HitPredict

Interactor 1: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.792

Property	Details
Experiments	25288805, 12237455
Identification Methods	pull down, unspecified method, peptide array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005769 - early endosome GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 822
+	Hs
		573716 PTN1_HUMAN (1-435): 0: 539: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		384228 PTN1_HUMAN (1-435): 0: 539: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		507839 PTN1_HUMAN (1-435): 0: 539: 100.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		434132 PTN1_HUMAN (1-435): 0: 539: 100.00		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		384278 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		384743 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		384692 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		573721 PTN1_HUMAN (1-435): 0: 539: 100.00		DDR2_HUMAN (491-807): 5.97e-75: 263: 43.40
+	Hs
		435529 PTN1_HUMAN (1-435): 0: 539: 100.00		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		411291 PTN1_HUMAN (1-435): 0: 539: 100.00		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		573663 PTN1_HUMAN (1-435): 0: 539: 100.00		ROR2_HUMAN (530-808): 1.44e-69: 249: 44.52
+	Hs
		537715 PTN1_HUMAN (1-435): 0: 539: 100.00		INSRR_HUMAN (513-814): 4.91e-68: 247: 42.43
+	Hs
		573975 PTN1_HUMAN (1-435): 0: 539: 100.00		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44
+	Hs
		573585 PTN1_HUMAN (1-435): 0: 539: 100.00		LTK_HUMAN (506-808): 6.29e-61: 223: 38.07
+	Hs
		411290 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		411297 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		411369 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		616937 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44
+	Hs
		169163 PTN1_HUMAN (1-435): 0: 539: 100.00		MUSK_HUMAN (193-374): 7.66e-18: 90.5: 22.92
+	Hs
		1020121 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44