HitPredict

Interactor 1: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Interactor 2: CAV1 (Q03135)
Caveolin-1
Gene: CAV1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	12176037, 16388599
Identification Methods	affinity chromatography technology, phosphatase assay, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0019899 - enzyme binding GO:0019901 - protein kinase binding GO:0032991 - protein-containing complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 435 Hs			1 178
+	Hs
		489955 PTPRF_HUMAN (19-278): 2.99e-105: 344: 30.94		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Hs
		974776 PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Hs
		617104 PTPRG_HUMAN (342-435): 1.43e-21: 99.7: 13.46		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Mm
		719290 PTN11_MOUSE (39-274): 4.54e-49: 177: 38.80		CAV3_MOUSE (35-177): 1.81e-76: 227: 65.73
+	Hs
		665868 PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00