HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: KEAP1 (Q14145)
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19)
Gene: KEAP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	26517842
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0071353 - cellular response to interleukin-4 GO:0097718 - disordered domain specific binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 624
+	Hs
		461466 HS90A_HUMAN (1-724): 0: 1069: 85.25		KEAP1_HUMAN (1-624): 0: 582: 100.00
+	Hs
		468450 HS90B_HUMAN (1-724): 0: 1083: 100.00		KLH26_HUMAN (43-612): 2.19e-143: 431: 26.58
+	Hs
		468449 HS90B_HUMAN (1-724): 0: 1083: 100.00		KLH22_HUMAN (38-612): 1.34e-141: 427: 25.04
+	Hs
		468653 HS90B_HUMAN (1-724): 0: 1083: 100.00		KLHL6_HUMAN (7-611): 9.12e-142: 427: 22.35
+	Hs
		461558 HS90A_HUMAN (1-724): 0: 1069: 85.25		KLH26_HUMAN (43-612): 2.19e-143: 431: 26.58
+	Hs
		461557 HS90A_HUMAN (1-724): 0: 1069: 85.25		KLH22_HUMAN (38-612): 1.34e-141: 427: 25.04
+	Hs
		461767 HS90A_HUMAN (1-724): 0: 1069: 85.25		KLHL6_HUMAN (7-611): 9.12e-142: 427: 22.35
+	Hs
		468870 HS90B_HUMAN (1-724): 0: 1083: 100.00		KLH13_HUMAN (424-619): 5.72e-46: 174: 30.05
+	Hs
		468591 HS90B_HUMAN (1-724): 0: 1083: 100.00		KLH36_HUMAN (407-621): 1.94e-41: 161: 22.67
+	Hs
		468836 HS90B_HUMAN (1-724): 0: 1083: 100.00		KLHL1_HUMAN (470-624): 2.2e-39: 156: 37.82
+	Hs
		461702 HS90A_HUMAN (1-724): 0: 1069: 85.25		KLH36_HUMAN (407-621): 1.94e-41: 161: 22.67
+	Hs
		468495 HS90B_HUMAN (1-724): 0: 1083: 100.00		KLH10_HUMAN (452-621): 2.13e-36: 146: 29.83
+	Hs
		461593 HS90A_HUMAN (1-724): 0: 1069: 85.25		KLH10_HUMAN (452-621): 2.13e-36: 146: 29.83
+	Hs
		468681 HS90B_HUMAN (1-724): 0: 1083: 100.00		KLH29_HUMAN (451-622): 1.05e-28: 124: 24.29
+	Hs
		468600 HS90B_HUMAN (1-724): 0: 1083: 100.00		KLH23_HUMAN (453-620): 5e-29: 123: 25.15
+	Hs
		461798 HS90A_HUMAN (1-724): 0: 1069: 85.25		KLH29_HUMAN (451-622): 1.05e-28: 124: 24.29
+	Hs
		461712 HS90A_HUMAN (1-724): 0: 1069: 85.25		KLH23_HUMAN (453-620): 5e-29: 123: 25.15
+	Hs
		161280 HS90B_HUMAN (1-724): 0: 1083: 100.00		ENC1_HUMAN (516-620): 6.55e-15: 79.9: 17.93
+	Hs
		468787 HS90B_HUMAN (1-724): 0: 1083: 100.00		KLH25_HUMAN (516-623): 9.62e-15: 79.5: 19.27
+	Hs
		161279 HS90A_HUMAN (1-724): 0: 1069: 85.25		ENC1_HUMAN (516-620): 6.55e-15: 79.9: 17.93