HitPredict

Interactor 1: CADH2 (P19022)
Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)
Gene: CDH2

Interactor 2: PTN7 (P35236)
Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP)
Gene: PTPN7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0019901 - protein kinase binding GO:0030054 - cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 360
+	Hs
		580234 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRR_HUMAN (6-358): 8.71e-139: 410: 53.52
+	Hs
		580200 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRB_HUMAN (14-358): 2.81e-121: 387: 31.64
+	Hs
		580229 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRJ_HUMAN (82-355): 1.17e-116: 369: 35.71
+	Hs
		580238 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRO_HUMAN (85-356): 2.5e-115: 363: 37.14
+	Hs
		580204 CADH2_HUMAN (1-906): 0: 998: 100.00		PTN6_HUMAN (80-356): 8.75e-116: 350: 34.46
+	Rn
		1145482 CADH2_RAT (1-906): 0: 989: 96.25		PTPRF_RAT (93-354): 1.33e-102: 333: 34.57
+	Hs
		576981 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRA_HUMAN (93-355): 1.23e-102: 321: 36.30
+	Hs
		441173 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRC_HUMAN (69-353): 6.02e-83: 276: 30.72
+	Hs
		580235 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRK_HUMAN (86-353): 5.73e-61: 213: 26.07
+	Rn
		94056 CADH2_RAT (1-906): 0: 989: 96.25		F1LPJ1_RAT (73-353): 1.5e-63: 221: 26.53
+	Hs
		580201 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRG_HUMAN (71-360): 5.74e-56: 199: 23.76
+	Hs
		521898 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRJ_HUMAN (82-355): 1.17e-116: 369: 35.71
+	Hs
		521727 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRD_HUMAN (93-354): 1.28e-105: 342: 36.06
+	Hs
		521907 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRS_HUMAN (78-354): 2.75e-105: 341: 34.03
+	Hs
		489891 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRF_HUMAN (93-354): 6.22e-102: 331: 34.57
+	Hs
		616974 DSC3_HUMAN (5-899): 0: 700: 30.32		PTPRD_HUMAN (93-354): 1.28e-105: 342: 36.06
+	Hs
		521743 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRM_HUMAN (73-353): 3.63e-63: 219: 26.53
+	Mm
		454946 CADH1_MOUSE (2-906): 0: 743: 45.13		PTPRM_MOUSE (73-353): 1.47e-63: 221: 26.53
+	Hs
		521728 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRG_HUMAN (71-360): 5.74e-56: 199: 23.76
+	Hs
		1031982 DSG2_HUMAN (153-725): 6.3e-92: 316: 34.54		PTPRS_HUMAN (78-354): 2.75e-105: 341: 34.03