HitPredict

Interactor 1: PCNA (P17918)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: CDK4 (P30285)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12970760
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0000785 - chromatin GO:0005634 - nucleus
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 261 Mm			1 303
+	Bt
		1114085 PCNA_BOVIN (1-261): 8.08e-127: 362: 96.94		CDK2_BOVIN (3-301): 6.01e-145: 411: 43.23
+	Hs
		517061 PCNA_HUMAN (1-261): 2.24e-126: 360: 96.94		CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56
+	Mm
		572245 PCNA_MOUSE (1-261): 6.81e-128: 364: 100.00		CDK2_MOUSE (3-301): 8.13e-136: 389: 37.32
+	Hs
		414703 PCNA_HUMAN (1-261): 2.24e-126: 360: 96.94		CDK1_HUMAN (3-300): 8.51e-130: 372: 42.24
+	Bt
		1103882 PCNA_BOVIN (1-261): 8.08e-127: 362: 96.94		CDK4_BOVIN (1-297): 3.44e-127: 366: 95.62
+	Hs
		515316 PCNA_HUMAN (1-261): 2.24e-126: 360: 96.94		CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72
+	Hs
		517198 PCNA_HUMAN (1-261): 2.24e-126: 360: 96.94		CDK6_HUMAN (5-298): 2.33e-127: 367: 68.48
+	Bt
		970690 PCNA_BOVIN (1-261): 8.08e-127: 362: 96.94		CDK5_BOVIN (3-301): 2.02e-124: 358: 43.75
+	Hs
		517199 PCNA_HUMAN (1-261): 2.24e-126: 360: 96.94		CDK5_HUMAN (3-301): 1.7e-124: 358: 43.75