HitPredict

Interactor 1: ADA2B (P18089)
Alpha-2B adrenergic receptor (Alpha-2 adrenergic receptor subtype C2) (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR)
Gene: ADRA2B

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25517094
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 450 Hs			1 352
+	Hs
		574791 ADA2B_HUMAN (1-450): 2.18e-109: 332: 100.00		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		445810 ADA2A_HUMAN (5-448): 2.65e-87: 275: 48.10		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		445811 ADA2A_HUMAN (5-448): 2.65e-87: 275: 48.10		SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08
+	Mm
		897202 DRD2_MOUSE (15-443): 4.67e-82: 261: 27.91		SH3G2_MOUSE (1-352): 3.65e-95: 288: 98.86
+	Hs
		436885 ACM2_HUMAN (4-446): 6.54e-79: 254: 19.87		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		436948 ACM4_HUMAN (13-446): 1.04e-77: 251: 20.85		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		723002 HRH1_HUMAN (2-442): 1.53e-77: 251: 21.55		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		445809 ADA2A_HUMAN (5-448): 2.65e-87: 275: 48.10		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		436949 ACM4_HUMAN (13-446): 1.04e-77: 251: 20.85		SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08
+	Hs
		723003 HRH1_HUMAN (2-442): 1.53e-77: 251: 21.55		SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08
+	Hs
		723748 DRD3_HUMAN (12-443): 1.23e-69: 228: 29.13		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		436884 ACM2_HUMAN (4-446): 6.54e-79: 254: 19.87		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		436947 ACM4_HUMAN (13-446): 1.04e-77: 251: 20.85		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		723001 HRH1_HUMAN (2-442): 1.53e-77: 251: 21.55		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		723749 DRD3_HUMAN (12-443): 1.23e-69: 228: 29.13		SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08
+	Hs
		723747 DRD3_HUMAN (12-443): 1.23e-69: 228: 29.13		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		1307428 HRH3_HUMAN (26-445): 9.18e-62: 208: 25.47		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Mm
		897204 DRD2_MOUSE (15-443): 4.67e-82: 261: 27.91		SH3K1_MOUSE (280-347): 3.72e-10: 63.2: 44.00
+	Hs
		723735 DRD3_HUMAN (12-443): 1.23e-69: 228: 29.13		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		602194 DRD4_HUMAN (20-443): 4.96e-64: 214: 29.04		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10