Protein: RN115
E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rab7-interacting RING finger protein) (Rabring 7) (Zinc finger protein 364)

Gene: RN115, RNF115
Organism: Homo sapiens
Interactions: 140
UniProt ID: Q9Y4L5

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

982377

UB2D2
Ubiquitin-conjugating enzyme E2 D2

7

20

Small-scale

0.964

High

906835

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

20

High-throughput

0.932

High

1490989

UB2D4
Ubiquitin-conjugating enzyme E2 D4

5

20

High-throughput

0.932

High

957254

UB2D3
Ubiquitin-conjugating enzyme E2 D3

4

20

High-throughput

0.911

High

1381223

UB2E3
Ubiquitin-conjugating enzyme E2 E3

3

20

High-throughput

0.861

High

508893

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

18

Small-scale

0.850

High

1383949

UBE2W
Ubiquitin-conjugating enzyme E2 W

2

20

High-throughput

0.817

High

931626

RD23A
UV excision repair protein RAD23 homolog A

2

18

Small-scale

0.793

High

1397307

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

20

High-throughput

0.783

High

1491442

RN115
E3 ubiquitin-protein ligase RNF115

2

16

Small-scale

0.778

High

993831

UBC9
SUMO-conjugating enzyme UBC9

2

20

Small-scale

0.767

High

909417

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

1139166

DAZP2
DAZ-associated protein 2

3

1

High-throughput

0.672

High

679417

DNJB2
DnaJ homolog subfamily B member 2

3

5

High-throughput

0.650

High

957875

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

901711

RAB7A
Ras-related protein Rab-7a

2

20

Small-scale

0.624

High

425688

ISG15
Ubiquitin-like protein ISG15

1

18

Small-scale

0.618

High

1291021

TAXB1
Tax1-binding protein 1

2

7

High-throughput

0.612

High

343119

HERC2
E3 ubiquitin-protein ligase HERC2

2

9

High-throughput

0.611

High

935345

TERA
Transitional endoplasmic reticulum ATPase

2

5

Small-scale

0.606

High

665020

ERD21
ER lumen protein-retaining receptor 1

2

0

High-throughput

0.602

High

730396

1433B
14-3-3 protein beta/alpha

2

13

Small-scale

0.584

High

981388

RAB1A
Ras-related protein Rab-1A

1

17

Small-scale

0.578

High

857001

BAG6
Large proline-rich protein BAG6

1

13

Small-scale

0.575

High

163399

GBRD
Gamma-aminobutyric acid receptor subunit delta

2

2

High-throughput

0.574

High

730988

1433S
14-3-3 protein sigma

1

13

Small-scale

0.573

High

179750

MDM4
Protein Mdm4

1

2

High-throughput

0.573

High

364083

EGFR
Epidermal growth factor receptor

1

5

Small-scale

0.561

High

373605

MYC
Myc proto-oncogene protein

1

1

Small-scale

0.561

High

1292895

STING
Stimulator of interferon genes protein

1

2

Small-scale

0.561

High

1371579

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

8

Small-scale

0.561

High

1383220

RAB7B
Ras-related protein Rab-7b

1

20

Small-scale

0.561

High

1404706

PFD5
Prefoldin subunit 5

1

0

Small-scale

0.537

High

248806

PEPL
Periplakin

1

5

High-throughput

0.536

High

276646

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

3

High-throughput

0.536

High

289295

SPB7
Serpin B7

1

7

High-throughput

0.536

High

369525

AACT
Alpha-1-antichymotrypsin

1

7

High-throughput

0.536

High

424571

PAI2
Plasminogen activator inhibitor 2

1

7

High-throughput

0.536

High

457940

INVO
Involucrin

1

1

High-throughput

0.536

High

483989

HMOX1
Heme oxygenase 1

1

3

High-throughput

0.536

High

578738

GLNA
Glutamine synthetase

1

1

High-throughput

0.536

High

582647

PPAP
Prostatic acid phosphatase

1

1

High-throughput

0.536

High

615253

IL1RA
Interleukin-1 receptor antagonist protein

1

2

High-throughput

0.536

High

652444

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.536

High

692849

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.536

High

713487

SPB3
Serpin B3

1

6

High-throughput

0.536

High

748669

DSG3
Desmoglein-3

1

4

High-throughput

0.536

High

827974

STAT3
Signal transducer and activator of transcription 3

1

1

High-throughput

0.536

High

874892

SPB4
Serpin B4

1

6

High-throughput

0.536

High

931318

AT12A
Potassium-transporting ATPase alpha chain 2

1

4

High-throughput

0.536

High

1107514

BIRC2
Baculoviral IAP repeat-containing protein 2

1

4

High-throughput

0.536

High

1138199

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.536

High

1286363

S1A7A
Protein S100-A7A

1

1

High-throughput

0.536

High

1292438

SPA9
Serpin A9

1

7

High-throughput

0.536

High

1294076

PA24D
Cytosolic phospholipase A2 delta

1

7

High-throughput

0.536

High

1369029

EVPL
Envoplakin

1

4

High-throughput

0.536

High

1369724

KLK6
Kallikrein-6

1

2

High-throughput

0.536

High

1418852

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

4

High-throughput

0.536

High

1453261

IL36G
Interleukin-36 gamma

1

2

High-throughput

0.536

High

1453608

CALL5
Calmodulin-like protein 5

1

3

High-throughput

0.536

High

1458401

I36RA
Interleukin-36 receptor antagonist protein

1

2

High-throughput

0.536

High

1460507

SPB13
Serpin B13

1

6

High-throughput

0.536

High

1460555

NAGK
N-acetyl-D-glucosamine kinase

1

2

High-throughput

0.536

High

126267

ST2B1
Sulfotransferase 2B1

1

0

High-throughput

0.513

High

333883

PAPS2
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

1

0

High-throughput

0.513

High

568993

ANXA8
Annexin A8

1

0

High-throughput

0.513

High

627179

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.513

High

839648

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.513

High

868803

LEG7
Galectin-7

1

0

High-throughput

0.513

High

890787

PSN2
Presenilin-2

1

0

High-throughput

0.513

High

1031139

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

0

High-throughput

0.513

High

1070185

NTCP7
Sodium/bile acid cotransporter 7

1

0

High-throughput

0.513

High

1150583

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

1292592

FCSD1
F-BAR and double SH3 domains protein 1

1

0

High-throughput

0.513

High

1369516

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1400670

GSDMA
Gasdermin-A

1

0

High-throughput

0.513

High

1430269

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.513

High

1462133

NDRG2
Protein NDRG2

1

0

High-throughput

0.513

High

1278157

MAVS
Mitochondrial antiviral-signaling protein

1

3

Small-scale

0.512

High

423525

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

683544

IKBA
NF-kappa-B inhibitor alpha

1

2

Small-scale

0.501

High

728499

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.501

High

1028463

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

High-throughput

0.501

High

142168

NPT3
Sodium-dependent phosphate transport protein 3

1

2

High-throughput

0.489

High

380387

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

6

High-throughput

0.489

High

1009752

NGAL
Neutrophil gelatinase-associated lipocalin

1

1

High-throughput

0.489

High

1060035

SCN1B
Sodium channel regulatory subunit beta-1

1

1

High-throughput

0.489

High

1254055

R9BP
Regulator of G-protein signaling 9-binding protein

1

1

High-throughput

0.489

High

1316019

NRSN1
Neurensin-1

1

2

High-throughput

0.489

High

375041

RASH
GTPase HRas

1

18

Small-scale

0.481

High

1143048

CDK10
Cyclin-dependent kinase 10

1

3

Small-scale

0.481

High

1323657

DOCK4
Dedicator of cytokinesis protein 4

1

1

Small-scale

0.481

High

126349

TLR4
Toll-like receptor 4

1

5

Small-scale

0.479

High

191250

TLR3
Toll-like receptor 3

1

5

Small-scale

0.479

High

573736

ENPL
Endoplasmin

1

4

Small-scale

0.479

High

631592

RAB5A
Ras-related protein Rab-5A

1

17

Small-scale

0.479

High

691581

1433T
14-3-3 protein theta

1

13

Small-scale

0.479

High

902237

RAB13
Ras-related protein Rab-13

1

15

Small-scale

0.479

High

967070

1433G
14-3-3 protein gamma

1

13

Small-scale

0.479

High

972177

1433E
14-3-3 protein epsilon

1

2

Small-scale

0.479

High

990918

1433Z
14-3-3 protein zeta/delta

1

13

Small-scale

0.479

High

1049948

1433F
14-3-3 protein eta

1

13

Small-scale

0.479

High

1056007

RAD51
DNA repair protein RAD51 homolog 1

1

1

Small-scale

0.479

High

1280634

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

High-throughput

0.479

High

1448085

TLR9
Toll-like receptor 9

1

4

Small-scale

0.479

High

1452655

TLR7
Toll-like receptor 7

1

5

Small-scale

0.479

High

1460331

XPO7
Exportin-7

1

3

High-throughput

0.479

High

1461021

FBW1B
F-box/WD repeat-containing protein 11

1

2

High-throughput

0.479

High

370050

CYTC
Cystatin-C

1

0

Small-scale

0.460

High

928373

ATN1
Atrophin-1

1

0

Small-scale

0.460

High

1037707

RL18A
Large ribosomal subunit protein eL20

1

0

Small-scale

0.460

High

591903

H2AX
Histone H2AX

1

0

Small-scale

0.458

High

1431026

UN93B
Protein unc-93 homolog B1

1

0

Small-scale

0.458

High

389905

TTHY
Transthyretin

1

1

Small-scale

0.457

High

1239576

ZNT6
Zinc transporter 6

1

4

High-throughput

0.445

High

1310989

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

4

High-throughput

0.445

High

1337284

GMCL2
Germ cell-less protein-like 2

1

2

High-throughput

0.445

High

1381044

S35B4
Nucleotide sugar transporter SLC35B4

1

2

High-throughput

0.445

High

1460539

RABX5
Rab5 GDP/GTP exchange factor

1

1

High-throughput

0.445

High

935822

MFAP4
Microfibril-associated glycoprotein 4

1

1

Small-scale

0.439

High

75746

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

2

High-throughput

0.437

High

1249362

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

49211

IGLC7
Immunoglobulin lambda constant 7

1

10

High-throughput

0.407

High

69572

A2ML1
Alpha-2-macroglobulin-like protein 1

1

2

High-throughput

0.407

High

379324

IGHG1
Immunoglobulin heavy constant gamma 1

1

4

High-throughput

0.407

High

379414

IGHG2
Immunoglobulin heavy constant gamma 2

1

8

High-throughput

0.407

High

379445

IGHG3
Immunoglobulin heavy constant gamma 3

1

8

High-throughput

0.407

High

379480

IGHG4
Immunoglobulin heavy constant gamma 4

1

4

High-throughput

0.407

High

1273837

NIPA1
Magnesium transporter NIPA1

1

2

High-throughput

0.407

High

1398031

MF14A
Hippocampus abundant transcript 1 protein

1

3

High-throughput

0.407

High

1419174

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

2

High-throughput

0.407

High

261676

CATL2
Cathepsin L2

1

0

High-throughput

0.279

Low

1153707

CH3L2
Chitinase-3-like protein 2

1

0

High-throughput

0.279

Low

1253052

ACP7
Acid phosphatase type 7

1

0

High-throughput

0.279

Low

1359109

TMM40
Transmembrane protein 40

1

0

High-throughput

0.279

Low

1491423

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

0

High-throughput

0.279

Low

834933

FOLR3
Folate receptor gamma

1

0

Small-scale

0.251

Low

1155211

EREP1
Endosomal transmembrane epsin interactor 1

1

0

Small-scale

0.238

Low

1206693

LRC73
Leucine-rich repeat-containing protein 73

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025