Protein: FOXO3
Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)

Gene: FOXO3
Organism: Homo sapiens
Interactions: 96
UniProt ID: O43524

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

219741

CBP
CREB-binding protein

4

20

Small-scale

0.902

High

219725

EP300
Histone acetyltransferase p300

3

20

Small-scale

0.847

High

219701

1433B
14-3-3 protein beta/alpha

7

20

Small-scale

0.747

High

219716

1433Z
14-3-3 protein zeta/delta

8

20

Small-scale

0.747

High

219714

1433E
14-3-3 protein epsilon

5

6

Small-scale

0.716

High

219719

FOXK1
Forkhead box protein K1

1

19

High-throughput

0.715

High

219723

1433F
14-3-3 protein eta

5

20

High-throughput

0.709

High

219744

SIR1
NAD-dependent protein deacetylase sirtuin-1

4

13

Small-scale

0.704

High

219713

1433G
14-3-3 protein gamma

4

20

High-throughput

0.691

High

219693

1433T
14-3-3 protein theta

4

20

Small-scale

0.683

High

219721

MDM2
E3 ubiquitin-protein ligase Mdm2

4

4

Small-scale

0.676

High

219728

SKP2
S-phase kinase-associated protein 2

3

6

Small-scale

0.664

High

219731

SMAD4
Mothers against decapentaplegic homolog 4

2

19

Small-scale

0.654

High

219681

P53
Cellular tumor antigen p53

3

14

Small-scale

0.646

High

219718

SMAD3
Mothers against decapentaplegic homolog 3

2

19

Small-scale

0.641

High

219700

AKT1
RAC-alpha serine/threonine-protein kinase

3

12

Small-scale

0.641

High

219711

PLK1
Serine/threonine-protein kinase PLK1

2

8

Small-scale

0.634

High

167772

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

8

Small-scale

0.624

High

219729

ATM
Serine-protein kinase ATM

2

9

Small-scale

0.624

High

219724

FOXM1
Forkhead box protein M1

1

19

Small-scale

0.618

High

219740

ESR2
Estrogen receptor beta

2

20

Small-scale

0.612

High

177743

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

8

Small-scale

0.597

High

219734

PTPA
Serine/threonine-protein phosphatase 2A activator

2

1

Small-scale

0.595

High

219697

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

5

Small-scale

0.588

High

219747

ATGA1
Autophagy-related protein 101

2

0

Small-scale

0.585

High

219691

H2AX
Histone H2AX

2

7

Small-scale

0.584

High

219703

CTNB1
Catenin beta-1

2

13

Small-scale

0.584

High

219743

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

10

Small-scale

0.584

High

219757

FBW1A
F-box/WD repeat-containing protein 1A

1

16

Small-scale

0.578

High

71806

FOXO6
Forkhead box protein O6

1

16

High-throughput

0.575

High

219671

FOXO3
Forkhead box protein O3

1

18

High-throughput

0.575

High

219715

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

2

3

Small-scale

0.571

High

162882

TERT
Telomerase reverse transcriptase

1

1

Small-scale

0.561

High

219687

VDR
Vitamin D3 receptor

1

20

Small-scale

0.561

High

219694

MK01
Mitogen-activated protein kinase 1

1

4

Small-scale

0.561

High

219673

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

13

High-throughput

0.554

High

219682

RB
Retinoblastoma-associated protein

1

9

High-throughput

0.554

High

219695

RBL1
Retinoblastoma-like protein 1

1

9

High-throughput

0.554

High

219699

CDC27
Cell division cycle protein 27 homolog

1

4

High-throughput

0.554

High

219742

ARHG2
Rho guanine nucleotide exchange factor 2

1

2

High-throughput

0.554

High

219746

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

1

High-throughput

0.554

High

219720

CDK6
Cyclin-dependent kinase 6

1

12

Small-scale

0.550

High

219689

BRAF
Serine/threonine-protein kinase B-raf

1

2

High-throughput

0.549

High

219679

ESR1
Estrogen receptor

1

20

Small-scale

0.546

High

219754

APC11
Anaphase-promoting complex subunit 11

1

0

Small-scale

0.537

High

219680

S100B
Protein S100-B

1

7

High-throughput

0.536

High

219722

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

3

High-throughput

0.536

High

219732

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

7

Small-scale

0.536

High

219759

TRRAP
Transformation/transcription domain-associated protein

1

9

High-throughput

0.536

High

219745

ERBIN
Erbin

1

5

Small-scale

0.527

High

219702

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

219753

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

13

Small-scale

0.515

High

219672

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.513

High

219677

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.513

High

219736

MK06
Mitogen-activated protein kinase 6

1

7

High-throughput

0.508

High

219712

NR1H2
Oxysterols receptor LXR-beta

1

20

High-throughput

0.481

High

219727

NR1H3
Oxysterols receptor LXR-alpha

1

20

High-throughput

0.481

High

219750

CDT1
DNA replication factor Cdt1

1

0

Small-scale

0.480

High

172290

XPO1
Exportin-1

1

10

High-throughput

0.479

High

219674

RAD17
Cell cycle checkpoint protein RAD17

1

2

Small-scale

0.479

High

219675

CHK2
Serine/threonine-protein kinase Chk2

1

13

Small-scale

0.479

High

219676

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.479

High

219678

MYC
Myc proto-oncogene protein

1

18

Small-scale

0.479

High

219684

IBP1
Insulin-like growth factor-binding protein 1

1

1

Small-scale

0.479

High

219686

PIM1
Serine/threonine-protein kinase pim-1

1

9

Small-scale

0.479

High

219688

PCNA
Proliferating cell nuclear antigen

1

1

Small-scale

0.479

High

219690

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

219692

PGFRA
Platelet-derived growth factor receptor alpha

1

5

Small-scale

0.479

High

219696

SHC1
SHC-transforming protein 1

1

7

Small-scale

0.479

High

219698

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

5

Small-scale

0.479

High

219705

BRCA1
Breast cancer type 1 susceptibility protein

1

1

Small-scale

0.479

High

219706

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

2

Small-scale

0.479

High

219707

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

7

Small-scale

0.479

High

219709

HCFC1
Host cell factor 1

1

7

Small-scale

0.479

High

219726

STK4
Serine/threonine-protein kinase 4

1

12

Small-scale

0.479

High

219730

CTBP1
C-terminal-binding protein 1

1

9

High-throughput

0.479

High

219735

SMAD1
Mothers against decapentaplegic homolog 1

1

19

Small-scale

0.479

High

219737

HIF1A
Hypoxia-inducible factor 1-alpha

1

19

Small-scale

0.479

High

219738

SIR6
NAD-dependent protein deacylase sirtuin-6

1

13

Small-scale

0.479

High

219739

BICD2
Protein bicaudal D homolog 2

1

5

High-throughput

0.479

High

219748

FACD2
Fanconi anemia group D2 protein

1

1

Small-scale

0.479

High

219751

HIPK2
Homeodomain-interacting protein kinase 2

1

13

Small-scale

0.479

High

219752

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.479

High

219755

NLK
Serine/threonine-protein kinase NLK

1

9

Small-scale

0.479

High

219756

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

Small-scale

0.479

High

219760

HCFC2
Host cell factor 2

1

6

Small-scale

0.479

High

219708

ARRB1
Beta-arrestin-1

1

0

Small-scale

0.458

High

219749

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.458

High

219758

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

219685

ANDR
Androgen receptor

1

20

Small-scale

0.445

High

219704

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.445

High

219710

IMA1
Importin subunit alpha-1

1

3

Small-scale

0.445

High

219717

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

3

Small-scale

0.445

High

219733

IMB1
Importin subunit beta-1

1

7

Small-scale

0.445

High

219683

CFAH
Complement factor H

1

4

Small-scale

0.437

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025