Protein: ARHG2
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)

Gene: ARHG2, ARHGEF2
Organism: Homo sapiens
Interactions: 200
UniProt ID: Q92974

Gene Ontology (top 5):
GO:0000902 - cell morphogenesis
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005819 - spindle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

962349

RHOA
Transforming protein RhoA

8

20

Small-scale

0.966

High

1371043

ARHG2
Rho guanine nucleotide exchange factor 2

3

16

Small-scale

0.827

High

978214

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1371073

ANLN
Anillin

2

4

High-throughput

0.754

High

990578

1433Z
14-3-3 protein zeta/delta

7

20

Small-scale

0.745

High

691311

1433T
14-3-3 protein theta

5

20

Small-scale

0.722

High

966706

1433G
14-3-3 protein gamma

5

20

High-throughput

0.716

High

1270489

MARK2
Serine/threonine-protein kinase MARK2

4

5

Small-scale

0.702

High

730123

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.699

High

1049641

1433F
14-3-3 protein eta

4

20

High-throughput

0.699

High

143677

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

4

5

Small-scale

0.697

High

177280

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

3

9

Small-scale

0.675

High

522715

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

5

Small-scale

0.662

High

372757

MYC
Myc proto-oncogene protein

3

10

High-throughput

0.662

High

717923

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

3

2

High-throughput

0.662

High

988587

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.647

High

692111

MARK3
MAP/microtubule affinity-regulating kinase 3

2

5

Small-scale

0.646

High

971851

1433E
14-3-3 protein epsilon

2

8

High-throughput

0.640

High

994322

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

4

High-throughput

0.628

High

1371081

PAK5
Serine/threonine-protein kinase PAK 5

2

20

High-throughput

0.628

High

1371095

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

2

3

Small-scale

0.621

High

157704

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.618

High

159382

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

20

Small-scale

0.618

High

401247

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

11

High-throughput

0.618

High

594071

NCK1
SH2/SH3 adapter protein NCK1

1

20

Small-scale

0.618

High

619088

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

3

Small-scale

0.618

High

720294

UFO
Tyrosine-protein kinase receptor UFO

1

20

High-throughput

0.618

High

942798

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

18

High-throughput

0.618

High

1088200

MERTK
Tyrosine-protein kinase Mer

1

20

High-throughput

0.618

High

1217546

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

11

High-throughput

0.618

High

1254920

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.618

High

1371066

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1371069

PKHA5
Pleckstrin homology domain-containing family A member 5

1

19

Small-scale

0.618

High

1371071

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.618

High

1371090

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

11

Small-scale

0.618

High

979113

RS6
Small ribosomal subunit protein eS6

3

0

High-throughput

0.613

High

1371060

WDR83
WD repeat domain-containing protein 83

3

12

High-throughput

0.609

High

977554

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

2

4

Small-scale

0.601

High

278923

PEX14
Peroxisomal membrane protein PEX14

2

1

Small-scale

0.588

High

991898

DYLT1
Dynein light chain Tctex-type 1

1

2

Small-scale

0.586

High

242495

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

354750

PAK4
Serine/threonine-protein kinase PAK 4

2

17

Small-scale

0.584

High

537646

HSP7C
Heat shock cognate 71 kDa protein

2

2

High-throughput

0.584

High

696124

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

3

High-throughput

0.584

High

768812

RFA3
Replication protein A 14 kDa subunit

2

1

High-throughput

0.584

High

831178

CCNF
Cyclin-F

2

4

High-throughput

0.584

High

1123745

DCTN1
Dynactin subunit 1

2

5

High-throughput

0.584

High

1140651

KIF14
Kinesin-like protein KIF14

2

7

Small-scale

0.584

High

1210937

CE170
Centrosomal protein of 170 kDa

2

6

Small-scale

0.584

High

178094

FYB1
FYN-binding protein 1

1

4

Small-scale

0.575

High

396656

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1096472

PAK1
Serine/threonine-protein kinase PAK 1

1

18

Small-scale

0.561

High

1122032

EFR3A
Protein EFR3 homolog A

2

0

High-throughput

0.559

High

965139

WDR5
WD repeat-containing protein 5

2

12

Small-scale

0.558

High

1371091

HECD1
E3 ubiquitin-protein ligase HECTD1

2

7

High-throughput

0.558

High

219742

FOXO3
Forkhead box protein O3

1

2

High-throughput

0.554

High

1341217

IKBD
NF-kappa-B inhibitor delta

2

12

High-throughput

0.553

High

477250

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

20

High-throughput

0.553

High

1371088

PNMA2
Paraneoplastic antigen Ma2

2

3

High-throughput

0.549

High

220615

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

High-throughput

0.546

High

504750

FBSP1
F-box/SPRY domain-containing protein 1

1

17

High-throughput

0.536

High

765769

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.536

High

857522

NOTC1
Neurogenic locus notch homolog protein 1

1

7

High-throughput

0.536

High

1111162

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

1143900

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

3

High-throughput

0.536

High

1143934

2A5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

1

3

High-throughput

0.536

High

1335942

ZBT44
Zinc finger and BTB domain-containing protein 44

1

4

High-throughput

0.536

High

1371045

SPSB4
SPRY domain-containing SOCS box protein 4

1

17

High-throughput

0.536

High

1371046

TRI52
E3 ubiquitin-protein ligase TRIM52

1

4

High-throughput

0.536

High

1371047

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

1371048

ARRD3
Arrestin domain-containing protein 3

1

5

High-throughput

0.536

High

1371052

MARK4
MAP/microtubule affinity-regulating kinase 4

1

5

High-throughput

0.536

High

1371057

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.536

High

1371058

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

18

High-throughput

0.536

High

1371063

UBXN6
UBX domain-containing protein 6

1

2

High-throughput

0.536

High

1371067

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.536

High

589328

RFA2
Replication protein A 32 kDa subunit

2

2

High-throughput

0.533

High

273696

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

6

Small-scale

0.515

High

730813

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

1204777

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

4

Small-scale

0.515

High

842468

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.513

High

1259053

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

0

High-throughput

0.513

High

1340064

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

0

High-throughput

0.513

High

1371098

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

74565

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

7

High-throughput

0.489

High

1314190

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

7

High-throughput

0.489

High

127790

IKBE
NF-kappa-B inhibitor epsilon

1

8

High-throughput

0.479

High

132207

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

138934

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

1

4

High-throughput

0.479

High

176859

DCLK1
Serine/threonine-protein kinase DCLK1

1

13

Small-scale

0.479

High

227121

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

363674

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

404293

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

410980

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.479

High

412387

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

472949

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

9

High-throughput

0.479

High

484197

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.479

High

530174

TAU
Microtubule-associated protein tau

1

5

Small-scale

0.479

High

541624

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

568273

PLST
Plastin-3

1

14

Small-scale

0.479

High

610033

VGFR1
Vascular endothelial growth factor receptor 1

1

17

High-throughput

0.479

High

703674

MK01
Mitogen-activated protein kinase 1

1

5

Small-scale

0.479

High

777740

VGFR3
Vascular endothelial growth factor receptor 3

1

20

High-throughput

0.479

High

878528

PAXI
Paxillin

1

16

Small-scale

0.479

High

879333

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.479

High

904999

MECP2
Methyl-CpG-binding protein 2

1

9

High-throughput

0.479

High

920161

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.479

High

970877

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

984227

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

10

High-throughput

0.479

High

1024740

VIGLN
Vigilin

1

2

High-throughput

0.479

High

1035823

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

1040880

MECOM
Histone-lysine N-methyltransferase MECOM

1

2

High-throughput

0.479

High

1065748

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

15

Small-scale

0.479

High

1091643

TAF10
Transcription initiation factor TFIID subunit 10

1

2

High-throughput

0.479

High

1113909

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1124512

MAP7
Ensconsin

1

20

Small-scale

0.479

High

1131695

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

3

Small-scale

0.479

High

1137912

TNIP1
TNFAIP3-interacting protein 1

1

14

High-throughput

0.479

High

1138469

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

1152183

MARE1
Microtubule-associated protein RP/EB family member 1

1

6

Small-scale

0.479

High

1204214

PDZ11
PDZ domain-containing protein 11

1

20

Small-scale

0.479

High

1213184

CAMP1
Calmodulin-regulated spectrin-associated protein 1

1

3

Small-scale

0.479

High

1226585

MAP1S
Microtubule-associated protein 1S

1

3

Small-scale

0.479

High

1227199

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.479

High

1276589

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1278203

CLAP1
CLIP-associating protein 1

1

2

Small-scale

0.479

High

1280894

CNTRL
Centriolin

1

6

High-throughput

0.479

High

1309232

KSR1
Kinase suppressor of Ras 1

1

18

Small-scale

0.479

High

1309941

MA7D3
MAP7 domain-containing protein 3

1

5

Small-scale

0.479

High

1314346

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.479

High

1329794

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

1340635

NEDD1
Protein NEDD1

1

7

Small-scale

0.479

High

1360792

ASB11
Ankyrin repeat and SOCS box protein 11

1

5

High-throughput

0.479

High

1366947

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1368030

HDAC2
Histone deacetylase 2

1

7

High-throughput

0.479

High

1371044

FBXW7
F-box/WD repeat-containing protein 7

1

13

High-throughput

0.479

High

1371050

RNF31
E3 ubiquitin-protein ligase RNF31

1

13

High-throughput

0.479

High

1371053

SCLT1
Sodium channel and clathrin linker 1

1

14

High-throughput

0.479

High

1371055

MA7D2
MAP7 domain-containing protein 2

1

14

Small-scale

0.479

High

1371059

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1371062

CP250
Centrosome-associated protein CEP250

1

11

High-throughput

0.479

High

1371064

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

1371065

VP33B
Vacuolar protein sorting-associated protein 33B

1

3

High-throughput

0.479

High

1371070

PRD16
Histone-lysine N-methyltransferase PRDM16

1

3

High-throughput

0.479

High

1371076

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1371082

HDAC6
Protein deacetylase HDAC6

1

12

High-throughput

0.479

High

1371083

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

1371084

EVL
Ena/VASP-like protein

1

7

High-throughput

0.479

High

1371085

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

2

Small-scale

0.479

High

1371086

TLK1
Serine/threonine-protein kinase tousled-like 1

1

7

High-throughput

0.479

High

1371087

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.479

High

1371089

MTUS1
Microtubule-associated tumor suppressor 1

1

16

Small-scale

0.479

High

1371092

FZR1
Fizzy-related protein homolog

1

11

High-throughput

0.479

High

1371093

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.479

High

1371096

MARE3
Microtubule-associated protein RP/EB family member 3

1

6

High-throughput

0.479

High

1371097

C170B
Centrosomal protein of 170 kDa protein B

1

6

Small-scale

0.479

High

315841

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

319953

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

859658

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.458

High

884379

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

934956

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

956175

SRP54
Signal recognition particle subunit SRP54

1

0

Small-scale

0.458

High

1193657

MAP9
Microtubule-associated protein 9

1

0

Small-scale

0.458

High

1218621

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

1246907

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1359528

CKAP2
Cytoskeleton-associated protein 2

1

0

Small-scale

0.458

High

1366495

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1371049

SKA1
SKA complex subunit 1

1

0

Small-scale

0.458

High

1371051

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1371056

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1371061

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

1371074

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

1371079

GTSE1
G2 and S phase-expressed protein 1

1

0

Small-scale

0.458

High

140389

SDCB1
Syntenin-1

1

20

High-throughput

0.445

High

564161

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.445

High

1371054

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1371068

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

180006

BET1
BET1 homolog

1

1

High-throughput

0.437

High

465601

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.437

High

787060

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

18

High-throughput

0.437

High

1249077

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1250183

LRC31
Leucine-rich repeat-containing protein 31

1

3

High-throughput

0.437

High

1326290

NIN
Ninein

1

18

High-throughput

0.437

High

1333064

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

9

Small-scale

0.437

High

887083

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

1328024

RP25L
Ribonuclease P protein subunit p25-like protein

6

0

High-throughput

0.383

High

1065013

FGL1
Fibrinogen-like protein 1

3

0

High-throughput

0.347

High

1308133

LUR1L
Leucine rich adaptor protein 1-like

1

0

High-throughput

0.279

Low

70952

IQCF5
IQ domain-containing protein F5

1

0

High-throughput

0.249

Low

279443

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

1211492

FREM2
FRAS1-related extracellular matrix protein 2

1

0

High-throughput

0.249

Low

1371072

RTN4
Reticulon-4

1

0

High-throughput

0.249

Low

1371075

TNR19
Tumor necrosis factor receptor superfamily member 19

1

0

High-throughput

0.249

Low

1371077

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.249

Low

1371078

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

1371094

RL26L
Ribosomal protein uL24-like

1

0

High-throughput

0.249

Low

344274

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

1231574

TBC3G
TBC1 domain family member 3G

1

0

High-throughput

0.232

Low

1371080

USE1
Vesicle transport protein USE1

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025