Protein: HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1 (EC 2.3.2.27) (HMG-CoA reductase degradation protein 1) (RING-type E3 ubiquitin transferase HRD1)

Gene: HRD1
Organism: Saccharomyces cerevisiae S288C
Interactions: 73
UniProt ID: Q08109

Gene Ontology (top 5):
GO:0000836 - Hrd1p ubiquitin ligase complex
GO:0000838 - Hrd1p ubiquitin ligase ERAD-M complex
GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1061658

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

16

16

Small-scale

0.986

High

1035150

UBC7
Ubiquitin-conjugating enzyme E2 7

16

20

Small-scale

0.986

High

585735

UBC4
Ubiquitin-conjugating enzyme E2 4

2

20

Small-scale

0.778

High

1052331

HRD3
ERAD-associated E3 ubiquitin-protein ligase component HRD3

14

5

Small-scale

0.762

High

509741

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

3

18

Small-scale

0.756

High

680114

CDC48
Cell division control protein 48

10

12

Small-scale

0.756

High

554452

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

6

4

Small-scale

0.739

High

640565

UBC1
Ubiquitin-conjugating enzyme E2 1

1

20

Small-scale

0.724

High

1046149

UBX2
UBX domain-containing protein 2

8

0

Small-scale

0.720

High

1043823

USA1
U1 SNP1-associating protein 1

8

0

Small-scale

0.720

High

1061661

OS9
Protein OS-9 homolog

7

0

Small-scale

0.713

High

797818

DER1
Degradation in the endoplasmic reticulum protein 1

6

0

Small-scale

0.702

High

366064

CBPY
Carboxypeptidase Y

6

0

Small-scale

0.696

High

754453

NPL4
Nuclear protein localization protein 4

3

1

Small-scale

0.664

High

750601

UBC6
Ubiquitin-conjugating enzyme E2 6

1

20

Small-scale

0.647

High

916751

UFD1
Ubiquitin fusion degradation protein 1

2

3

Small-scale

0.624

High

1061660

DFM1
DER1-like family member protein 1

2

8

Small-scale

0.611

High

525349

HSP71
Heat shock protein SSA1

3

14

High-throughput

0.569

High

849723

OTU1
Ubiquitin thioesterase OTU1

1

3

Small-scale

0.550

High

393431

HSP82
ATP-dependent molecular chaperone HSP82

2

12

High-throughput

0.537

High

580169

HSC82
ATP-dependent molecular chaperone HSC82

2

12

High-throughput

0.537

High

727364

HS104
Heat shock protein 104

2

3

High-throughput

0.537

High

554379

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

4

Small-scale

0.536

High

527844

HSP72
Heat shock protein SSA2

2

14

High-throughput

0.521

High

438778

SC160
Protein SCP160

1

5

High-throughput

0.515

High

828279

SYA
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.515

High

432369

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.493

High

742964

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.489

High

799715

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

1

0

Small-scale

0.480

High

597288

BIP
Endoplasmic reticulum chaperone BiP

1

12

Small-scale

0.479

High

636350

ACO1
Acyl-CoA desaturase 1

1

1

Small-scale

0.479

High

726121

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

3

Small-scale

0.479

High

751013

PRS7
26S proteasome regulatory subunit 7 homolog

1

15

Small-scale

0.479

High

754727

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

3

Small-scale

0.479

High

359074

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

6

High-throughput

0.470

High

359536

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

6

High-throughput

0.470

High

471442

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

1

High-throughput

0.470

High

518407

IF4A
ATP-dependent RNA helicase eIF4A

1

6

High-throughput

0.470

High

585656

STI1
Heat shock protein STI1

1

6

High-throughput

0.470

High

597566

EF3A
Elongation factor 3A

1

1

High-throughput

0.470

High

598924

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

3

High-throughput

0.470

High

687619

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.470

High

710016

BMH1
Protein BMH1

1

8

High-throughput

0.470

High

734217

EF2
Elongation factor 2

1

2

High-throughput

0.470

High

739797

SPT16
FACT complex subunit SPT16

1

1

High-throughput

0.470

High

743360

FIMB
Fimbrin

1

3

High-throughput

0.470

High

915254

ACS2
Acetyl-coenzyme A synthetase 2

1

3

High-throughput

0.470

High

1046946

POB3
FACT complex subunit POB3

1

2

High-throughput

0.470

High

1059372

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.470

High

668302

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

Small-scale

0.458

High

751128

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

1

Small-scale

0.457

High

624816

PMA2
Plasma membrane ATPase 2

1

5

High-throughput

0.437

High

481787

HSP73
Heat shock protein SSA3

1

14

High-throughput

0.407

High

546519

SSB1
Ribosome-associated molecular chaperone SSB1

1

14

High-throughput

0.407

High

671184

SIS1
Protein SIS1

1

6

High-throughput

0.407

High

742535

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.407

High

752813

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.407

High

816439

HSP7E
Heat shock protein SSC3, mitochondrial

1

14

High-throughput

0.407

High

819966

SSB2
Ribosome-associated molecular chaperone SSB2

1

14

High-throughput

0.407

High

1052941

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

18

High-throughput

0.407

High

366730

HIS2
Histidine biosynthesis trifunctional protein [Includes: Phosphoribosyl-AMP cyclohydrolase

1

0

High-throughput

0.269

Low

454132

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.269

Low

585151

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.269

Low

585515

KCY
Uridylate kinase

1

0

High-throughput

0.269

Low

591961

THRC
Threonine synthase

1

0

High-throughput

0.269

Low

725900

CYS3
Cystathionine gamma-lyase

1

0

High-throughput

0.269

Low

804129

RPP1
Ribonuclease P/MRP protein subunit RPP1

1

0

High-throughput

0.269

Low

850676

DUG1
Cys-Gly metallodipeptidase DUG1

1

0

High-throughput

0.269

Low

925495

IDHH
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.269

Low

1043358

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.269

Low

1061659

SPEE
Spermidine synthase SPE3

1

0

High-throughput

0.269

Low

1059785

HBT1
Protein HBT1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025