HitPredict

Interactor 1: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.80	0.721

Property	Details
Experiments	12237455, 35384245
Identification Methods	unspecified method, proximity labelling technology, peptide array, filter binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 839
+	Hs
		573718 PTN1_HUMAN (1-435): 0: 539: 100.00		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Hs
		384228 PTN1_HUMAN (1-435): 0: 539: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		507839 PTN1_HUMAN (1-435): 0: 539: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		384278 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		384743 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		434132 PTN1_HUMAN (1-435): 0: 539: 100.00		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		384692 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		573721 PTN1_HUMAN (1-435): 0: 539: 100.00		DDR2_HUMAN (527-824): 2.05e-70: 250: 43.30
+	Hs
		573663 PTN1_HUMAN (1-435): 0: 539: 100.00		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		411291 PTN1_HUMAN (1-435): 0: 539: 100.00		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435529 PTN1_HUMAN (1-435): 0: 539: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		537715 PTN1_HUMAN (1-435): 0: 539: 100.00		INSRR_HUMAN (513-820): 1.33e-62: 231: 40.84
+	Hs
		573975 PTN1_HUMAN (1-435): 0: 539: 100.00		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03
+	Hs
		411290 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		169163 PTN1_HUMAN (1-435): 0: 539: 100.00		MUSK_HUMAN (209-391): 1.75e-22: 105: 24.60
+	Hs
		411297 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		411369 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		616937 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03
+	Hs
		411361 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		1020121 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03