Interactor 1: BRAF (P15056)
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)
Gene: BRAF
Interactor 2: PLCG2 (P16885)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)
Gene: PLCG2
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.42 | 1.00 | 0.653 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 35512704 |
| Identification Methods | split luciferase complementation, pull down |
| Interaction Type | physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | C1_1~C2, C1_1~SH2, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1 |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010628 - positive regulation of gene expression GO:0050852 - T cell receptor signaling pathway and 2 others more... |
| Homologous interactions | 6 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
