HitPredict

Interactor 1: PRS6A (P17980)
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Gene: PSMC3

Interactor 2: E2AK4 (Q9P2K8)
eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein)
Gene: EIF2AK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 439 Hs			1 1649
+	Hs
		517882 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		HARS1_HUMAN (1054-1494): 3.42e-130: 417: 25.33
+	Hs
		874965 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		KS6A1_HUMAN (540-1048): 1.73e-89: 310: 15.24
+	Rn
		506750 PRS6A_RAT (1-439): 1.39e-135: 398: 99.32		KCC2A_RAT (11-208): 1.51e-29: 126: 12.56
+	Rn
		506709 PRS8_RAT (65-437): 1.93e-126: 373: 44.39		KCC2A_RAT (11-208): 1.51e-29: 126: 12.56
+	Hs
		907190 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		KCC2A_HUMAN (11-208): 1.52e-29: 126: 12.56
+	Sc
		548513 CDC48_YEAST (144-419): 9.98e-80: 265: 37.32		GCN2_YEAST (7-304): 1.24e-14: 82.1: 8.83