Protein: TRI35
E3 ubiquitin-protein ligase TRIM35 (EC 2.3.2.27) (Hemopoietic lineage switch protein 5)

Gene: TRI35, TRIM35
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q9UPQ4

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006915 - apoptotic process
GO:0008270 - zinc ion binding
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458958

TRI10
Tripartite motif-containing protein 10

6

16

High-throughput

0.944

High

957692

UBE2K
Ubiquitin-conjugating enzyme E2 K

4

20

High-throughput

0.892

High

1436479

AKTIP
AKT-interacting protein

2

20

High-throughput

0.811

High

906828

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

High-throughput

0.698

High

957245

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

High-throughput

0.698

High

982370

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.698

High

1383948

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1390318

TRI11
E3 ubiquitin-protein ligase TRIM11

1

16

High-throughput

0.698

High

1462531

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

161760

APAF
Apoptotic protease-activating factor 1

1

3

High-throughput

0.691

High

243302

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.665

High

1462100

UBQL1
Ubiquilin-1

1

9

High-throughput

0.665

High

1420578

TRIM5
Tripartite motif-containing protein 5

1

15

Small-scale

0.647

High

317039

MTA2
Metastasis-associated protein MTA2

2

3

High-throughput

0.628

High

833797

KDM5C
Lysine-specific demethylase 5C

2

6

High-throughput

0.628

High

1349278

WDR20
WD repeat-containing protein 20

2

6

High-throughput

0.628

High

1391429

OTUD5
OTU domain-containing protein 5

2

3

High-throughput

0.628

High

1459615

LIMD1
LIM domain-containing protein 1

2

7

High-throughput

0.628

High

1218771

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

1380888

TRI63
E3 ubiquitin-protein ligase TRIM63

1

19

High-throughput

0.621

High

1419333

TRI55
Tripartite motif-containing protein 55

1

18

High-throughput

0.621

High

868280

SYQ
Glutamine--tRNA ligase

2

2

High-throughput

0.615

High

922341

LIMK2
LIM domain kinase 2

2

1

High-throughput

0.611

High

225725

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

3

High-throughput

0.606

High

440244

LCK
Tyrosine-protein kinase Lck

2

8

High-throughput

0.606

High

682121

RBTN1
Rhombotin-1

2

4

High-throughput

0.606

High

994420

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

2

High-throughput

0.606

High

1086726

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

2

1

High-throughput

0.606

High

1225112

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

8

High-throughput

0.606

High

1289339

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

2

High-throughput

0.606

High

1290374

IGFN1
Immunoglobulin-like and fibronectin type III domain-containing protein 1

2

5

High-throughput

0.606

High

1290559

ZN410
Zinc finger protein 410

2

16

High-throughput

0.606

High

1331119

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

6

High-throughput

0.606

High

1332068

BANP
Protein BANP

2

1

High-throughput

0.606

High

1418683

PAR6B
Partitioning defective 6 homolog beta

2

4

High-throughput

0.606

High

718196

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

2

0

High-throughput

0.602

High

1451931

MKS1
Tectonic-like complex member MKS1

2

0

High-throughput

0.602

High

162385

PDCD5
Programmed cell death protein 5

2

0

High-throughput

0.580

High

296011

TPC6A
Trafficking protein particle complex subunit 6A

2

0

High-throughput

0.580

High

1161001

NRF1
Nuclear respiratory factor 1

2

0

High-throughput

0.580

High

1446166

CABP2
Calcium-binding protein 2

2

0

High-throughput

0.580

High

1462528

PHF24
PHD finger protein 24

2

0

High-throughput

0.580

High

1226754

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

2

1

High-throughput

0.574

High

573284

KPYM
Pyruvate kinase PKM

1

3

Small-scale

0.561

High

694417

CO8A1
Collagen alpha-1(VIII) chain

2

1

High-throughput

0.553

High

1155052

ADIPO
Adiponectin

2

3

High-throughput

0.553

High

1198287

FND3B
Fibronectin type III domain-containing protein 3B

2

3

High-throughput

0.553

High

1363741

SHC3
SHC-transforming protein 3

2

13

High-throughput

0.553

High

1399902

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

3

High-throughput

0.553

High

1430143

ENKD1
Enkurin domain-containing protein 1

2

1

High-throughput

0.553

High

1407502

TS101
Tumor susceptibility gene 101 protein

1

1

High-throughput

0.541

High

123934

MYO1F
Unconventional myosin-If

1

6

High-throughput

0.536

High

297713

PIAS1
E3 SUMO-protein ligase PIAS1

1

7

High-throughput

0.536

High

298635

RAD17
Cell cycle checkpoint protein RAD17

1

1

High-throughput

0.536

High

343658

OXSR1
Serine/threonine-protein kinase OSR1

1

9

High-throughput

0.536

High

624178

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

12

High-throughput

0.536

High

1029784

FOXK2
Forkhead box protein K2

1

3

High-throughput

0.536

High

1081662

HSP7E
Heat shock 70 kDa protein 14

1

9

High-throughput

0.536

High

1085121

KIF1A
Kinesin-like protein KIF1A

1

13

High-throughput

0.536

High

1247647

SAMD1
Sterile alpha motif domain-containing protein 1

1

2

High-throughput

0.536

High

1257964

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

14

High-throughput

0.536

High

1352194

SSH3
Protein phosphatase Slingshot homolog 3

1

3

High-throughput

0.536

High

1357896

CTF18
Chromosome transmission fidelity protein 18 homolog

1

2

High-throughput

0.536

High

1359649

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

2

High-throughput

0.536

High

1371781

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

7

High-throughput

0.536

High

1389425

RNF31
E3 ubiquitin-protein ligase RNF31

1

5

High-throughput

0.536

High

1406304

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

3

High-throughput

0.536

High

1446898

TF7L2
Transcription factor 7-like 2

1

6

High-throughput

0.536

High

1450774

KLH11
Kelch-like protein 11

1

4

High-throughput

0.536

High

1458339

SAE1
SUMO-activating enzyme subunit 1

1

2

High-throughput

0.536

High

1458828

ZMYM2
Zinc finger MYM-type protein 2

1

2

High-throughput

0.536

High

1462529

CD11A
Cyclin-dependent kinase 11A

1

6

High-throughput

0.536

High

1462533

MRCKB
Serine/threonine-protein kinase MRCK beta

1

8

High-throughput

0.536

High

75542

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

116824

I6L957
Heterogeneous nuclear ribonucleoproteins A2/B1

1

8

High-throughput

0.515

High

246186

KIF1B
Kinesin-like protein KIF1B

1

13

High-throughput

0.515

High

844102

HD
Huntingtin

1

2

High-throughput

0.515

High

1462532

RNF11
RING finger protein 11

1

4

High-throughput

0.515

High

888823

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

0

High-throughput

0.513

High

1152974

NAB2
NGFI-A-binding protein 2

1

0

High-throughput

0.513

High

1294741

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.513

High

1461400

TPC2L
Trafficking protein particle complex subunit 2-like protein

1

0

High-throughput

0.513

High

1462530

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.513

High

991123

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

High-throughput

0.489

High

1243257

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

1

High-throughput

0.489

High

1383713

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.489

High

1450075

ABCF3
ATP-binding cassette sub-family F member 3

1

2

High-throughput

0.489

High

288543

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

17

High-throughput

0.481

High

651027

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

6

High-throughput

0.481

High

1197596

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

9

High-throughput

0.481

High

1257899

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

9

High-throughput

0.481

High

1110894

IRF5
Interferon regulatory factor 5

1

11

Small-scale

0.479

High

1446860

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

2

Small-scale

0.479

High

650490

FGFR3
Fibroblast growth factor receptor 3

1

2

High-throughput

0.470

High

705611

GRN
Progranulin

1

2

High-throughput

0.470

High

1017684

PR20D
Proline-rich protein 20D

1

1

High-throughput

0.470

High

1279805

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

6

High-throughput

0.470

High

1462534

Q9Y649
GW128

1

1

High-throughput

0.470

High

1243302

MEAK7
MTOR-associated protein MEAK7

1

0

High-throughput

0.458

High

81641

B5MC51
Protein phosphatase 1 regulatory subunit 14

1

3

High-throughput

0.445

High

1017762

PR20A
Proline-rich protein 20A

1

1

High-throughput

0.439

High

1435248

ANTR1
Anthrax toxin receptor 1

1

1

Small-scale

0.439

High

221894

CHM2A
Charged multivesicular body protein 2a

2

0

High-throughput

0.328

High

1131938

GNMT
Glycine N-methyltransferase

2

0

High-throughput

0.316

High

1187178

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

0

High-throughput

0.279

Low

1324961

VW5B2
von Willebrand factor A domain-containing protein 5B2

1

0

High-throughput

0.279

Low

301764

WFS1
Wolframin

1

0

High-throughput

0.268

Low

1133933

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

0

High-throughput

0.268

Low

1191410

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025