HitPredict

Interactor 1: HNRPL (P14866)
Heterogeneous nuclear ribonucleoprotein L (hnRNP L)
Gene: HNRNPL

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	30517763, 16055720
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 589 Hs			1 903
+	Hs
		131709 HNRPL_HUMAN (1-589): 6.82e-112: 348: 100.00		WWP2_HUMAN (1-903): 0: 808: 54.18
+	Hs
		550415 PABP1_HUMAN (53-384): 4.56e-42: 162: 16.19		ITCH_HUMAN (1-903): 0: 913: 100.00
+	Hs
		846470 MATR3_HUMAN (71-364): 1.68e-59: 214: 20.64		WWP1_HUMAN (1-903): 0: 837: 57.00
+	Hs
		131798 MATR3_HUMAN (71-364): 1.68e-59: 214: 20.64		WWP2_HUMAN (1-903): 0: 808: 54.18
+	Hs
		576313 HNRPL_HUMAN (1-589): 6.82e-112: 348: 100.00		NEDD4_HUMAN (90-900): 0: 670: 34.16
+	Hs
		131699 PABP1_HUMAN (53-384): 4.56e-42: 162: 16.19		WWP2_HUMAN (1-903): 0: 808: 54.18
+	Hs
		132010 PABP4_HUMAN (53-389): 1.51e-41: 161: 13.71		WWP2_HUMAN (1-903): 0: 808: 54.18
+	Hs
		131744 PTBP1_HUMAN (59-445): 1.78e-10: 65.8: 12.35		WWP2_HUMAN (1-903): 0: 808: 54.18