HitPredict

Interactor 1: TCPA (P17987)
T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1)
Gene: TCP1

Interactor 2: MK04 (P31152)
Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK)
Gene: MAPK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 556 Hs			1 587
+	Hs
		678541 TCPG_HUMAN (5-550): 0: 593: 33.03		MK04_HUMAN (1-587): 0: 530: 100.00
+	Hs
		678579 TCPH_HUMAN (1-545): 0: 566: 34.84		MK04_HUMAN (1-587): 0: 530: 100.00
+	Hs
		678540 TCPE_HUMAN (4-530): 0: 550: 31.96		MK04_HUMAN (1-587): 0: 530: 100.00
+	Hs
		573281 TCPA_HUMAN (1-556): 0: 630: 100.00		MK06_HUMAN (1-586): 3.18e-135: 412: 52.72
+	Hs
		573132 TCPA_HUMAN (1-556): 0: 630: 100.00		CDK2_HUMAN (17-318): 7.7e-138: 404: 31.27
+	Rn
		600336 TCPA_RAT (1-556): 0: 627: 97.66		MK03_RAT (11-361): 2.92e-135: 401: 39.83
+	Rn
		600455 TCPE_RAT (4-532): 0: 622: 31.84		MK03_RAT (11-361): 2.92e-135: 401: 39.83
+	Rn
		600476 TCPD_RAT (8-531): 0: 611: 32.02		MK03_RAT (11-361): 2.92e-135: 401: 39.83
+	Hs
		826682 TCPG_HUMAN (5-550): 0: 593: 33.03		MK06_HUMAN (1-586): 3.18e-135: 412: 52.72
+	Hs
		625228 TCPG_HUMAN (5-550): 0: 593: 33.03		CDK2_HUMAN (17-318): 7.7e-138: 404: 31.27
+	Rn
		600467 TCPG_RAT (5-550): 0: 594: 33.21		MK03_RAT (11-361): 2.92e-135: 401: 39.83
+	Hs
		1085489 TCPH_HUMAN (1-545): 0: 566: 34.84		MK06_HUMAN (1-586): 3.18e-135: 412: 52.72
+	Hs
		625579 TCPH_HUMAN (1-545): 0: 566: 34.84		CDK2_HUMAN (17-318): 7.7e-138: 404: 31.27
+	Hs
		821229 TCPE_HUMAN (4-530): 0: 550: 31.96		MK06_HUMAN (1-586): 3.18e-135: 412: 52.72
+	Hs
		625220 TCPE_HUMAN (4-530): 0: 550: 31.96		CDK2_HUMAN (17-318): 7.7e-138: 404: 31.27
+	Hs
		173861 TCPG_HUMAN (5-550): 0: 593: 33.03		MK13_HUMAN (13-328): 1.02e-60: 207: 37.81
+	Sc
		519911 TCPA_YEAST (4-542): 0: 558: 62.57		HOG1_YEAST (14-328): 2.36e-61: 211: 37.54
+	Sc
		691051 TCPG_YEAST (1-538): 0: 552: 29.20		HOG1_YEAST (14-328): 2.36e-61: 211: 37.54
+	Hs
		173858 TCPE_HUMAN (4-530): 0: 550: 31.96		MK13_HUMAN (13-328): 1.02e-60: 207: 37.81
+	Sc
		539365 TCPH_YEAST (10-531): 1.74e-87: 282: 35.10		KSS1_YEAST (8-333): 1.24e-60: 207: 35.65