HitPredict

Interactor 1: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Interactor 2: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	35384245, 36736316
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1290 Hs			1 806
+	Hs
		580937 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		EPHB2_HUMAN (1-788): 0: 624: 19.15
+	Hs
		580965 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		EPHA4_HUMAN (1-781): 0: 622: 20.78
+	Hs
		499230 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		KIT_HUMAN (19-794): 1.17e-165: 506: 24.62
+	Hs
		581012 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		NTRK3_HUMAN (130-757): 4.66e-167: 506: 24.59
+	Hs
		581014 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		NTRK2_HUMAN (159-756): 1.53e-161: 491: 25.51
+	Mm
		546302 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		NTRK2_MOUSE (158-756): 2.71e-161: 490: 25.19
+	Rn
		499163 PLCG1_RAT (1-1290): 0: 1299: 96.90		NTRK2_RAT (135-756): 1.07e-160: 489: 24.74
+	Hs
		384239 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02
+	Mm
		1112476 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		NTRK1_MOUSE (158-763): 7.67e-148: 455: 26.76
+	Hs
		434135 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		RET_HUMAN (453-801): 9.71e-98: 330: 48.63
+	Mm
		452188 PLCG2_MOUSE (19-1287): 0: 1131: 50.12		CSF1R_MOUSE (5-764): 1.87e-167: 511: 27.49
+	Hs
		499228 PLCG2_HUMAN (18-1287): 0: 1128: 49.45		KIT_HUMAN (19-794): 1.17e-165: 506: 24.62
+	Mm
		729715 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		VGFR1_MOUSE (7-475): 3.77e-32: 136: 15.94
+	Mm
		729415 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		VGFR2_MOUSE (7-382): 1.24e-31: 135: 16.10
+	Hs
		580949 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		VGFR2_HUMAN (5-342): 3.81e-17: 88.6: 16.58
+	Hs
		507843 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Hs
		572583 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		VGFR1_HUMAN (40-357): 6.77e-13: 74.8: 13.25
+	Hs
		580923 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56
+	Hs
		580926 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FGFR4_HUMAN (1-130): 1.18e-11: 70.5: 19.31
+	Rn
		499160 PLCG1_RAT (1-1290): 0: 1299: 96.90		FGFR1_RAT (1-114): 1.76e-14: 79.7: 18.32