Protein: PTSS1
Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I)

Gene: PTSS1, PTDSS1
Organism: Homo sapiens
Interactions: 216
UniProt ID: P48651

Gene Ontology (top 5):
GO:0005789 - endoplasmic reticulum membrane
GO:0006659 - phosphatidylserine biosynthetic process
GO:0016020 - membrane
GO:0016740 - transferase activity
GO:0106245 - L-serine-phosphatidylethanolamine phosphatidyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

395679

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

230281

CREB3
Cyclic AMP-responsive element-binding protein 3

2

0

High-throughput

0.565

High

876302

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

711064

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

0

High-throughput

0.547

High

248683

PEPL
Periplakin

1

3

High-throughput

0.536

High

483890

HMOX1
Heme oxygenase 1

1

1

High-throughput

0.536

High

609622

LEG3
Galectin-3

1

1

High-throughput

0.536

High

652291

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.536

High

690200

STOM
Stomatin

1

2

High-throughput

0.536

High

876301

EPIPL
Epiplakin

1

4

High-throughput

0.536

High

876329

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

1

1

High-throughput

0.536

High

876347

MBOA5
Lysophospholipid acyltransferase 5

1

1

High-throughput

0.536

High

876365

RDHE2
Epidermal retinol dehydrogenase 2

1

1

High-throughput

0.536

High

876375

EVPL
Envoplakin

1

4

High-throughput

0.536

High

186162

LX15B
Polyunsaturated fatty acid lipoxygenase ALOX15B

1

0

High-throughput

0.513

High

410708

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

0

High-throughput

0.513

High

869562

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

High-throughput

0.513

High

870477

PPCE
Prolyl endopeptidase

1

0

High-throughput

0.513

High

876321

ASAH1
Acid ceramidase

1

0

High-throughput

0.513

High

876341

ATG9B
Autophagy-related protein 9B

1

0

High-throughput

0.513

High

876345

SAPL1
Proactivator polypeptide-like 1 [Cleaved into: Saposin A-like; Saposin B-Val-like; Saposin B-like; Saposin C-like; Saposin D-like]

1

0

High-throughput

0.513

High

876354

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.513

High

876355

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

0

High-throughput

0.513

High

876377

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.513

High

876386

GSDMA
Gasdermin-A

1

0

High-throughput

0.513

High

876396

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

876415

NEUR2
Sialidase-2

1

0

High-throughput

0.513

High

596966

TSHR
Thyrotropin receptor

1

3

High-throughput

0.494

High

85964

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

4

High-throughput

0.489

High

136063

PLK4
Serine/threonine-protein kinase PLK4

1

1

High-throughput

0.489

High

210727

KLK10
Kallikrein-10

1

1

High-throughput

0.489

High

261610

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

277599

H2AY
Core histone macro-H2A.1

1

2

High-throughput

0.489

High

358877

AL1A1
Aldehyde dehydrogenase 1A1

1

1

High-throughput

0.489

High

402879

ANXA1
Annexin A1

1

1

High-throughput

0.489

High

423753

APOD
Apolipoprotein D

1

1

High-throughput

0.489

High

424161

S10A8
Protein S100-A8

1

6

High-throughput

0.489

High

460785

CATB
Cathepsin B

1

2

High-throughput

0.489

High

485784

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

High-throughput

0.489

High

568128

PLSL
Plastin-2

1

1

High-throughput

0.489

High

568950

ANXA8
Annexin A8

1

1

High-throughput

0.489

High

587589

DESP
Desmoplakin

1

4

High-throughput

0.489

High

635572

FILA
Filaggrin

1

4

High-throughput

0.489

High

640373

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

8

High-throughput

0.489

High

682468

S100P
Protein S100-P

1

8

High-throughput

0.489

High

713344

SPB3
Serpin B3

1

2

High-throughput

0.489

High

724545

S10A7
Protein S100-A7

1

8

High-throughput

0.489

High

754561

S10A3
Protein S100-A3

1

8

High-throughput

0.489

High

787621

SPB5
Serpin B5

1

2

High-throughput

0.489

High

868071

AL1A3
Retinaldehyde dehydrogenase 3

1

1

High-throughput

0.489

High

868660

LEG7
Galectin-7

1

1

High-throughput

0.489

High

874760

SPB4
Serpin B4

1

2

High-throughput

0.489

High

876296

KLK7
Kallikrein-7

1

1

High-throughput

0.489

High

876311

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.489

High

876314

NGAL
Neutrophil gelatinase-associated lipocalin

1

1

High-throughput

0.489

High

876320

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

1

High-throughput

0.489

High

876323

PKP1
Plakophilin-1

1

2

High-throughput

0.489

High

876330

PLEC
Plectin

1

2

High-throughput

0.489

High

876337

FILA2
Filaggrin-2

1

4

High-throughput

0.489

High

876351

CAN12
Calpain-12

1

1

High-throughput

0.489

High

876357

S1A7A
Protein S100-A7A

1

8

High-throughput

0.489

High

876369

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

1

High-throughput

0.489

High

876372

LRC15
Leucine-rich repeat-containing protein 15

1

1

High-throughput

0.489

High

876380

S10AG
Protein S100-A16

1

8

High-throughput

0.489

High

876384

CPNS2
Calpain small subunit 2

1

3

High-throughput

0.489

High

876387

SRPK1
SRSF protein kinase 1

1

1

High-throughput

0.489

High

876398

S10AE
Protein S100-A14

1

8

High-throughput

0.489

High

876405

CALL5
Calmodulin-like protein 5

1

1

High-throughput

0.489

High

876416

PKP3
Plakophilin-3

1

2

High-throughput

0.489

High

876318

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

0

High-throughput

0.479

High

466149

RHOC
Rho-related GTP-binding protein RhoC

1

5

High-throughput

0.479

High

540355

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

561943

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

580925

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

766306

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

876300

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

876304

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.479

High

876305

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

876309

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.479

High

876315

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

876336

TM41B
Transmembrane protein 41B

1

1

High-throughput

0.479

High

876342

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.479

High

876383

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.479

High

876394

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.479

High

241049

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

315267

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

319516

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

325724

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.458

High

342789

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

345513

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

417312

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

418005

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

847464

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

876308

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

876319

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

876328

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

876334

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

876378

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

876382

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

876388

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

876401

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

876402

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

876404

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

876406

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

876408

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.458

High

876344

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

876368

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.445

High

876370

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

1

High-throughput

0.445

High

126502

RHOD
Rho-related GTP-binding protein RhoD

1

8

High-throughput

0.437

High

217952

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

715478

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.437

High

830327

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

876299

RND2
Rho-related GTP-binding protein RhoN

1

7

High-throughput

0.437

High

876331

RHOH
Rho-related GTP-binding protein RhoH

1

6

High-throughput

0.437

High

876333

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.437

High

876346

TECT3
Tectonic-3

1

2

High-throughput

0.437

High

876352

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

876356

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

876367

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.437

High

876374

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

876381

TECT2
Tectonic-2

1

2

High-throughput

0.437

High

876395

RHOJ
Rho-related GTP-binding protein RhoJ

1

6

High-throughput

0.437

High

876397

RHOF
Rho-related GTP-binding protein RhoF

1

7

High-throughput

0.437

High

876414

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.437

High

516653

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.426

High

876392

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.426

High

91849

C9JUP7
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.407

High

379081

IGKC
Immunoglobulin kappa constant

1

4

High-throughput

0.407

High

379229

IGHG1
Immunoglobulin heavy constant gamma 1

1

4

High-throughput

0.407

High

379342

IGHG2
Immunoglobulin heavy constant gamma 2

1

4

High-throughput

0.407

High

506522

IGLC6
Immunoglobulin lambda constant 6

1

4

High-throughput

0.407

High

876339

S35F1
Solute carrier family 35 member F1

1

1

High-throughput

0.407

High

161864

IMPA2
Inositol monophosphatase 2

1

0

High-throughput

0.279

Low

289215

CREG1
Protein CREG1

1

0

High-throughput

0.279

Low

326681

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.279

Low

338233

G6PE
GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase

1

0

High-throughput

0.279

Low

353097

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.279

Low

369844

CO3
Complement C3

1

0

High-throughput

0.279

Low

384642

CRYAB
Alpha-crystallin B chain

1

0

High-throughput

0.279

Low

389652

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.279

Low

389983

ALBU
Albumin

1

0

High-throughput

0.279

Low

390873

TRFE
Serotransferrin

1

0

High-throughput

0.279

Low

391131

HEMO
Hemopexin

1

0

High-throughput

0.279

Low

423618

ARGI1
Arginase-1

1

0

High-throughput

0.279

Low

442264

GELS
Gelsolin

1

0

High-throughput

0.279

Low

457848

INVO
Involucrin

1

0

High-throughput

0.279

Low

540999

PIM1
Serine/threonine-protein kinase pim-1

1

0

High-throughput

0.279

Low

577666

PLAK
Junction plakoglobin

1

0

High-throughput

0.279

Low

582558

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.279

Low

595349

H15
Histone H1.5

1

0

High-throughput

0.279

Low

609298

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.279

Low

615208

IL1RA
Interleukin-1 receptor antagonist protein

1

0

High-throughput

0.279

Low

627116

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.279

Low

692670

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

700441

PSB8
Proteasome subunit beta type-8

1

0

High-throughput

0.279

Low

729524

CASPE
Caspase-14

1

0

High-throughput

0.279

Low

846003

CACP
Carnitine O-acetyltransferase

1

0

High-throughput

0.279

Low

876295

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

876297

PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

1

0

High-throughput

0.279

Low

876306

NPC2
NPC intracellular cholesterol transporter 2

1

0

High-throughput

0.279

Low

876312

NTH
Endonuclease III-like protein 1

1

0

High-throughput

0.279

Low

876313

PHLD
Phosphatidylinositol-glycan-specific phospholipase D

1

0

High-throughput

0.279

Low

876316

DIAC
Di-N-acetylchitobiase

1

0

High-throughput

0.279

Low

876322

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.279

Low

876324

TRI29
Tripartite motif-containing protein 29

1

0

High-throughput

0.279

Low

876332

CYTM
Cystatin-M

1

0

High-throughput

0.279

Low

876335

PA24E
Cytosolic phospholipase A2 epsilon

1

0

High-throughput

0.279

Low

876338

CAHM4
Calcium homeostasis modulator protein 4

1

0

High-throughput

0.279

Low

876343

HPHL1
Ferroxidase HEPHL1

1

0

High-throughput

0.279

Low

876348

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

876353

FBX50
F-box only protein 50

1

0

High-throughput

0.279

Low

876358

LYG2
Lysozyme g-like protein 2

1

0

High-throughput

0.279

Low

876359

DSG4
Desmoglein-4

1

0

High-throughput

0.279

Low

876362

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

876373

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

876376

DNSL2
Deoxyribonuclease-1-like 2

1

0

High-throughput

0.279

Low

876393

RNAS7
Ribonuclease 7

1

0

High-throughput

0.279

Low

876400

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.279

Low

876409

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.279

Low

876410

DPP2
Dipeptidyl peptidase 2

1

0

High-throughput

0.279

Low

876411

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.279

Low

876412

CLC4K
C-type lectin domain family 4 member K

1

0

High-throughput

0.279

Low

876413

PADI3
Protein-arginine deiminase type-3

1

0

High-throughput

0.279

Low

876417

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

0

High-throughput

0.279

Low

876418

FCGBP
IgGFc-binding protein

1

0

High-throughput

0.279

Low

876303

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.261

Low

47961

RBM47
RNA-binding protein 47

1

0

High-throughput

0.249

Low

128853

MEN1
Menin

1

0

High-throughput

0.249

Low

588169

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

694892

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

767666

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

876294

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

876298

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

876307

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

876310

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

876317

TF65
Transcription factor p65

1

0

High-throughput

0.249

Low

876325

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

876327

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.249

Low

876350

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

876361

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

876364

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

876366

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

876371

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

876379

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

876385

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

876389

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.249

Low

876390

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.249

Low

876391

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.249

Low

876399

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.249

Low

876403

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.249

Low

876407

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

876326

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.232

Low

876340

H37
Histone H3-7

1

0

High-throughput

0.232

Low

876349

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

0

High-throughput

0.232

Low

876360

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.232

Low

876363

S15A3
Solute carrier family 15 member 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025