HitPredict

Interactor 1: ML12A (P19105)
Myosin regulatory light chain 12A (Epididymis secretory protein Li 24) (HEL-S-24) (MLC-2B) (Myosin RLC) (Myosin regulatory light chain 2, nonsarcomeric) (Myosin regulatory light chain MRLC3)
Gene: MYL12A

Interactor 2: MYH9 (P35579)
Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)
Gene: MYH9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	35271311, 26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EF-hand_7~Myosin_head, EF-hand_7~Myosin_N
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome GO:0070527 - platelet aggregation
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 171 Hs			1 1960
+	Ce
		104561 CALM_CAEEL (16-92): 2.97e-09: 54.5: 27.16		G5EBY3_CAEEL (19-1920): 0: 1295: 44.84
+	Hs
		159549 ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37		MYH9_HUMAN (1-1923): 0: 1124: 100.00
+	Hs
		624341 MYL9_HUMAN (14-171): 2.29e-64: 196: 94.30		MYH9_HUMAN (1-1923): 0: 1124: 100.00
+	Hs
		648467 CALL3_HUMAN (31-92): 1.25e-10: 58.2: 27.27		MYH9_HUMAN (1-1923): 0: 1124: 100.00
+	Mm
		1143166 Q6ZWQ9_MOUSE (1-171): 4.56e-64: 196: 97.09		MYH10_MOUSE (943-1959): 8.39e-63: 240: 17.33
+	Hs
		580616 ML12A_HUMAN (1-171): 2.06e-65: 199: 100.00		MYH11_HUMAN (723-1800): 1.94e-59: 229: 16.27
+	Hs
		159551 ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37		MYH11_HUMAN (723-1800): 1.94e-59: 229: 16.27
+	Dm
		773034 SQH_DROME (1-171): 2.38e-60: 186: 80.46		MYSN_DROME (938-1959): 1.1e-59: 230: 16.51
+	Hs
		501101 MLRV_HUMAN (9-165): 2.99e-55: 173: 58.23		MYH1_HUMAN (1063-1960): 1.36e-56: 220: 15.08
+	Dm
		404219 MLR_DROME (8-162): 4.11e-30: 110: 41.14		MYSA_DROME (939-1960): 2.45e-65: 248: 17.74
+	Ce
		361111 MLR1_CAEEL (23-169): 2.25e-39: 133: 49.32		MYO4_CAEEL (730-1729): 1.73e-53: 209: 16.65
+	Ce
		361112 MLR2_CAEEL (23-169): 1.93e-39: 133: 49.32		MYO4_CAEEL (730-1729): 1.73e-53: 209: 16.65
+	Hs
		580665 ML12A_HUMAN (1-171): 2.06e-65: 199: 100.00		MYH14_HUMAN (1316-1960): 4.14e-32: 139: 15.50
+	Hs
		159595 ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37		MYH14_HUMAN (1316-1960): 4.14e-32: 139: 15.50
+	Ce
		361122 MLR1_CAEEL (23-169): 2.25e-39: 133: 49.32		MYO1_CAEEL (1258-1960): 1.1e-43: 177: 15.63
+	Ce
		361123 MLR2_CAEEL (23-169): 1.93e-39: 133: 49.32		MYO1_CAEEL (1258-1960): 1.1e-43: 177: 15.63
+	Hs
		580615 ML12A_HUMAN (1-171): 2.06e-65: 199: 100.00		MYH10_HUMAN (1676-1957): 4.42e-10: 67.4: 16.84
+	Hs
		159550 ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37		MYH10_HUMAN (1676-1957): 4.42e-10: 67.4: 16.84
+	Hs
		624342 MYL9_HUMAN (14-171): 2.29e-64: 196: 94.30		MYH10_HUMAN (1676-1957): 4.42e-10: 67.4: 16.84