Protein: KPYK
Pyruvate kinase (PK) (EC 2.7.1.40)

Gene: KPYK, Pyk
Organism: Drosophila melanogaster
Interactions: 59
UniProt ID: O62619

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004743 - pyruvate kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

264623

Q9VMW2
Reticulon-like protein

2

2

High-throughput

0.584

High

264622

Q9VMV9
Reticulon-like protein

2

1

High-throughput

0.570

High

264589

TUD
Protein tudor

2

0

Small-scale

0.559

High

264628

Q9VY42
Tyrosine aminotransferase

1

2

High-throughput

0.508

High

264629

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.508

High

118741

M9NFI9
Neurabin-1

1

2

High-throughput

0.484

High

262705

TENM
Teneurin-m

1

2

High-throughput

0.484

High

264606

Q8T0K8
GH25629p

1

1

High-throughput

0.481

High

264577

CRY1
Cryptochrome-1

1

1

High-throughput

0.479

High

264579

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

264582

KRAF1
Raf homolog serine/threonine-protein kinase Raf

1

3

High-throughput

0.479

High

264587

DDX6
ATP-dependent RNA helicase me31b

1

2

High-throughput

0.479

High

264594

SIMA
Protein similar

1

3

High-throughput

0.479

High

264595

Q24171
AT08303p

1

3

High-throughput

0.479

High

264596

DSOR1
Dual specificity mitogen-activated protein kinase kinase dSOR1

1

3

High-throughput

0.479

High

264600

Q7KN94
Electron transfer flavoprotein subunit alpha

1

1

High-throughput

0.479

High

264602

AKT1
RAC serine/threonine-protein kinase

1

1

High-throughput

0.479

High

264607

Q94533
Ribosomal protein S6 kinase

1

1

High-throughput

0.479

High

264608

LDH
L-lactate dehydrogenase

1

1

High-throughput

0.479

High

264615

Q9VEV3
Tetratricopeptide repeat protein 1

1

2

High-throughput

0.479

High

264616

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

High-throughput

0.479

High

264625

PYRG
CTP synthase

1

1

High-throughput

0.479

High

264576

AUB
Protein aubergine

1

0

Small-scale

0.458

High

264583

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.458

High

264590

CSW
Tyrosine-protein phosphatase corkscrew

1

0

High-throughput

0.458

High

264593

P91634
phosphatidylinositol 3-kinase

1

0

High-throughput

0.458

High

264609

Q95RF6
LD34461p

1

0

High-throughput

0.458

High

264610

FADD
Fas-associated death domain protein

1

0

High-throughput

0.458

High

264613

ATLAS
Atlastin

1

0

Small-scale

0.458

High

264619

ZUC
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

264626

Q9VV75
AT02348p

1

0

High-throughput

0.458

High

264580

NOTCH
Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein]

1

2

High-throughput

0.445

High

264586

SGG
Protein kinase shaggy

1

4

High-throughput

0.445

High

264614

INO80
Chromatin-remodeling ATPase INO80

1

1

High-throughput

0.445

High

264617

Q9VH81
protein-serine/threonine phosphatase

1

1

High-throughput

0.445

High

264620

Q9VLS7
LD21067p

1

2

High-throughput

0.445

High

264618

Q9VJW9
ADAM10 endopeptidase

1

1

High-throughput

0.442

High

264581

RAS1
Ras-like protein 1

1

2

High-throughput

0.437

High

264627

Q9VWJ6
FI03615p

1

1

High-throughput

0.437

High

264630

Q9W1H7
Putative homeodomain protein

1

3

High-throughput

0.437

High

264578

CHDM
Chromodomain-helicase-DNA-binding protein Mi-2 homolog

1

0

High-throughput

0.426

High

264584

ATNA
Sodium/potassium-transporting ATPase subunit alpha

1

0

High-throughput

0.426

High

264585

CATA
Catalase

1

0

High-throughput

0.426

High

264591

FAS2
Fasciclin-2

1

0

High-throughput

0.426

High

264592

CALM
Calmodulin

1

0

High-throughput

0.426

High

264603

Q8IRE7
PAN2-PAN3 deadenylation complex subunit PAN3

1

0

High-throughput

0.426

High

264611

FRIL
Ferritin light chain

1

0

High-throughput

0.426

High

264621

Q9VMH3
LD04103p

1

0

High-throughput

0.426

High

264598

Q6QU65
ADAM metalloprotease

1

1

High-throughput

0.407

High

264383

O62530
Adaptor protein complex 2, mu subunit, isoform A

1

0

High-throughput

0.265

Low

264604

Q8MT48
FXNA-like protease

1

0

High-throughput

0.265

Low

264612

Q9VBP2
GH01133p

1

0

High-throughput

0.265

Low

68866

MBD56
Methyl-CpG-binding domain protein 5/6 homolog sba

1

0

High-throughput

0.249

Low

264597

SRF
Serum response factor homolog

1

0

High-throughput

0.249

Low

264599

Q76NQ0
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.249

Low

264624

MELT
Protein melted

1

0

High-throughput

0.249

Low

264588

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.232

Low

264601

COPG
Coatomer subunit gamma

1

0

High-throughput

0.232

Low

264605

Q8STG9
DSec61alpha

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025