Protein: UB2D4
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)

Gene: UB2D4, UBE2D4
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q9Y2X8

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1490987

RNF11
RING finger protein 11

7

20

High-throughput

0.965

High

1460665

TRIM1
Probable E3 ubiquitin-protein ligase MID2

7

20

Small-scale

0.964

High

1384580

RNF25
E3 ubiquitin-protein ligase RNF25

5

14

High-throughput

0.935

High

1490989

RN115
E3 ubiquitin-protein ligase RNF115

5

20

High-throughput

0.932

High

647684

UBA1
Ubiquitin-like modifier-activating enzyme 1

5

20

Small-scale

0.917

High

1408213

RNF5
E3 ubiquitin-protein ligase RNF5

4

20

High-throughput

0.911

High

1336243

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

4

20

High-throughput

0.904

High

1458705

RNF14
E3 ubiquitin-protein ligase RNF14

3

20

High-throughput

0.873

High

1414950

RN126
E3 ubiquitin-protein ligase RNF126

3

20

High-throughput

0.862

High

1055875

RING1
E3 ubiquitin-protein ligase RING1

3

20

High-throughput

0.861

High

1331925

DTX3
Probable E3 ubiquitin-protein ligase DTX3

3

20

High-throughput

0.861

High

1382356

RN166
E3 ubiquitin-protein ligase RNF166

3

20

High-throughput

0.861

High

1391936

RN185
E3 ubiquitin-protein ligase RNF185

3

20

High-throughput

0.861

High

1404857

RING2
E3 ubiquitin-protein ligase RING2

3

20

High-throughput

0.861

High

1420192

TRIM8
E3 ubiquitin-protein ligase TRIM8

3

20

High-throughput

0.861

High

1453960

RN181
E3 ubiquitin-protein ligase RNF181

3

20

High-throughput

0.861

High

1005268

RNF4
E3 ubiquitin-protein ligase RNF4

3

20

Small-scale

0.852

High

1391085

OTUB1
Ubiquitin thioesterase OTUB1

5

10

High-throughput

0.833

High

1328538

RNF10
E3 ubiquitin-protein ligase RNF10

2

20

High-throughput

0.817

High

1243733

RFWD3
E3 ubiquitin-protein ligase RFWD3

2

20

High-throughput

0.815

High

1252791

RN111
E3 ubiquitin-protein ligase Arkadia

2

20

High-throughput

0.815

High

1461266

AMFR
E3 ubiquitin-protein ligase AMFR

2

20

High-throughput

0.815

High

186599

TRI18
E3 ubiquitin-protein ligase Midline-1

4

20

Small-scale

0.801

High

1381412

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

2

20

Small-scale

0.800

High

1420598

TRIM2
Tripartite motif-containing protein 2

2

20

Small-scale

0.800

High

1435277

RN167
E3 ubiquitin-protein ligase RNF167

2

20

Small-scale

0.800

High

1437503

UBTD1
Ubiquitin domain-containing protein 1

4

5

Small-scale

0.789

High

1348586

LNX1
E3 ubiquitin-protein ligase LNX

2

4

High-throughput

0.783

High

1459810

MKRN1
E3 ubiquitin-protein ligase makorin-1

2

14

High-throughput

0.783

High

243350

PRKN
E3 ubiquitin-protein ligase parkin

2

20

Small-scale

0.768

High

508868

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

Small-scale

0.768

High

279076

TRIM3
Tripartite motif-containing protein 3

2

20

Small-scale

0.767

High

1294335

TRI50
E3 ubiquitin-protein ligase TRIM50

3

20

Small-scale

0.755

High

1289342

DTX2
Probable E3 ubiquitin-protein ligase DTX2

6

20

High-throughput

0.741

High

1439327

TRI39
E3 ubiquitin-protein ligase TRIM39

5

20

High-throughput

0.726

High

1357063

UBTD2
Ubiquitin domain-containing protein 2

2

5

High-throughput

0.700

High

1419272

TRI54
Tripartite motif-containing protein 54

2

20

High-throughput

0.700

High

128519

RN103
E3 ubiquitin-protein ligase RNF103

1

20

High-throughput

0.698

High

208592

PJA2
E3 ubiquitin-protein ligase Praja-2

1

20

High-throughput

0.698

High

220521

RNF13
E3 ubiquitin-protein ligase RNF13

1

20

High-throughput

0.698

High

244512

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

6

High-throughput

0.698

High

322562

RNF37
RING finger protein 37

1

5

High-throughput

0.698

High

335203

ARI2
E3 ubiquitin-protein ligase ARIH2

1

20

High-throughput

0.698

High

340598

CNOT4
CCR4-NOT transcription complex subunit 4

1

11

High-throughput

0.698

High

1022814

XIAP
E3 ubiquitin-protein ligase XIAP

1

20

High-throughput

0.698

High

1093742

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

14

High-throughput

0.698

High

1121158

UBE4A
Ubiquitin conjugation factor E4 A

1

20

High-throughput

0.698

High

1125266

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

High-throughput

0.698

High

1229146

RNF43
E3 ubiquitin-protein ligase RNF43

1

20

High-throughput

0.698

High

1246181

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

10

High-throughput

0.698

High

1248454

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

6

High-throughput

0.698

High

1254114

ARK2C
E3 ubiquitin-protein ligase ARK2C

1

20

High-throughput

0.698

High

1294294

GOLI
E3 ubiquitin-protein ligase RNF130

1

20

High-throughput

0.698

High

1294597

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

20

High-throughput

0.698

High

1295603

MIB1
E3 ubiquitin-protein ligase MIB1

1

10

High-throughput

0.698

High

1350958

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

20

High-throughput

0.698

High

1357999

RN138
E3 ubiquitin-protein ligase RNF138

1

20

High-throughput

0.698

High

1359375

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

20

High-throughput

0.698

High

1389452

CHFR
E3 ubiquitin-protein ligase CHFR

1

20

High-throughput

0.698

High

1389548

RN125
E3 ubiquitin-protein ligase RNF125

1

20

High-throughput

0.698

High

1391448

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

6

High-throughput

0.698

High

1399328

BIRC8
Baculoviral IAP repeat-containing protein 8

1

20

High-throughput

0.698

High

1399872

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

5

High-throughput

0.698

High

1399980

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

8

High-throughput

0.698

High

1418847

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

20

High-throughput

0.698

High

1420579

TRIM5
Tripartite motif-containing protein 5

1

20

High-throughput

0.698

High

1429974

RNF38
E3 ubiquitin-protein ligase RNF38

1

20

High-throughput

0.698

High

1449085

TOPRS
E3 ubiquitin-protein ligase Topors

1

6

High-throughput

0.698

High

1450919

RNF12
E3 ubiquitin-protein ligase RLIM

1

20

High-throughput

0.698

High

1458374

RBX2
RING-box protein 2

1

20

High-throughput

0.698

High

1461632

RN150
RING finger protein 150

1

20

High-throughput

0.698

High

1462531

TRI35
E3 ubiquitin-protein ligase TRIM35

1

20

High-throughput

0.698

High

1490988

TRAF6
TNF receptor-associated factor 6

1

20

High-throughput

0.698

High

1490991

TRI17
E3 ubiquitin-protein ligase TRIM17

1

20

High-throughput

0.698

High

507431

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

High-throughput

0.691

High

957247

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

17

High-throughput

0.691

High

1129398

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

20

High-throughput

0.691

High

1461718

HECD1
E3 ubiquitin-protein ligase HECTD1

1

20

High-throughput

0.691

High

1429258

MKRN2
E3 ubiquitin-protein ligase makorin-2

3

14

High-throughput

0.675

High

1417857

RNF26
E3 ubiquitin-protein ligase RNF26

1

20

High-throughput

0.656

High

1490990

RN114
E3 ubiquitin-protein ligase RNF114

1

20

High-throughput

0.656

High

132395

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

20

Small-scale

0.647

High

326110

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.647

High

783461

TRI23
E3 ubiquitin-protein ligase TRIM23

1

7

Small-scale

0.647

High

984030

RBX1
E3 ubiquitin-protein ligase RBX1

1

20

Small-scale

0.647

High

1028459

MDM2
E3 ubiquitin-protein ligase Mdm2

1

14

Small-scale

0.647

High

1361437

MYLIP
E3 ubiquitin-protein ligase MYLIP

1

4

Small-scale

0.647

High

1389430

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

Small-scale

0.647

High

1394641

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

20

Small-scale

0.647

High

1462283

CHIP
E3 ubiquitin-protein ligase CHIP

1

14

Small-scale

0.647

High

1490986

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

16

Small-scale

0.647

High

1340074

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

20

High-throughput

0.621

High

1436636

TRI45
E3 ubiquitin-protein ligase TRIM45

1

20

Small-scale

0.621

High

572291

TRI27
Zinc finger protein RFP

2

20

Small-scale

0.613

High

622013

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

1

High-throughput

0.606

High

1049066

REL
Proto-oncogene c-Rel

2

7

High-throughput

0.606

High

1415212

TRI62
E3 ubiquitin-protein ligase TRIM62

2

20

High-throughput

0.606

High

1490993

NEMO
NF-kappa-B essential modulator

2

2

High-throughput

0.606

High

1139163

DAZP2
DAZ-associated protein 2

1

2

High-throughput

0.573

High

1416447

PHF7
E3 ubiquitin-protein ligase PHF7

1

2

High-throughput

0.573

High

1458960

TRI10
Tripartite motif-containing protein 10

1

20

Small-scale

0.555

High

1081519

INCA1
Protein INCA1

1

0

High-throughput

0.549

High

519580

MYBB
Myb-related protein B

1

2

High-throughput

0.541

High

1098868

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

12

High-throughput

0.541

High

1288127

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

20

High-throughput

0.541

High

1294448

DTX1
E3 ubiquitin-protein ligase DTX1

1

20

High-throughput

0.541

High

1307820

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

20

High-throughput

0.541

High

1420388

TRI31
E3 ubiquitin-protein ligase TRIM31

1

20

High-throughput

0.541

High

1453594

BFAR
Bifunctional apoptosis regulator

1

20

High-throughput

0.541

High

1350288

URGCP
Up-regulator of cell proliferation

1

1

High-throughput

0.536

High

1233123

Q6GX22
E3 ubiquitin-protein ligase Midline-1

1

20

High-throughput

0.528

High

1338045

Q8NEX1
E3 ubiquitin-protein ligase ZNRF2

1

20

High-throughput

0.528

High

848953

MAGAB
Melanoma-associated antigen 11

1

0

High-throughput

0.518

High

844117

HD
Huntingtin

1

1

High-throughput

0.515

High

1412799

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.513

High

1180885

UVSSA
UV-stimulated scaffold protein A

1

4

Small-scale

0.501

High

1451196

RN216
E3 ubiquitin-protein ligase RNF216

1

20

Small-scale

0.501

High

1289221

CAPS2
Calcium-dependent secretion activator 2

1

6

High-throughput

0.494

High

1384952

TRI43
Tripartite motif-containing protein 43

1

20

High-throughput

0.494

High

1116984

CD166
CD166 antigen

1

3

High-throughput

0.489

High

142704

TRI38
E3 ubiquitin-protein ligase TRIM38

1

20

Small-scale

0.481

High

964557

UFM1
Ubiquitin-fold modifier 1

1

5

High-throughput

0.481

High

888408

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

984340

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.470

High

320169

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.457

High

1293437

CARM1
Histone-arginine methyltransferase CARM1

1

1

High-throughput

0.457

High

1490992

SNURF
SNRPN upstream reading frame protein

1

3

High-throughput

0.457

High

1454507

ZNFX1
NFX1-type zinc finger-containing protein 1

1

2

High-throughput

0.417

High

317264

AL1A2
Retinal dehydrogenase 2

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025