HitPredict

Interactor 1: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Interactor 2: VGFR3 (P35916)
Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
Gene: FLT4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 1363
+	Hs
		729647 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		VGFR2_HUMAN (1-1346): 0: 879: 42.21
+	Hs
		729643 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		VGFR2_HUMAN (1-1346): 0: 879: 42.21
+	Hs
		572587 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		VGFR1_HUMAN (19-1342): 0: 828: 38.63
+	Hs
		572628 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		VGFR1_HUMAN (19-1342): 0: 828: 38.63
+	Hs
		573629 PTN1_HUMAN (1-435): 0: 539: 100.00		EPHA5_HUMAN (373-1199): 1.28e-153: 493: 13.44
+	Hs
		452346 PTN1_HUMAN (1-435): 0: 539: 100.00		PGFRB_HUMAN (19-555): 1.14e-123: 413: 22.80
+	Hs
		434132 PTN1_HUMAN (1-435): 0: 539: 100.00		RET_HUMAN (801-1176): 1.25e-74: 273: 40.63
+	Hs
		452355 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		PGFRB_HUMAN (19-555): 1.14e-123: 413: 22.80
+	Hs
		452405 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		PGFRB_HUMAN (19-555): 1.14e-123: 413: 22.80
+	Hs
		452398 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		PGFRB_HUMAN (19-555): 1.14e-123: 413: 22.80
+	Hs
		452411 PTPRS_HUMAN (1-278): 3.66e-109: 355: 30.74		PGFRB_HUMAN (19-555): 1.14e-123: 413: 22.80
+	Hs
		169163 PTN1_HUMAN (1-435): 0: 539: 100.00		MUSK_HUMAN (2-152): 6.12e-16: 85.4: 13.25
+	Hs
		507839 PTN1_HUMAN (1-435): 0: 539: 100.00		FGFR1_HUMAN (2-160): 6.17e-14: 78.9: 11.93
+	Hs
		434120 PTPRF_HUMAN (19-278): 2.99e-105: 344: 30.94		RET_HUMAN (801-1176): 1.25e-74: 273: 40.63
+	Hs
		983479 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		PTK7_HUMAN (2-331): 1.72e-50: 197: 14.16
+	Hs
		499261 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		KIT_HUMAN (4-426): 3.17e-22: 106: 11.67
+	Hs
		499258 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		KIT_HUMAN (4-426): 3.17e-22: 106: 11.67
+	Hs
		607948 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		FGFR4_HUMAN (535-810): 1.64e-14: 80.8: 15.79
+	Hs
		601500 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		FGFR2_HUMAN (2-160): 1e-11: 71.9: 14.12
+	Hs
		507980 PTPRS_HUMAN (1-278): 3.66e-109: 355: 30.74		FGFR1_HUMAN (2-160): 6.17e-14: 78.9: 11.93