HitPredict

Interactor 1: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1290 Hs			1 1342
+	Hs
		562623 PLCG2_HUMAN (18-1287): 0: 1128: 49.45		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		581010 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		383601 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337912 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		562648 PLCG2_HUMAN (18-1287): 0: 1128: 49.45		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		383591 PLCG2_HUMAN (18-1287): 0: 1128: 49.45		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337886 PLCG2_HUMAN (18-1287): 0: 1128: 49.45		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337341 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		434135 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		580937 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Hs
		580965 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		580953 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Hs
		562635 PLCG2_HUMAN (18-1287): 0: 1128: 49.45		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		580983 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FAK1_HUMAN (713-992): 4.43e-41: 167: 32.19
+	Hs
		411292 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		INSR_HUMAN (329-650): 2.27e-22: 106: 16.98
+	Rn
		499158 PLCG1_RAT (1-1290): 0: 1299: 96.90		INSR_RAT (329-650): 1.42e-20: 101: 16.71
+	Hs
		338511 PLCH1_HUMAN (847-1284): 8.88e-86: 310: 27.09		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Mm
		1141452 PLCG2_MOUSE (19-1287): 0: 1131: 50.12		MERTK_MOUSE (659-1033): 2.5e-41: 167: 32.08
+	Mm
		337619 PTN11_MOUSE (546-769): 4.4e-68: 243: 26.86		ABL1_MOUSE (696-1296): 5.65e-125: 417: 22.21
+	Hs
		537758 PLCD3_HUMAN (735-1214): 3.7e-87: 303: 27.27		INSRR_HUMAN (329-644): 4.31e-16: 86.4: 14.51