HitPredict

Interactor 1: PCNA (P17918)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: CDN1A (P39689)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein) (p21)
Gene: Cdkn1a

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	12970760, 24699724, 19416922
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0007507 - heart development GO:0016604 - nuclear body GO:0070557 - PCNA-p21 complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 261 Mm			1 159
+	Hs
		517110 PCNA_HUMAN (1-261): 2.24e-126: 360: 96.94		CDN1A_HUMAN (1-159): 4.51e-63: 192: 76.83
+	Hs
		758259 Q6FI35_HUMAN (1-261): 1.61e-125: 358: 96.55		CDN1A_HUMAN (1-159): 4.51e-63: 192: 76.83
+	Xl
		1161302 Q6PF20_XENLA (1-261): 1.56e-123: 353: 88.89		Q91646_XENLA (13-156): 2.88e-44: 146: 23.60
+	Hs
		517132 PCNA_HUMAN (1-261): 2.24e-126: 360: 96.94		CDN1C_HUMAN (7-129): 2.05e-36: 129: 30.47
+	Xl
		1137615 Q6PF20_XENLA (1-261): 1.56e-123: 353: 88.89		Q5V9L9_XENLA (12-156): 2.3e-38: 129: 34.00
+	Dm
		572181 PCNA_DROME (1-259): 1.98e-123: 353: 70.27		Q7JNL9_DROME (9-158): 2.63e-32: 116: 20.88