitPredict

Interactor 1: DOC11 (A2AF47)
Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2)
Gene: Dock11

Interactor 2: CDC42 (P60766)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15710388
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras, PH~Ras
Common GO terms	GO:0051491 - positive regulation of filopodium assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2073 Mm			1 191
+	Hs
		564557 DOC11_HUMAN (1-2073): 0: 2766: 96.62		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		1127531 DOC11_HUMAN (1-2073): 0: 2766: 96.62		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		925332 DOC11_HUMAN (1-2073): 0: 2766: 96.62		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		894099 DOC11_HUMAN (1-2073): 0: 2766: 96.62		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		545421 DOC11_HUMAN (1-2073): 0: 2766: 96.62		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		892410 DOC11_HUMAN (1-2073): 0: 2766: 96.62		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		564671 DOCK9_HUMAN (2-2035): 0: 2542: 59.00		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Mm
		101404 F8VPN7_MOUSE (30-2062): 0: 2558: 58.69		CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00
+	Hs
		1317682 DOCK9_HUMAN (2-2035): 0: 2542: 59.00		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		925588 DOCK9_HUMAN (2-2035): 0: 2542: 59.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		894393 DOCK9_HUMAN (2-2035): 0: 2542: 59.00		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		951301 DOCK9_HUMAN (2-2035): 0: 2542: 59.00		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		545596 DOCK9_HUMAN (2-2035): 0: 2542: 59.00		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		892573 DOCK9_HUMAN (2-2035): 0: 2542: 59.00		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Mm
		892732 DOC10_MOUSE (4-2073): 0: 2374: 49.23		CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00
+	Hs
		894298 DOC10_HUMAN (4-2049): 0: 2357: 49.66		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	At
		1248269 SPK1_ARATH (339-2038): 0: 1276: 21.59		RAC9_ARATH (4-191): 2.08e-74: 224: 51.81
+	Hs
		925429 DOCK4_HUMAN (1173-2045): 1.21e-163: 555: 15.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		925425 DOCK3_HUMAN (394-1303): 2.34e-106: 382: 12.12		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		545535 DOCK2_HUMAN (394-1079): 1.85e-89: 327: 16.01		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75