HitPredict

Interactor 1: PTPRA (P18433)
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)
Gene: PTPRA

Interactor 2: PTPRE (P23469)
Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)
Gene: PTPRE

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.943

Property	Details
Experiments	27880917, 28514442, 27432908, 32062451, 33961781, 28330616
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Y_phosphatase~Y_phosphatase
Common GO terms	GO:0004725 - protein tyrosine phosphatase activity GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 802 Hs			1 700
+	Hs
		576980 PTPRA_HUMAN (1-802): 0: 1040: 100.00		PTPRA_HUMAN (13-700): 0: 863: 66.52
+	Mm
		69645 PTPRA_MOUSE (1-802): 0: 1003: 90.69		PTPRS_MOUSE (1-697): 0: 890: 40.99
+	Mm
		574008 PTPRA_MOUSE (1-802): 0: 1003: 90.69		PTPRD_MOUSE (1-697): 0: 885: 41.54
+	Mm
		56906 PTPRA_MOUSE (1-802): 0: 1003: 90.69		PTPRF_MOUSE (3-697): 0: 869: 42.35
+	Mm
		574002 PTPRA_MOUSE (1-802): 0: 1003: 90.69		PTPRE_MOUSE (1-700): 0: 860: 92.73
+	Mm
		573997 PTPRA_MOUSE (1-802): 0: 1003: 90.69		PTPRA_MOUSE (26-700): 0: 842: 64.10
+	Hs
		1031977 PTPRS_HUMAN (5-799): 0: 925: 38.45		PTPRS_HUMAN (1-697): 0: 886: 40.50
+	Hs
		616971 PTPRS_HUMAN (5-799): 0: 925: 38.45		PTPRD_HUMAN (1-697): 0: 883: 41.54
+	Mm
		69646 PTPRS_MOUSE (5-799): 0: 930: 38.96		PTPRE_MOUSE (1-700): 0: 860: 92.73
+	Hs
		489957 PTPRS_HUMAN (5-799): 0: 925: 38.45		PTPRF_HUMAN (3-697): 0: 864: 42.21
+	Hs
		576984 PTPRA_HUMAN (1-802): 0: 1040: 100.00		PTPRG_HUMAN (11-695): 0: 745: 32.78
+	Mm
		828098 PTPRD_MOUSE (38-799): 0: 900: 40.63		PTPRE_MOUSE (1-700): 0: 860: 92.73
+	Hs
		577029 PTPRA_HUMAN (1-802): 0: 1040: 100.00		Q5VWH6_HUMAN (1-140): 6.13e-94: 288: 100.00
+	Hs
		616916 PTPRS_HUMAN (5-799): 0: 925: 38.45		PTPRB_HUMAN (336-692): 2.25e-108: 363: 30.66
+	Mm
		574010 PTPRA_MOUSE (1-802): 0: 1003: 90.69		S4R1M0_MOUSE (120-423): 3.1e-71: 253: 28.61
+	Mm
		573998 PTPRA_MOUSE (1-802): 0: 1003: 90.69		PTPRM_MOUSE (115-398): 5.32e-65: 236: 33.22
+	Mm
		69654 PTPRS_MOUSE (5-799): 0: 930: 38.96		S4R1M0_MOUSE (120-423): 3.1e-71: 253: 28.61