HitPredict

Interactor 1: DDX5 (P17844)
Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)
Gene: DDX5

Interactor 2: MED12 (Q93074)
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
Gene: MED12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27684187
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 614 Hs			1 2177
+	Hs
		134153 DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52		MED12_HUMAN (1-2177): 0: 2488: 100.00
+	Hs
		300524 DDX5_HUMAN (1-614): 0: 624: 100.00		NFAT5_HUMAN (1583-2168): 1.04e-12: 76.1: 12.29
+	Hs
		571535 DDX5_HUMAN (1-614): 0: 624: 100.00		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Hs
		300545 DDX17_HUMAN (30-612): 0: 534: 66.83		NFAT5_HUMAN (1583-2168): 1.04e-12: 76.1: 12.29
+	Hs
		1270758 DDX17_HUMAN (30-612): 0: 534: 66.83		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Dm
		580754 DDX17_DROME (2-481): 8.16e-150: 451: 60.87		Q9VTR6_DROME (1654-2117): 9.66e-11: 69.6: 12.16
+	Hs
		134144 DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Hs
		134182 DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52		ATX2_HUMAN (1645-2176): 2.64e-11: 71.5: 9.32