Protein: TBCD5
TBC1 domain family member 5

Gene: TBCD5, TBC1D5
Organism: Homo sapiens
Interactions: 91
UniProt ID: Q92609

Gene Ontology (top 5):
GO:0002092 - positive regulation of receptor internalization
GO:0005096 - GTPase activator activity
GO:0005776 - autophagosome
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1365456

VPS29
Vacuolar protein sorting-associated protein 29

10

2

Small-scale

0.759

High

901446

RAB7A
Ras-related protein Rab-7a

2

20

Small-scale

0.754

High

281767

VP26A
Vacuolar protein sorting-associated protein 26A

7

2

Small-scale

0.745

High

1365445

VPS35
Vacuolar protein sorting-associated protein 35

7

2

Small-scale

0.741

High

1194104

VP26B
Vacuolar protein sorting-associated protein 26B

6

2

Small-scale

0.732

High

952276

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

5

20

High-throughput

0.713

High

1365449

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

4

20

Small-scale

0.697

High

1365442

AP2M1
AP-2 complex subunit mu

3

1

Small-scale

0.663

High

1276257

ATG9A
Autophagy-related protein 9A

3

1

Small-scale

0.643

High

730110

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.635

High

126726

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

374105

RASN
GTPase NRas

1

20

High-throughput

0.618

High

375791

RASK
GTPase KRas

1

20

High-throughput

0.618

High

581207

RAC2
Ras-related C3 botulinum toxin substrate 2

1

12

High-throughput

0.618

High

630917

RAB4A
Ras-related protein Rab-4A

1

20

High-throughput

0.618

High

901978

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.618

High

945059

RAB25
Ras-related protein Rab-25

1

19

High-throughput

0.618

High

955436

CDC42
Cell division control protein 42 homolog

1

15

High-throughput

0.618

High

962334

RHOA
Transforming protein RhoA

1

15

High-throughput

0.618

High

976462

RB11A
Ras-related protein Rab-11A

1

18

High-throughput

0.618

High

988577

RAC1
Ras-related C3 botulinum toxin substrate 1

1

14

High-throughput

0.618

High

1015645

RHOG
Rho-related GTP-binding protein RhoG

1

12

High-throughput

0.618

High

1365453

RHOF
Rho-related GTP-binding protein RhoF

1

18

High-throughput

0.618

High

1365448

MLP3B
Microtubule-associated protein 1 light chain 3 beta

2

20

Small-scale

0.595

High

927461

ATX1
Ataxin-1

1

2

High-throughput

0.582

High

1365459

FBXL7
F-box/LRR-repeat protein 7

2

0

High-throughput

0.580

High

1332088

EIF1A
Probable RNA-binding protein EIF1AD

2

1

High-throughput

0.576

High

1365450

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

20

Small-scale

0.561

High

966693

1433G
14-3-3 protein gamma

1

20

High-throughput

0.554

High

1049632

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

1365446

CHIA
Acidic mammalian chitinase

2

1

High-throughput

0.553

High

1151802

RHOH
Rho-related GTP-binding protein RhoH

1

17

High-throughput

0.553

High

1365451

RHOJ
Rho-related GTP-binding protein RhoJ

1

16

High-throughput

0.553

High

935774

MFAP4
Microfibril-associated glycoprotein 4

2

1

High-throughput

0.549

High

691300

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

971840

1433E
14-3-3 protein epsilon

1

3

High-throughput

0.536

High

1326204

PNKD
Probable thioesterase PNKD

1

1

High-throughput

0.536

High

1365441

SPSB4
SPRY domain-containing SOCS box protein 4

1

8

High-throughput

0.536

High

466049

ANXA6
Annexin A6

2

1

High-throughput

0.533

High

843822

HD
Huntingtin

1

1

High-throughput

0.515

High

508363

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

1365460

DLEC1
Deleted in lung and esophageal cancer protein 1

1

0

High-throughput

0.493

High

173152

XPO1
Exportin-1

1

8

High-throughput

0.479

High

218564

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

412358

NTRK1
High affinity nerve growth factor receptor

1

16

High-throughput

0.479

High

651391

CBL
E3 ubiquitin-protein ligase CBL

1

1

High-throughput

0.479

High

714306

PML
Protein PML

1

2

High-throughput

0.479

High

730803

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

990562

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

1067554

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.479

High

1113877

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1144537

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

2

High-throughput

0.479

High

1295514

MIB1
E3 ubiquitin-protein ligase MIB1

1

2

High-throughput

0.479

High

1365440

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1365444

SNX27
Sorting nexin-27

1

9

High-throughput

0.479

High

1365447

TRIM6
Tripartite motif-containing protein 6

1

2

Small-scale

0.479

High

1365457

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

60801

CCD66
Coiled-coil domain-containing protein 66

1

0

High-throughput

0.458

High

390703

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

703007

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

959015

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

1225373

WAC2A
WASH complex subunit 2A

1

0

Small-scale

0.458

High

1289498

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1365443

VPS39
Vam6/Vps39-like protein

1

0

Small-scale

0.458

High

1365454

NGB
Neuroglobin

1

0

High-throughput

0.458

High

324266

FA13A
Protein FAM13A

1

2

Small-scale

0.457

High

1365455

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.457

High

279195

ULK1
Serine/threonine-protein kinase ULK1

1

2

Small-scale

0.445

High

1053043

VMAT2
Synaptic vesicular amine transporter

1

1

High-throughput

0.445

High

1239261

ARMC6
Armadillo repeat-containing protein 6

1

1

High-throughput

0.445

High

589298

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

696088

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

768785

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

1004910

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.437

High

1235307

STYK1
Tyrosine-protein kinase STYK1

1

16

High-throughput

0.437

High

1254875

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

1274114

OVCH1
Ovochymase-1

1

1

High-throughput

0.437

High

1293098

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

1326287

NIN
Ninein

1

3

High-throughput

0.437

High

1365452

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1365458

XPO7
Exportin-7

1

8

High-throughput

0.437

High

271554

ATG13
Autophagy-related protein 13

1

0

Small-scale

0.426

High

896425

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.426

High

1085190

WASC5
WASH complex subunit 5

1

0

Small-scale

0.426

High

1365439

LPAR1
Lysophosphatidic acid receptor 1

1

9

High-throughput

0.407

High

664393

ZBT25
Zinc finger and BTB domain-containing protein 25

2

0

High-throughput

0.316

High

1206672

LRC73
Leucine-rich repeat-containing protein 73

2

0

High-throughput

0.313

High

1311699

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

0

High-throughput

0.269

Low

1365438

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.249

Low

342633

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.232

Low

466946

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025